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Literature summary extracted from

  • Singh, A.; Venning, J.D.; Quirk, P.G.; van Boxel, G.I.; Rodrigues, D.J.; White, S.A.; Jackson, J.B.
    Interactions between transhydrogenase and thio-nicotinamide Analogues of NAD(H) and NADP(H) underline the importance of nucleotide conformational changes in coupling to proton translocation (2003), J. Biol. Chem., 278, 33208-33216.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.6.1.2 additional information electrochemical gradient forces reaction Rhodospirillum rubrum
1.6.1.2 additional information electrochemical gradient forces reaction Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.6.1.2 dI and native and E155W mutant of dIII expressed in Escherichia coli Rhodospirillum rubrum
1.6.1.2 dIII domain expressed in Escherichia coli Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.6.1.2 dI2dIII complex in its thio-NAD+/NADP+ form Rhodospirillum rubrum
1.6.1.2 dIII domain in its thio-NADP+ form Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.6.1.2 E155W dIII domain, displays similar catalytic properties as wild type, introduced tryptophan fluorescence is sensitive to the redox state of the bound nucleotide Rhodospirillum rubrum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.6.1.2 membrane
-
 Rhodospirillum rubrum 16020
-
1.6.1.2 mitochondrial membrane
-
 Homo sapiens 31966
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.6.1.2 NADH + NADP+ Rhodospirillum rubrum links hydride transfer between NAD(H) and NADP(H) to the outside-in translocation of protons across membrane NAD+ + NADPH
-
 r
1.6.1.2 NADH + NADP+ Homo sapiens links hydride transfer between NAD(H) and NADP(H) to the outside-in translocation of protons across membrane NAD+ + NADPH
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.6.1.2 Homo sapiens Q13423
-
-
1.6.1.2 Rhodospirillum rubrum
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.6.1.2 recombinant protein Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.1.2 heart
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.1.2 NADH + NADP+
-
 Rhodospirillum rubrum NAD+ + NADPH
-
 r
1.6.1.2 NADH + NADP+
-
 Homo sapiens NAD+ + NADPH
-
 r
1.6.1.2 NADH + NADP+ links hydride transfer between NAD(H) and NADP(H) to the outside-in translocation of protons across membrane Rhodospirillum rubrum NAD+ + NADPH
-
 r
1.6.1.2 NADH + NADP+ links hydride transfer between NAD(H) and NADP(H) to the outside-in translocation of protons across membrane Homo sapiens NAD+ + NADPH
-
 r
1.6.1.2 NADH + oxidized 3-acetylpyridine adenine dinucleotide
-
 Rhodospirillum rubrum NAD+ + reduced 3-acetylpyridine adenine dinucleotide
-
 ?
1.6.1.2 NADH + thio-NADP+ good substrate Rhodospirillum rubrum NAD+ + thio-NADPH
-
 r
1.6.1.2 NADPH + oxidized 3-acetylpyridine adenine dinucleotide
-
 Rhodospirillum rubrum NADP+ + reduced 3-acetylpyridine adenine dinucleotide
-
 ?
1.6.1.2 thio-NADH + NADP+ poor substrate Rhodospirillum rubrum thio-NAD+ + NADPH
-
 r

Subunits

EC Number Subunits Comment Organism
1.6.1.2 dimer two monomers with dI, dII, and dIII domain structure Rhodospirillum rubrum
1.6.1.2 dimer two monomers with dI, dII, and dIII domain structure Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.6.1.2 NAD(P)+
-
 Rhodospirillum rubrum
1.6.1.2 NAD(P)+
-
 Homo sapiens
1.6.1.2 NAD(P)H
-
 Rhodospirillum rubrum
1.6.1.2 NAD(P)H
-
 Homo sapiens