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Literature summary extracted from

  • Fang, M.Z.; Jin, Z.; Wang, Y.; Liao, J.; Yang, G.Y.; Wang, L.D.; Yang, C.S.
    Promoter hypermethylation and inactivation of O6-methylguanine-DNA methyltransferase in esophageal squamous cell carcinomas and its reactivation in cell lines (2005), Int. J. Oncol., 26, 615-622.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.1.1.63 medicine DNA hypermethylation and silencing of MGMT are frequent and rather early events in esophageal squamous cell carcinogenesis. Hypermethylation and inactivation of MGMT may be prevented or reversed by dietary polyphenols, (-)-epigallocatechin-3-gallate and genistein, for the prevention of carcinogenesis Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.63 DNA containing 6-O-methylguanine + [protein]-L-cysteine Homo sapiens DNA hypermethylation and silencing of MGMT are frequent and rather early events in esophageal squamous cell carcinogenesis. Hypermethylation and inactivation of MGMT may be prevented or reversed by dietary polyphenols, (-)-epigallocatechin-3-gallate and genistein, for the prevention of carcinogenesis DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.63 Homo sapiens
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-
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.63 esophageal cancer cell esophageal squamous cell carcinoma Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.63 DNA containing 6-O-methylguanine + [protein]-L-cysteine DNA hypermethylation and silencing of MGMT are frequent and rather early events in esophageal squamous cell carcinogenesis. Hypermethylation and inactivation of MGMT may be prevented or reversed by dietary polyphenols, (-)-epigallocatechin-3-gallate and genistein, for the prevention of carcinogenesis Homo sapiens DNA lacking 6-O-methylguanine + [protein]-S-methyl-L-cysteine
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.63 MGMT
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 Homo sapiens
2.1.1.63 O6-methylguanine-DNA methyltransferase
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 Homo sapiens