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Literature summary extracted from

  • Trevino, S.G.; Schuschereba, S.T.; Bowman, P.D.; Tsin, A.
    Lecithin:retinol acyltransferase in ARPE-19 (2005), Exp. Eye Res., 80, 897-900.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.1.135 analysis ARPE-19 cell system is appropriate for studying the visual cycle enzymes Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.135 retinyl bromoacetate 78% reduction of enzyme activity Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.135 0.0095
-
all-trans-retinol
-
Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.135 membrane
-
Homo sapiens 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.135 25000
-
x * 25000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.135 phosphatidylcholine + all-trans-retinol-[cellular-retinol-binding-protein] Homo sapiens enzyme is involved in the visual cycle in the eye 2-acylglycerophosphocholine + all-trans-retinyl-ester-[cellular-retinol-binding-protein]
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.135 Homo sapiens
-
-
-
2.3.1.135 no activity in Gallus gallus
-
not found in glial cells
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.135 ARPE-19 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.135 phosphatidylcholine + all-trans-retinol
-
Homo sapiens 2-acylglycerophosphocholine + all-trans-retinyl acylester
-
?
2.3.1.135 phosphatidylcholine + all-trans-retinol-[cellular-retinol-binding-protein]
-
Homo sapiens 2-acylglycerophosphocholine + all-trans-retinyl-ester-[cellular-retinol-binding-protein]
-
?
2.3.1.135 phosphatidylcholine + all-trans-retinol-[cellular-retinol-binding-protein] enzyme is involved in the visual cycle in the eye Homo sapiens 2-acylglycerophosphocholine + all-trans-retinyl-ester-[cellular-retinol-binding-protein]
-
?

Subunits

EC Number Subunits Comment Organism
2.3.1.135 ? x * 25000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.3.1.135 lecithin:retinol acyltransferase
-
Homo sapiens
2.3.1.135 LRAT
-
Homo sapiens