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Literature summary extracted from

  • Nosjean, O.; Ferro, M.; Coge, F.; Beauverger, P.; et al.
    Identification of the melatonin-binding site MT3 as the quinone reductase 2 (2000), J. Biol. Chem., 275, 31311-31317.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.10.5.1 expression in CHO cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.10.5.1 2-iodomelatonin
-
 Homo sapiens
1.10.5.1 2-iodomelatonin
-
 Mesocricetus auratus
1.10.5.1 5-methoxycarbonylamino-N-acetyltryptamine
-
 Homo sapiens
1.10.5.1 5-methoxycarbonylamino-N-acetyltryptamine
-
 Mesocricetus auratus
1.10.5.1 dicoumarol
-
 Homo sapiens
1.10.5.1 dicoumarol
-
 Mesocricetus auratus
1.10.5.1 Melatonin
-
 Homo sapiens
1.10.5.1 Melatonin
-
 Mesocricetus auratus
1.10.5.1 N-acetylserotonin
-
 Homo sapiens
1.10.5.1 N-acetylserotonin
-
 Mesocricetus auratus
1.10.5.1 S26553
-
 Homo sapiens
1.10.5.1 S26553 i.e. N-methyl-[1-[2-(acetylamino)ethyl]naphthalen-7-yl]-carbamate Mesocricetus auratus
1.10.5.1 serotonin
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.10.5.1 0.0089
-
 menadione pH 7.5 Homo sapiens
1.10.5.1 0.0252
-
 menadione pH 7.5 Mesocricetus auratus
1.10.5.1 0.0576
-
 dihydrobenzylnicotinamide pH 7.5 Homo sapiens
1.10.5.1 0.0608
-
 dihydrobenzylnicotinamide pH 7.5 Mesocricetus auratus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.10.5.1 additional information Homo sapiens enzyme exhibits melatonin-binding activity ?
-
 ?
1.10.5.1 additional information Mesocricetus auratus enzyme exhibits melatonin-binding activity ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.10.5.1 Homo sapiens
-
 expressed in CHO cells
-
1.10.5.1 Mesocricetus auratus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.10.5.1
-
 Homo sapiens
1.10.5.1
-
 Mesocricetus auratus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.10.5.1 kidney
-
 Homo sapiens
-
1.10.5.1 kidney
-
 Mesocricetus auratus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.10.5.1 menadione + dihydrobenzylnicotinamide
-
 Homo sapiens ?
-
 ?
1.10.5.1 menadione + dihydrobenzylnicotinamide
-
 Mesocricetus auratus ?
-
 ?
1.10.5.1 additional information enzyme exhibits melatonin-binding activity Homo sapiens ?
-
 ?
1.10.5.1 additional information enzyme exhibits melatonin-binding activity Mesocricetus auratus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.10.5.1 melatonin-binding site MT3
-
 Homo sapiens
1.10.5.1 melatonin-binding site MT3
-
 Mesocricetus auratus
1.10.5.1 QR2
-
 Homo sapiens
1.10.5.1 quinone reductase 2
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.10.5.1 0.0012
-
 2-iodomelatonin pH 7.5 Mesocricetus auratus
1.10.5.1 0.0028
-
 S26553 pH 7.5 Mesocricetus auratus
1.10.5.1 0.029
-
 2-iodomelatonin pH 7.5 Homo sapiens
1.10.5.1 0.0414
-
 S26553 pH 7.5 Homo sapiens
1.10.5.1 0.043
-
 Melatonin pH 7.5 Mesocricetus auratus
1.10.5.1 0.0435
-
 5-methoxycarbonylamino-N-acetyltryptamine pH 7.5 Mesocricetus auratus
1.10.5.1 0.092
-
 N-acetylserotonin pH 7.5 Mesocricetus auratus
1.10.5.1 0.204
-
 N-acetylserotonin pH 7.5 Homo sapiens
1.10.5.1 0.246
-
 Melatonin pH 7.5 Homo sapiens
1.10.5.1 0.376
-
 5-methoxycarbonylamino-N-acetyltryptamine pH 7.5 Homo sapiens
1.10.5.1 0.566
-
 dicoumarol pH 7.5 Mesocricetus auratus
1.10.5.1 0.62
-
 dicoumarol pH 7.5 Homo sapiens
1.10.5.1 2.933
-
 serotonin
-
 Homo sapiens