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Literature summary extracted from

  • Pastuszak, I.; Drake, R.; Elbein, A.D.
    Kidney N-acetylgalactosamine (GalNAc)-1-phosphate kinase, a new pathway of GalNAc activation (1996), J. Biol. Chem., 271, 20776-20782.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.1.157 0.063
-
 ATP
-
 Sus scrofa
2.7.1.157 0.14
-
 N-acetyl-D-galactosamine
-
 Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.157 cytosol
-
 Sus scrofa 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.157 Co2+ divalent cation required, efficiency in descending order: Mg2+ > Mn2+ > Co2+, optimum Co2+ concentration is 10 mM, maximal activity is 50% of that with Mg2+ Sus scrofa
2.7.1.157 Mg2+ divalent cation required, efficiency in descending order: Mg2+ > Mn2+ > Co2+, optimum Mg2+ concentration is 5 mM Sus scrofa
2.7.1.157 Mn2+ divalent cation required, efficiency in descending order: Mg2+ > Mn2+ > Co2+, optimum Mn2+ concentration is 2-8 mM, maximal activity is 50% of that with Mg2+ Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.157 50000
-
 gel filtration Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.157 Homo sapiens
-
-
-
2.7.1.157 Oryctolagus cuniculus
-
-
-
2.7.1.157 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.1.157
-
 Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.157 kidney
-
 Homo sapiens
-
2.7.1.157 kidney
-
 Oryctolagus cuniculus
-
2.7.1.157 kidney highest total and specific activity Sus scrofa
-
2.7.1.157 liver
-
 Sus scrofa
-
2.7.1.157 liver
-
 Oryctolagus cuniculus
-
2.7.1.157 lung
-
 Sus scrofa
-
2.7.1.157 additional information no activity in pancreas, brain, aorta, heart Sus scrofa
-
2.7.1.157 spleen
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.157 1.43
-
-
 Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.157 acetyl-phosphate + N-acetyl-alpha-D-galactosamine 8% of the specific activity with ATP Sus scrofa acetate + N-acetyl-alpha-D-galactosamine 1-phosphate
-
 ?
2.7.1.157 ATP + N-acetyl-alpha-D-galactosamine
-
 Homo sapiens ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
-
 ?
2.7.1.157 ATP + N-acetyl-alpha-D-galactosamine
-
 Sus scrofa ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
-
 ?
2.7.1.157 ATP + N-acetyl-alpha-D-galactosamine
-
 Oryctolagus cuniculus ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
-
 ?
2.7.1.157 ATP + N-acetyl-D-galactosamine
-
 Sus scrofa ADP + N-acetyl-alpha-D-galactosamine 1-phosphate
-
 ?
2.7.1.157 ITP + N-acetyl-alpha-D-galactosamine 9% of the specific activity with ATP Sus scrofa IDP + N-acetyl-alpha-D-galactosamine 1-phosphate
-
 ?
2.7.1.157 phosphoenolpyruvate + N-acetyl-alpha-D-galactosamine 11% of the specific activity with ATP Sus scrofa pyruvate + N-acetyl-alpha-D-galactosamine 1-phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.157 monomer 1 * 50000, SDS-PAGE Sus scrofa

Synonyms

EC Number Synonyms Comment Organism
2.7.1.157 GALK2
-
 Homo sapiens
2.7.1.157 GALK2
-
 Sus scrofa
2.7.1.157 GALK2
-
 Oryctolagus cuniculus
2.7.1.157 GalNAc kinase
-
 Homo sapiens
2.7.1.157 GalNAc kinase
-
 Sus scrofa
2.7.1.157 GalNAc kinase
-
 Oryctolagus cuniculus
2.7.1.157 GK2
-
 Homo sapiens
2.7.1.157 GK2
-
 Sus scrofa
2.7.1.157 GK2
-
 Oryctolagus cuniculus
2.7.1.157 N-acetylgalactosamine (GalNAc)-1-phosphate kinase
-
 Homo sapiens
2.7.1.157 N-acetylgalactosamine (GalNAc)-1-phosphate kinase
-
 Sus scrofa
2.7.1.157 N-acetylgalactosamine (GalNAc)-1-phosphate kinase
-
 Oryctolagus cuniculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.157 8.5 9
-
 Sus scrofa

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.7.1.157 6 10 pH 6.0: about 45% of maximal activity, pH 10.0: about 35% of maximal activity Sus scrofa