Literature summary extracted from

Chuman, Y.; Bergman, A.; Ueno, T.; Saito, S.; Sakaguchi, K.; Alaiya, A.A.; Franzen, B.; Bergman, T.; Arnott, D.; Auer, G.; Appella, E.; Jornvall, H.; Linder, S.
Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas (1999), FEBS Lett., 462, 129-134.

Application

EC Number	Application	Comment	Organism
3.4.23.B1	analysis	enzyme is a specific marker in diagnosis of primary lung adenocarcinoma and to distinguish it from metastatic adenocarcinoma	Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.4.23.B1	polypeptide + H2O	Homo sapiens	-	peptides	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.23.B1	Homo sapiens	O96009	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
3.4.23.B1	alveolar cell type II	pneumocyte type II	Homo sapiens	-
3.4.23.B1	kidney	fetal, low expression level	Homo sapiens	-
3.4.23.B1	leukocyte	of peripheral blood	Homo sapiens	-
3.4.23.B1	lung	high expression level, adult and fetal lung	Homo sapiens	-
3.4.23.B1	lung adenocarcinoma cell	high expression level	Homo sapiens	-
3.4.23.B1	peripheral blood	-	Homo sapiens	-
3.4.23.B1	promyelocytic leukemia cell line	-	Homo sapiens	-
3.4.23.B1	RAJI cell	-	Homo sapiens	-
3.4.23.B1	spleen	adult	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.23.B1	polypeptide + H2O	-	Homo sapiens	peptides	-	?

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Release 2023.1 (January 2023)