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Literature summary extracted from

  • Kukkola, L.; Hieta, R.; Kivirikko, K.I.; Myllyharju, J.
    Identification and characterization of a third human, rat, and mouse collagen prolyl 4-hydroxylase isoenzyme (2003), J. Biol. Chem., 278, 47685-47693.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.11.2 ascorbate required for activity Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.11.2
-
 Rattus norvegicus
1.14.11.2
-
 Mus musculus
1.14.11.2 expression in insect cells and HEK-293 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.11.2 poly(L-Pro) 0.03 mM, 50% inhibition Homo sapiens
1.14.11.2 Pyridine-2,4-dicarboxylate 0.011 mM, 50% inhibition Homo sapiens
1.14.11.2 Pyridine-2,5-dicarboxylate 0.007 mM, 50% inhibition Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.11.2 0.0005
-
 Fe2+
-
 Homo sapiens
1.14.11.2 0.02
-
 2-oxoglutarate
-
 Homo sapiens
1.14.11.2 0.024
-
 (Pro-Pro-Gly)10
-
 Homo sapiens
1.14.11.2 0.37
-
 ascorbate
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.14.11.2 Fe2+ required for activity Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.2 procollagen L-proline + 2-oxoglutarate + O2 Homo sapiens
-
 procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
1.14.11.2 procollagen L-proline + 2-oxoglutarate + O2 Rattus norvegicus
-
 procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
1.14.11.2 procollagen L-proline + 2-oxoglutarate + O2 Mus musculus
-
 procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.2 Homo sapiens Q7Z4N8
-
-
1.14.11.2 Mus musculus Q6W3F0
-
-
1.14.11.2 Rattus norvegicus Q6W3E9
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.11.2 liver adult Homo sapiens
-
1.14.11.2 placenta
-
 Homo sapiens
-
1.14.11.2 skin fetal Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.2 (Pro-Pro-Gly)10 + 2-oxoglutarate + O2
-
 Homo sapiens trans-4-hydroxy-L-proline (Pro-Pro-Gly)10 + succinate + CO2
-
 ?
1.14.11.2 2-oxoglutarate + O2 + ascorbate
-
 Homo sapiens succinate + dehydroascorbate + CO2 + H2O
-
 ?
1.14.11.2 procollagen L-proline + 2-oxoglutarate + O2
-
 Homo sapiens procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
1.14.11.2 procollagen L-proline + 2-oxoglutarate + O2
-
 Rattus norvegicus procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?
1.14.11.2 procollagen L-proline + 2-oxoglutarate + O2
-
 Mus musculus procollagen trans-4-hydroxy-L-proline + succinate + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
1.14.11.2 tetramer probably a alpha(III)2, PDI2 tetramer Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.14.11.2 C-P4H alpha subunit (III)
-
 Homo sapiens
1.14.11.2 C-P4H alpha(III)
-
 Rattus norvegicus
1.14.11.2 C-P4H alpha(III)
-
 Mus musculus