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Literature summary extracted from

  • Tipnis, S.R.; Hooper, N.M.; Hyde, R.J.; Christie, G.; Karran, E.; Turner, A.J.
    A humen homolog of angiotensin converting enzyme - cloning and functional expression as a captopril-insensitive carboxypeptidase (2000), J. Biol. Chem., 275, 33238-33243.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.17.23 DNA and amino acid sequence determination, gene maps to choromosomal location Xp22, expression in CHO cells of the wild-type and of the soluble truncated mutant, the latter as c-Myc- and His-tagged protein Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.4.17.23 additional information construction of a soluble truncated mutant enzyme lacking the transmembrane and cytosolic domains Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.17.23 EDTA no inhibition by benzylsuccinate, no inhibition by lisinopril, no inhibition by captopril, no inhibition by enalaprilat Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.17.23 membrane
-
 Homo sapiens 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.17.23 Zn2+ zinc-binding motif HEXXH and third zinc ligand glutamate402, contains zinc-binding consensus sequence HEXXH, amino acids 374-378, zinc-binding protease Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.17.23 92460
-
 DNA sequence determination Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.17.23 angiotensin I + H2O Homo sapiens
-
 angiotensin-(1-9) + Leu
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.23 Homo sapiens Q9BYF1
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.17.23 glycoprotein 7 potential N-glycosylation sites Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.17.23 colon only moderate levels Homo sapiens
-
3.4.17.23 heart
-
 Homo sapiens
-
3.4.17.23 kidney
-
 Homo sapiens
-
3.4.17.23 ovary only moderate levels Homo sapiens
-
3.4.17.23 small intestine only moderate levels Homo sapiens
-
3.4.17.23 testis
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.23 angiotensin I + H2O
-
 Homo sapiens angiotensin-(1-9) + Leu
-
 ?
3.4.17.23 angiotensin I + H2O wild-type and truncated mutant Homo sapiens angiotensin-(1-9) + Leu
-
 ?
3.4.17.23 angiotensin II + H2O wild-type and truncated mutant Homo sapiens angiotensin-(1-7) + Phe
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.17.23 ACEH
-
 Homo sapiens
3.4.17.23 angiotensin-converting enzyme homolog
-
 Homo sapiens
3.4.17.23 angiotensin-converting enzyme-like protein
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.17.23 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.17.23 7.4
-
 assay at Homo sapiens