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Literature summary extracted from

  • Li-Hawkins, J.; Lund, E.G.; Turley, S.D.; Russell, D.W.
    Disruption of the oxysterol 7alpha-hydroxylase gene in mice (2000), J. Biol. Chem., 275, 16536-16542.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.29 cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 Mus musculus loss of the enzyme in liver is compensated for by increases in the synthesis of bile acids by other pathways cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O
-
 ?
1.14.14.29 cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 Mus musculus loss of the enzyme in liver is compensated for by increases in the synthesis of bile acids by other pathways cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.29 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.29 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.29 cholest-5-ene-3beta,25-diol + NADPH + H+ + O2
-
 Mus musculus cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O
-
 ?
1.14.14.29 cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 loss of the enzyme in liver is compensated for by increases in the synthesis of bile acids by other pathways Mus musculus cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O
-
 ?
1.14.14.29 cholest-5-ene-3beta,27-diol + NADPH + H+ + O2
-
 Mus musculus cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O
-
 ?
1.14.14.29 cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 loss of the enzyme in liver is compensated for by increases in the synthesis of bile acids by other pathways Mus musculus cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.29 CYP7B1
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.29 NADPH
-
 Mus musculus