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Literature summary extracted from

  • Mucha, J.; Svoboda, B.; Kappel, S.; Strasser, R.; Bencur, P.; Froehwein, U.; Schachter, H.; Mach, L.; Gloessl, J.
    Two closely related forms of UDP-GlcNAc:alpha6-D-mannoside beta1,2-N-acetylglucosaminyltransferase II occur in the clawed frog Xenopus laevis (2003), Glycoconj. J., 19, 187-195.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.143 heterologous expression in insect cells Xenopus laevis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.143 membrane enzyme exhibits a type II transmembrane protein topology with a putative N-terminal cytoplasmic tail of 9 amino acids followed by transmembrane domain of 18 residues, and a C-terminal luminal domain of 405 residues Xenopus laevis 16020
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Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.143 UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R Xenopus laevis the enzyme catalyzes an essential step in the biosynthetic pathway leading from high mannose to complex N-linked oligosaccharides UDP + N-acetyl-beta-D-glucosaminyl 1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.143 Xenopus laevis Q7ZZX7 Gnt II-A
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2.4.1.143 Xenopus laevis Q7ZZX7 Gnt II-B
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Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.4.1.143 glycoprotein N-linked oligosaccharides Xenopus laevis

Purification (Commentary)

EC Number Purification (Comment) Organism
2.4.1.143
-
 Xenopus laevis

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.143 heart
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 Xenopus laevis
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2.4.1.143 kidney
-
 Xenopus laevis
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2.4.1.143 liver
-
 Xenopus laevis
-
2.4.1.143 lung
-
 Xenopus laevis
-
2.4.1.143 muscle
-
 Xenopus laevis
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2.4.1.143 ovary
-
 Xenopus laevis
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2.4.1.143 skin
-
 Xenopus laevis
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2.4.1.143 spleen
-
 Xenopus laevis
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.143 UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R the enzyme catalyzes an essential step in the biosynthetic pathway leading from high mannose to complex N-linked oligosaccharides Xenopus laevis UDP + N-acetyl-beta-D-glucosaminyl 1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R
-
 ?
2.4.1.143 UDP-N-acetyl-D-glucosamine + Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta-octyl
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 Xenopus laevis UDP + GlcNAcbeta(1-2)Manalpha(1-6)(GlcNAcbeta(1-2)Manalpha(1-3))Manbeta-octyl
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.143 Gnt II-A
-
 Xenopus laevis
2.4.1.143 Gnt II-B
-
 Xenopus laevis
2.4.1.143 UDP-GlcNAc:alpha6-D-mannoside beta1,2-N-acetylglucosaminyltransferase II
-
 Xenopus laevis