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Literature summary extracted from

  • Cheng, L.; Tachibana, K.; Iwasaki, H.; Kameyama, A.; Zhang, Y.; Kubota, T.; Hiruma, T.; Kudo, T.; Guo, J.M.; Narimatsu, H.
    Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc-T15 (2004), FEBS Lett., 566, 17-24.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.41 enzyme form pp-GalNAc-T15 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.41 0.016
-
 UDP-N-acetyl-D-galactosamine pH 7.4, 37°C, enzyme form pp-GalNAc-T15 Homo sapiens
2.4.1.41 0.081
-
 UDP-N-acetyl-D-galactosamine pH 7.4, 37°C, enzyme form pp-GalNAc-T2 Homo sapiens
2.4.1.41 0.45
-
 AHGVVTSAPDTR pH 7.4, 37°C, enzyme form pp-GalNAc-T2 Homo sapiens
2.4.1.41 0.91
-
 AHGVVTSAPDTR pH 7.4, 37°C, enzyme form pp-GalNAc-T15 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.41 Homo sapiens Q10471 enzyme form pp-GalNAc-T2
-
2.4.1.41 Homo sapiens Q7Z4T8 enzyme form pp-GalNAc-T15
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.41 brain enzyme form pp-GalNAc-T15 Homo sapiens
-
2.4.1.41 cerebellum enzyme form pp-GalNAc-T15 Homo sapiens
-
2.4.1.41 cerebral cortex enzyme form pp-GalNAc-T15 Homo sapiens
-
2.4.1.41 colon enzyme form pp-GalNAc-T15 Homo sapiens
-
2.4.1.41 kidney enzyme form pp-GalNAc-T15 Homo sapiens
-
2.4.1.41 lung enzyme form pp-GalNAc-T15 Homo sapiens
-
2.4.1.41 mammary gland enzyme form pp-GalNAc-T15 Homo sapiens
-
2.4.1.41 additional information pp-GalNAc-T15 transcript is ubiquitously expressed in human tissues, very low activity in bone marrow, leukocyte, heart, liver, testis, enzyme form pp-GalNAc-T15 Homo sapiens
-
2.4.1.41 ovary enzyme form pp-GalNAc-T15 Homo sapiens
-
2.4.1.41 pancreas enzyme form pp-GalNAc-T15 Homo sapiens
-
2.4.1.41 placenta enzyme form pp-GalNAc-T15 Homo sapiens
-
2.4.1.41 skeletal muscle enzyme form pp-GalNAc-T15 Homo sapiens
-
2.4.1.41 small intestine enzyme form pp-GalNAc-T15 Homo sapiens
-
2.4.1.41 spleen enzyme form pp-GalNAc-T15 Homo sapiens
-
2.4.1.41 stomach enzyme form pp-GalNAc-T15 Homo sapiens
-
2.4.1.41 thymus enzyme form pp-GalNAc-T15 Homo sapiens
-
2.4.1.41 thyroid gland enzyme form pp-GalNAc-T15 Homo sapiens
-
2.4.1.41 uterus enzyme form pp-GalNAc-T15 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.41 UDP-N-acetyl-D-galactosamine + AHGVVTSAPDTR i.e. Muc1, 3% of the activity with Muc5AC as substrate, enzyme form pp-GalNAc-T2 Homo sapiens UDP + ?
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + AHGVVTSAPDTR i.e. Muc1a, enzyme form pp-GalNAc-T15 Homo sapiens UDP + ?
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + ANTPSFPTATSPAPPI i.e. Muc13, about 25% of the activity with Muc5AC as substrate, enzyme form pp-GalNAc-T2 Homo sapiens UDP + ?
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + ANTPSFPTATSPAPPI i.e. Muc13, about 50% of the activity with Muc1a, enzyme form pp-GalNAc-T15 Homo sapiens UDP + ?
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + GTTPSPVPTTSTTSAk i.e. Muc5AC, about 55% of the activity with Muc1a, pp-GalNAc-T15 shows significantly less catalytic activity than pp-GalNAc-T2,T15 transferrs up to seven GalNAcs to the Muc5AC peptide, while T2 transferrs up to five GalNAcs, enzyme form pp-GalNAc-T15 Homo sapiens UDP + ?
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + GTTPSPVPTTSTTSAk i.e. Muc5AC, pp-GalNAc-T15 shows significantly less catalytic activity than pp-GalNAc-T2,T15 transferrs up to seven GalNAcs to the Muc5AC peptide, while T2 transferrs up to five GalNAcs Homo sapiens UDP + ?
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + PTTDSTTPAPTT i.e. EA2, about 25% of the activity with Muc1a, enzyme form pp-GalNAc-T15 Homo sapiens UDP + ?
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + PTTDSTTPAPTT i.e. EA2, about 35% of the activity with Muc5AC as substrate, enzyme form pp-GalNAc-T2 Homo sapiens UDP + ?
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + PTTTPITTTTTVTPTPTPTGTQT i.e. Muc2, about 35% of the activity with Muc1a, enzyme form pp-GalNAc-T15 Homo sapiens UDP + ?
-
 ?
2.4.1.41 UDP-N-acetyl-D-galactosamine + PTTTPITTTTTVTPTPTPTGTQT i.e. Muc2, about 95% of the activity with Muc5AC as substrate, enzyme form pp-GalNAc-T2 Homo sapiens UDP + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.41 pp-GalNAc-T15
-
 Homo sapiens
2.4.1.41 pp-GalNAc-T2
-
 Homo sapiens
2.4.1.41 UDP-GalNAc transferase
-
 Homo sapiens