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Literature summary extracted from

  • Heissigerova, H.; Breton, C.; Moravcova, J.; Imberty, A.
    Molecular modeling of glycosyltransferases involved in the biosynthesis of blood group A, blood group B, Forssman, and iGb3 antigens and their interaction with substrates (2003), Glycobiology, 13, 377-386.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.4.1.88 structure determination and molecular modeling on the basis of crystal structure of the bovine alpha3GalT, Protein Data Bank code 1K4V Canis lupus familiaris

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.88 Mn2+
-
 Canis lupus familiaris

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.88 UDP-N-acetyl-D-galactosamine + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-R Canis lupus familiaris production of the Forssman antigen UDP + N-acetyl-D-galactosaminyl-1,3-N-acetyl-D-galactosaminyl-1,3-D-galactosyl-R
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.88 Canis lupus familiaris Q95158
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.4.1.88 UDP-N-acetyl-alpha-D-galactosamine + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-alpha-D-galactosaminyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide catalytic mechanism, substrate binding and active site structure Canis lupus familiaris
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.88 UDP-N-acetyl-D-galactosamine + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-R production of the Forssman antigen Canis lupus familiaris UDP + N-acetyl-D-galactosaminyl-1,3-N-acetyl-D-galactosaminyl-1,3-D-galactosyl-R
-
 ?
2.4.1.88 UDP-N-acetyl-D-galactosamine + N-acetyl-D-galactosaminyl-1,3-D-galactosyl-R substrate binding mechanism, binding site structures and involved amino acids, binding of the nucleotide sugar requires the residues A263, D206, E297, Q296, W295, and S180, binding of the acceptor sugar involves residues H228, Y259, E298, and others, overview Canis lupus familiaris UDP + N-acetyl-D-galactosaminyl-1,3-N-acetyl-D-galactosaminyl-1,3-D-galactosyl-R
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.1.88 More enzyme structure modeling Canis lupus familiaris

Synonyms

EC Number Synonyms Comment Organism
2.4.1.88 Forss-S
-
 Canis lupus familiaris
2.4.1.88 More enzyme belongs to the alpha3-Gal(NAc)T 6 family, i.e. GT6 Canis lupus familiaris