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Literature summary extracted from

  • Xin, H.W.; Fischer, C.; Schwab, M.; Klotz, U.
    Thiopurine S-methyltransferase as a target for drug interactions (2005), Eur. J. Clin. Pharmacol., 61, 395-398.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.67 Azathioprine IC50: 0.43-0.532 mM Homo sapiens
2.1.1.67 Furosemide IC50: 0.015-0.019 mM, has the potential to inhibit thiopurine S-methyltransferase in patients with chronic inflammatory bowel disease Homo sapiens
2.1.1.67 piretanide IC50: 0.3-0.313 mM Homo sapiens
2.1.1.67 testosterone IC50: 0.03-0.072 mM Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.67 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.67 erythrocyte from patients with chronic inflammatory bowel disease Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.67 S-adenosyl-L-methionine + 6-thioguanine
-
 Homo sapiens S-adenosyl-L-homocysteine + 6-methylthioguanine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.67 TPMT
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.1.1.67 0.015 0.019 IC50: 0.015-0.019 mM, has the potential to inhibit thiopurine S-methyltransferase in patients with chronic inflammatory bowel disease Homo sapiens Furosemide
2.1.1.67 0.03 0.072 IC50: 0.03-0.072 mM Homo sapiens testosterone
2.1.1.67 0.3 0.313 IC50: 0.3-0.313 mM Homo sapiens piretanide
2.1.1.67 0.43 0.532 IC50: 0.43-0.532 mM Homo sapiens Azathioprine