EC Number | Crystallization (Comment) | Organism |
---|---|---|
2.4.1.37 | crystals of purified native enzyme are soaked with various combinations of UDP-GalNAc, UDP-Gal, UDP, and acceptor analogues alpha-L-fucosyl-1,2-beta-D-(3-deoxy)-galactosyl-O-R or alpha-L-fucosyl-1,2-beta-D-(3-amino)-galactosyl-O-R, ligands are solved in 7.5% PEG 4000, 15% glycerol, 75 mM N-[2-acetamido]-2-iminodiacetic acid, pH 7.5, 10 mM MnCl2, and 10 mM inhibitor, 3-4 days, X-ray diffraction structure determination and analysis at 1.6 A resolution | Homo sapiens |
2.4.1.40 | crystals of purified native enzyme are soaked with various combinations of UDP-GalNAc, UDP-Gal, UDP, and acceptor analogues alpha-L-fucosyl-1-2-beta-D-(3-deoxy)-galactosyl-O-R or alpha-L-fucosyl-1-2-beta-D-(3-amino)-galactosyl-O-R, ligands are solved in 7.5% PEG 4000, 15% glycerol, 75 mM N-[2-acetamido]-2-iminodiacetic acid, pH 7.5, 10 mM MnCl2, and 10 mM inhibitor, 3-4 days, X-ray diffraction structure determination and analysis at 2.1 A resolution | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.4.1.37 | alpha-L-fucosyl-(1-2)-beta-D-(3-amino)-galactosyl-O-R | complex mode inhibitor, binding structure, Met226 is involved by interacting with the C3-position group | Homo sapiens | |
2.4.1.37 | alpha-L-fucosyl-(1-2)-beta-D-(3-deoxy)-galactosyl-O-R | competitive inhibitor, binding structure, Met226 is involved by interacting with the C3-position group | Homo sapiens | |
2.4.1.40 | alpha-L-fucosyl-1-2-beta-D-(3-amino)-galactosyl-O-R | complex mode inhibitor, binding structure, Leu226 is involved by interacting with the C3-position group | Homo sapiens | |
2.4.1.40 | alpha-L-fucosyl-1-2-beta-D-(3-deoxy)-galactosyl-O-R | competitive inhibitor, binding structure, Leu226 is involved by interacting with the C3-position group | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.37 | UDP-galactose + alpha-L-fucosyl-(1-2)-D-galactosyl-O-R | Homo sapiens | H-antigen disaccharide | UDP + alpha-D-galactosyl-(1-3)-[alpha-L-fucosyl-(1-2)]-D-galactosyl-O-R | - |
? | |
2.4.1.40 | UDP-N-acetyl-D-galactosamine + alpha-L-fucosyl-1-2-D-galactosyl-O-R | Homo sapiens | H-antigen disaccharide | UDP + N-acetyl-alpha-D-galactosaminyl-1,3-[alpha-L-fucosyl-1-2]-D-galactosyl-O-R | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.1.37 | Homo sapiens | P16442 | - |
- |
2.4.1.40 | Homo sapiens | P16442 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.37 | UDP-galactose + alpha-L-fucosyl-(1-2)-D-galactosyl-O-R | H-antigen disaccharide | Homo sapiens | UDP + alpha-D-galactosyl-(1-3)-[alpha-L-fucosyl-(1-2)]-D-galactosyl-O-R | - |
? | |
2.4.1.37 | UDP-galactose + alpha-L-fucosyl-(1-2)-D-galactosyl-O-R | H-antigen disaccharide, Met226 is responsible for substrate specificity for D-galactose as donor substrate, acceptor substrate binding pocket structure, overview | Homo sapiens | UDP + alpha-D-galactosyl-(1-3)-[alpha-L-fucosyl-(1-2)]-D-galactosyl-O-R | - |
? | |
2.4.1.40 | UDP-N-acetyl-D-galactosamine + alpha-L-fucosyl-1-2-D-galactosyl-O-R | H-antigen disaccharide | Homo sapiens | UDP + N-acetyl-alpha-D-galactosaminyl-1,3-[alpha-L-fucosyl-1-2]-D-galactosyl-O-R | - |
? | |
2.4.1.40 | UDP-N-acetyl-D-galactosamine + alpha-L-fucosyl-1-2-D-galactosyl-O-R | H-antigen disaccharide, Leu226 is responsible for substrate specificity for UDP-N-acetyl-D-galactosamine as donor substrate, acceptor substrate binding pocket structure, overview | Homo sapiens | UDP + N-acetyl-alpha-D-galactosaminyl-1,3-[alpha-L-fucosyl-1-2]-D-galactosyl-O-R | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.4.1.37 | ABO(H) blood group B glycosyltransferase | - |
Homo sapiens |
2.4.1.37 | GTB | - |
Homo sapiens |
2.4.1.40 | ABO(H) blood group A glycosyltransferase | - |
Homo sapiens |
2.4.1.40 | GTA | - |
Homo sapiens |