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Literature summary extracted from

  • Teixeira, J.; Gil, G.
    Cloning, expression, and regulation of lithocholic acid 6beta-hydroxylase (1991), J. Biol. Chem., 266, 21030-21036.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.14.138 microsome
-
 Mesocricetus auratus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.138 lithocholate + [reduced NADPH-hemoprotein reductase] + O2 Mesocricetus auratus in male hamsters, 6beta-hydroxylation is the major pathway for detoxification of lithocholate. Likely CYP3A10 is responsible for this activity 6beta-hydroxylithocholate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.138 Mesocricetus auratus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.138 liver male-specific enzyme Mesocricetus auratus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.138 lithocholate + [reduced NADPH-hemoprotein reductase] + O2
-
 Mesocricetus auratus 6beta-hydroxylithocholate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.138 lithocholate + [reduced NADPH-hemoprotein reductase] + O2 in male hamsters, 6beta-hydroxylation is the major pathway for detoxification of lithocholate. Likely CYP3A10 is responsible for this activity Mesocricetus auratus 6beta-hydroxylithocholate + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.138 CYP3A10
-
 Mesocricetus auratus
1.14.14.138 lithocholic acid 6beta-hydroxylase
-
 Mesocricetus auratus