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Literature summary extracted from

  • Park, Y.S.; Koh, Y.H.; Takahashi, M.; Miyamoto, Y.; Suzuki, K.; Dohmae, N.; Takio, K.; Honke, K.; Taniguchi, N.
    Identification of the binding site of methylglyoxal on glutathione peroxidase: methylglyoxal inhibits glutathione peroxidase activity via binding to glutathione binding sites Arg 184 and 185 (2003), Free Radic. Res., 37, 205-211.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.11.1.9 3-deoxyglucosone
-
 Bos taurus
1.11.1.9 Glyoxal
-
 Bos taurus
1.11.1.9 methylglyoxal Arg184 and Arg185, located in the glutathione binding site of the enzyme are irreversibly modified by treatment with methylglyoxal Bos taurus
1.11.1.9 additional information dicarbonyl compounds directly inactivate the enzyme, resulting in an increase in intracellular peroxides, which are responsible for oxidative cellular damage Bos taurus
1.11.1.9 Phenylglyoxal
-
 Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.11.1.9 additional information Bos taurus major antioxidant enzyme ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.11.1.9 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.11.1.9 erythrocyte
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.1.9 additional information major antioxidant enzyme Bos taurus ?
-
 ?
1.11.1.9 tert-butyl hydroperoxide + GSH
-
 Bos taurus tert-butyl alcohol + GSSG + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.11.1.9 GPX
-
 Bos taurus