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Literature summary extracted from

  • Han, Q.; Li, J.
    Cysteine and keto acids modulate mosquito kynurenine aminotransferase catalyzed kynurenic acid production (2004), FEBS Lett., 577, 381-385.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.6.1.7 L-cysteine at 1.25 mM, 3fold stimulation, at 10 mM, 70% inhibition Aedes aegypti

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.7 L-cysteine at 1.25 mM, 3fold stimulation, at 10 mM, 70% inhibition Aedes aegypti

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.7 0.9
-
 L-tyrosine pH 8.5, 45°C Aedes aegypti
2.6.1.7 1.3
-
 L-cysteine pH 8.5, 45°C Aedes aegypti
2.6.1.7 1.4
-
 L-methionine pH 8.5, 45°C Aedes aegypti
2.6.1.7 1.5
-
 L-histidine pH 8.5, 45°C Aedes aegypti
2.6.1.7 3.5
-
 L-phenylalanine pH 8.5, 45°C Aedes aegypti
2.6.1.7 3.8
-
 L-glutamine pH 8.5, 45°C Aedes aegypti
2.6.1.7 4.3
-
 L-kynurenine pH 8.5, 45°C Aedes aegypti
2.6.1.7 6.1
-
 L-asparagine pH 8.5, 45°C Aedes aegypti
2.6.1.7 12.9
-
 L-tryptophan pH 8.5, 45°C Aedes aegypti
2.6.1.7 32.7
-
 L-serine pH 8.5, 45°C Aedes aegypti
2.6.1.7 34.5
-
 L-leucine pH 8.5, 45°C Aedes aegypti
2.6.1.7 92.7
-
 2-aminobutanoate pH 8.5, 45°C Aedes aegypti
2.6.1.7 246
-
 L-alanine pH 8.5, 45°C Aedes aegypti

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.7 Aedes aegypti Q95VY4
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.7 L-alanine + 2-oxobutanoate
-
 Aedes aegypti pyruvate + 2-aminobutanoate
-
 ?
2.6.1.7 L-asparagine + 2-oxobutanoate
-
 Aedes aegypti 2-oxosuccinamic acid + 2-aminobutanoate
-
 ?
2.6.1.7 L-cysteine + 2-oxobutanoate
-
 Aedes aegypti ? + 2-aminobutanoate
-
 ?
2.6.1.7 L-glutamine + 2-oxobutanoate
-
 Aedes aegypti 2-oxoglutarate + 2-aminobutanoate
-
 ?
2.6.1.7 L-histidine + 2-oxobutanoate
-
 Aedes aegypti 3-(1H-imidazol-4-yl)-2-oxopropanoate + 2-aminobutanoate
-
 ?
2.6.1.7 L-kynurenine + 2-oxobutanoate
-
 Aedes aegypti 4-(2-aminophenyl)-2,4-dioxobutanoate + 2-aminobutanoate
-
 ?
2.6.1.7 L-leucine + 2-oxobutanoate
-
 Aedes aegypti alpha-ketoleucine + 2-aminobutanoate
-
 ?
2.6.1.7 L-methionine + 2-oxobutanoate
-
 Aedes aegypti 4-methylsulfanyl-2-oxobutanoate + 2-aminobutanoate
-
 ?
2.6.1.7 L-phenylalanine + 2-oxobutanoate
-
 Aedes aegypti phenylpyruvate + 2-aminobutanoate
-
 ?
2.6.1.7 L-serine + 2-oxobutanoate
-
 Aedes aegypti 3-hydroxy-2-oxopropanoate + 2-aminobutanoate
-
 ?
2.6.1.7 L-tryptophan + 2-oxobutanoate
-
 Aedes aegypti 3-indole-2-oxopropanoate + 2-aminobutanoate
-
 ?
2.6.1.7 L-tyrosine + 2-oxobutanoate
-
 Aedes aegypti 3-(4-hydroxyphenyl)-2-oxopropanoate + 2-aminobutanoate
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.6.1.7 139
-
 L-tyrosine pH 8.5, 45°C Aedes aegypti
2.6.1.7 163
-
 L-methionine pH 8.5, 45°C Aedes aegypti
2.6.1.7 168
-
 L-histidine pH 8.5, 45°C Aedes aegypti
2.6.1.7 172
-
 L-kynurenine pH 8.5, 45°C Aedes aegypti
2.6.1.7 206
-
 L-cysteine pH 8.5, 45°C Aedes aegypti
2.6.1.7 230
-
 L-asparagine pH 8.5, 45°C Aedes aegypti
2.6.1.7 283
-
 L-phenylalanine pH 8.5, 45°C Aedes aegypti
2.6.1.7 283
-
 L-tryptophan pH 8.5, 45°C Aedes aegypti
2.6.1.7 317
-
 2-aminobutanoate pH 8.5, 45°C Aedes aegypti
2.6.1.7 345
-
 L-serine pH 8.5, 45°C Aedes aegypti
2.6.1.7 561
-
 L-glutamine pH 8.5, 45°C Aedes aegypti
2.6.1.7 758
-
 L-leucine pH 8.5, 45°C Aedes aegypti
2.6.1.7 1540
-
 L-alanine pH 8.5, 45°C Aedes aegypti