Literature summary extracted from

Dales, N.A.; Gould, A.E.; Brown, J.A.; Calderwood, E.F.; Guan, B.; Minor, C.A.; Gavin, J.M.; Hales, P.; Kaushik, V.K.; Stewart, M.; Tummino, P.J.; Vickers, C.S.; Ocain, T.D.; Patane, M.A.
Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors (2002), J. Am. Chem. Soc., 124, 11852-11853.

Application

EC Number	Application	Comment	Organism
3.4.17.23	pharmacology	design and synthesis of first potent and selective enzyme inhibitors may be useful as pharmacological tools to help understanding the biological relevance and potantial role of the enzyme in human disease	Homo sapiens

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.17.23	2-methylphenyl-benzylsuccinic acid	-	Homo sapiens
3.4.17.23	3,4-dimethylphenyl-benzylsuccinic acid	-	Homo sapiens
3.4.17.23	3,5-dichloro-benzylsuccinate	-	Homo sapiens
3.4.17.23	3,5-dimethylphenyl-benzylsuccinic acid	-	Homo sapiens
3.4.17.23	3-methylphenyl-benzylsuccinic acid	-	Homo sapiens
3.4.17.23	4-methylphenyl-benzylsuccinic acid	-	Homo sapiens
3.4.17.23	4-nitrophenyl-benzylsuccinic acid	-	Homo sapiens
3.4.17.23	angiotensin I	-	Homo sapiens
3.4.17.23	Benzylsuccinic acid	-	Homo sapiens
3.4.17.23	cyclohexyl-benzylsuccinic acid	-	Homo sapiens
3.4.17.23	dicyclohexyl-benzylsuccinic acid	-	Homo sapiens
3.4.17.23	additional information	no inhibition by lisinopril, no inhibition by captopril, no inhibition by enalaprilat	Homo sapiens
3.4.17.23	phenylbenzylsuccinic acid	-	Homo sapiens

KM Value [mM]

EC Number	KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
3.4.17.23	0.0069	-	angiotensin I	-	Homo sapiens

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
3.4.17.23	additional information	transmembrane domain	Homo sapiens	-	-

Metals/Ions

EC Number	Metals/Ions	Comment	Organism	Structure
3.4.17.23	Zn2+	contains zinc-binding consensus sequence HEXXH, amino acids 374-378, zinc-binding protease	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.4.17.23	angiotensin I + H2O	Homo sapiens	-	angiotensin-(1-9) + Leu	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.17.23	Homo sapiens	Q9BYF1	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.17.23	colon	-	Homo sapiens	-
3.4.17.23	heart ventricle	-	Homo sapiens	-
3.4.17.23	kidney	-	Homo sapiens	-
3.4.17.23	small intestine	-	Homo sapiens	-
3.4.17.23	testis	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.17.23	angiotensin I + H2O	-	Homo sapiens	angiotensin-(1-9) + Leu	-	?
3.4.17.23	angiotensin I + H2O	C-terminal bond between His-Leu is cleaved	Homo sapiens	angiotensin-(1-9) + Leu	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.17.23	ACE2	-	Homo sapiens
3.4.17.23	angiotensin-converting enzyme homologue	-	Homo sapiens
3.4.17.23	angiotensin-converting enzyme-related carboxypeptidase	-	Homo sapiens

Turnover Number [1/s]

EC Number	Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
3.4.17.23	2	-	angiotensin I	pH 6.5, room temperature	Homo sapiens

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
3.4.17.23	0.0022	-	angiotensin I	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)