EC Number | Cloned (Comment) | Organism |
---|---|---|
2.4.1.222 | overexpression in S2 cells | Drosophila melanogaster |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.4.1.221 | additional information | down-regulation of enzyme by RNA interference in Notch-secreting cells inhibits both Delta-Notch and Serrate-Notch binding. Overexpression of enzyme in cultured cells increases Serrate-Notch binding but inhibits Delta-Notch binding | Drosophila melanogaster |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.222 | Notch + UDP-D-GlcNAc | Drosophila melanogaster | enzyme completely inhibits binding of Notch protein to its serrate ligands by capping of O-fucose sites, regulation of enzyme activity via expression level in correspondance to the expression level of protein O-fucosyltransferase | beta-D-glucosaminyl-Notch + UDP | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.1.221 | Drosophila melanogaster | - |
- |
- |
2.4.1.222 | Drosophila melanogaster | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.222 | Notch + UDP-D-GlcNAc | enzyme completely inhibits binding of Notch protein to its serrate ligands by capping of O-fucose sites, regulation of enzyme activity via expression level in correspondance to the expression level of protein O-fucosyltransferase | Drosophila melanogaster | beta-D-glucosaminyl-Notch + UDP | - |
? | |
2.4.1.222 | Notch + UDP-D-GlcNAc | Notch protein is O-fucosylated at a serine or threonine residue in the epidermal growth factor-like domain | Drosophila melanogaster | beta-D-glucosaminyl-Notch + UDP | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.4.1.221 | OFUT1 | - |
Drosophila melanogaster |
2.4.1.222 | FNG | - |
Drosophila melanogaster |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.4.1.222 | 30 | - |
assay at | Drosophila melanogaster |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.4.1.222 | 7 | - |
assay at | Drosophila melanogaster |