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Literature summary extracted from

  • Millar, T.M.
    Peroxynitrite formation from the simultaneous reduction of nitrite and oxygen by xanthine oxidase (2004), FEBS Lett., 562, 129-133.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.3.2 allopurinol inhibits peroxynitrite generation, IC50: 0.007 mM Bos taurus
1.17.3.2 diphenylene iodonium inhibits peroxynitrite generation Bos taurus
1.17.3.2 Superoxide dismutase inhibits peroxynitrite generation Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.17.3.2 0.022
-
 hypoxanthine
-
 Bos taurus
1.17.3.2 0.026
-
 O2 with xanthine as cosubstrate Bos taurus
1.17.3.2 0.036
-
 pterin
-
 Bos taurus
1.17.3.2 0.04
-
 nitrite pterin as cosubstrate Bos taurus
1.17.3.2 0.07
-
 nitrite hypoxanthine as cosubstrate Bos taurus
1.17.3.2 0.1
-
 O2 with NADH as cosubstrate Bos taurus
1.17.3.2 1
-
 nitrite with xanthine as cosubstrate Bos taurus
1.17.3.2 1.2
-
 nitrite with NADH as cosubstrate Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
1.17.3.2 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.3.2 milk
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.3.2 nitrite + NADH
-
 Bos taurus NO + NAD+ + H2O
-
 ?
1.17.3.2 nitrite + O2 + hypoxanthine
-
 Bos taurus peroxynitrite + ?
-
 ?
1.17.3.2 nitrite + O2 + pterin
-
 Bos taurus peroxynitrite + ?
-
 ?
1.17.3.2 nitrite + xanthine
-
 Bos taurus NO + ?
-
 ?
1.17.3.2 xanthine + H2O + O2
-
 Bos taurus urate + H2O2
-
 ?

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.17.3.2 0.007
-
 inhibits peroxynitrite generation, IC50: 0.007 mM Bos taurus allopurinol