Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Shao, L.; Moloney, D.J.; Haltiwanger, R.
    Fringe modifies O-fucose on mouse Notch1 at epidermal growth factor-like repeats within the ligand-binding site and the Abruptex region (2003), J. Biol. Chem., 278, 7775-7782.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.222 Notch + UDP-D-GlcNAc Drosophila melanogaster enzyme plays a key role in the specification of boundaries during development by modulating the ability of Notch ligands to activate Notch receptors beta-D-glucosaminyl-Notch + UDP
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.222 Drosophila melanogaster
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.4.1.222 UDP-beta-D-GlcNAc + PCQNGGS(O-beta-L-fucosyl)-CKDQL = UDP + PCQNGGS(O-D-GlcNAcbeta(1-3)-L-Fucbeta)-CKDQL mechanism Drosophila melanogaster
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.222 factor VII EGF repeat + UDP-D-GlcNAc Manic fringe modifies O-fucose on mouse Notch1 at extracellular epidermal growth factor-like repeats within the ligand-binding site and the Abruptex region expressed in Lec1 cells Drosophila melanogaster beta-D-glucosaminyl-factor VII EGF repeat + UDP
-
 ?
2.4.1.222 additional information activity on different factor VII EGF repeat containing protein fragments, overview Drosophila melanogaster ?
-
 ?
2.4.1.222 Notch + UDP-D-GlcNAc enzyme plays a key role in the specification of boundaries during development by modulating the ability of Notch ligands to activate Notch receptors Drosophila melanogaster beta-D-glucosaminyl-Notch + UDP
-
 ?
2.4.1.222 Notch1 + UDP-D-GlcNAc Manic fringe modifies O-fucose on mouse Notch1 at extracellular epidermal growth factor-like repeats within the ligand-binding site and the Abruptex region expressed in Lec1 cells Drosophila melanogaster beta-D-glucosaminyl-Notch1 + UDP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.222 beta1,3-N-acetylglusoaminyltransferase
-
 Drosophila melanogaster
2.4.1.222 Fringe protein
-
 Drosophila melanogaster
2.4.1.222 Manic fringe
-
 Drosophila melanogaster