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Literature summary extracted from

  • Yada, T.; Sato, T.; Kaseyama, H.; Gotoh, M.; Iwasaki, H.; Kikuchi, N.; Kwon, Y.D.; Togayachi, A.; Kudo, T.; Watanabe, H.; Narimatsu, H.; Kimata, K.
    Chondroitin sulfate synthase-3. Molecular cloning and characterization (2003), J. Biol. Chem., 278, 39711-39725.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.175 expression in COS cells Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.175 0.221
-
 UDP-GalNAc
-
 Homo sapiens
2.4.1.175 0.36
-
 chondroitin sulfate CS-11
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.175 membrane type II membrane protein Homo sapiens 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.175 Cd2+ activates Homo sapiens
2.4.1.175 Co2+ divalent cation is essential, Co2+ evokes the highest level of activity Homo sapiens
2.4.1.175 Mn2+ 31% as effective as Co2 in reaction with chondroitin sulfate C11 and UDP-glucuronic acid, 64% as effective as Co2+ in reaction with chondroitin sulfate C10 and UDP-GalNAc Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.175 additional information Homo sapiens CSS3 is a glycosyltransferase having both glucuronyltransferase and N-acetylgalactosaminyltransferase activities. It may make a contribution to CS biosynthesis that differs from that of CSS1 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.175 Homo sapiens Q70JA7
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.175 adrenal gland very low expression level Homo sapiens
-
2.4.1.175 bone marrow very low expression level Homo sapiens
-
2.4.1.175 brain
-
 Homo sapiens
-
2.4.1.175 cerebral cortex
-
 Homo sapiens
-
2.4.1.175 colon very low expression level Homo sapiens
-
2.4.1.175 heart
-
 Homo sapiens
-
2.4.1.175 kidney very low expression level Homo sapiens
-
2.4.1.175 leukocyte very low expression level Homo sapiens
-
2.4.1.175 lung
-
 Homo sapiens
-
2.4.1.175 mammary gland
-
 Homo sapiens
-
2.4.1.175 ovary
-
 Homo sapiens
-
2.4.1.175 pancreas
-
 Homo sapiens
-
2.4.1.175 placenta very low expression level Homo sapiens
-
2.4.1.175 skeletal muscle
-
 Homo sapiens
-
2.4.1.175 small intestine
-
 Homo sapiens
-
2.4.1.175 stomach
-
 Homo sapiens
-
2.4.1.175 testis
-
 Homo sapiens
-
2.4.1.175 thymus very low expression level Homo sapiens
-
2.4.1.175 thyroid gland very low expression level Homo sapiens
-
2.4.1.175 uterus
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.175 chondroitin + UDP-GalNAc chondroitin is the best substrate Homo sapiens ?
-
 ?
2.4.1.175 chondroitin + UDP-glucuronic acid chondroitin is the best substrate Homo sapiens ?
-
 ?
2.4.1.175 chondroitin sulfate A + UDP-GalNAc
-
 Homo sapiens ?
-
 ?
2.4.1.175 chondroitin sulfate A + UDP-glucuronic acid
-
 Homo sapiens ?
-
 ?
2.4.1.175 chondroitin sulfate A10 + UDP-GalNAc no activity with UDP-glucuronic acid Homo sapiens ?
-
 ?
2.4.1.175 chondroitin sulfate A11 + UDP-glucuronic acid no activity with UDP-GalNAc Homo sapiens ?
-
 ?
2.4.1.175 chondroitin sulfate C + UDP-GalNAc
-
 Homo sapiens ?
-
 ?
2.4.1.175 chondroitin sulfate C + UDP-glucuronic acid
-
 Homo sapiens ?
-
 ?
2.4.1.175 chondroitin sulfate C10 + UDP-GalNAc no activity with UDP-glucuronic acid Homo sapiens ?
-
 ?
2.4.1.175 chondroitin sulfate C11 + UDP-glucuronic acid no activity with UDP-GalNAc Homo sapiens ?
-
 ?
2.4.1.175 chondroitin sulfate D + UDP-GalNAc
-
 Homo sapiens ?
-
 ?
2.4.1.175 chondroitin sulfate D + UDP-glucuronic acid
-
 Homo sapiens ?
-
 ?
2.4.1.175 chondroitin sulfate E + UDP-GalNAc
-
 Homo sapiens ?
-
 ?
2.4.1.175 chondroitin sulfate E + UDP-glucuronic acid
-
 Homo sapiens ?
-
 ?
2.4.1.175 dermatan sulfate + UDP-GalNAc
-
 Homo sapiens ?
-
 ?
2.4.1.175 dermatan sulfate + UDP-glucuronic acid
-
 Homo sapiens ?
-
 ?
2.4.1.175 hyaluronan + UDP-GalNAc
-
 Homo sapiens ?
-
 ?
2.4.1.175 hyaluronan + UDP-glucuronic acid
-
 Homo sapiens ?
-
 ?
2.4.1.175 additional information CSS3 is a glycosyltransferase having both glucuronyltransferase and N-acetylgalactosaminyltransferase activities. It may make a contribution to CS biosynthesis that differs from that of CSS1 Homo sapiens ?
-
 ?
2.4.1.175 additional information glucuronyltransferase and N-acetylgalactosaminyltransferase activities are observed when chondroitin, chondroitin sulfate polymer, and their corresponding oligosaccharides are used as the acceptor substrates, reaction products were shown to have a GlcAbeta(1–3)GalNAc linkage and a GalNAbeta(1–4)GlcA linkage in the nonreducing terminus of chondroitin Homo sapiens ?
-
 ?
2.4.1.175 UDP-glucuronic acid + chondroitin sulfate CS-11
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.175 chondroitin sulfate synthase-3
-
 Homo sapiens
2.4.1.175 CSS3
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.175 5.8
-
 Mes buffer, reaction with chondroitin sulfate C11 and UDP-glucuronic acid Homo sapiens
2.4.1.175 6.2
-
 Mes buffer, reaction with chondroitin sulfate C10 and UDP-GalNAc Homo sapiens