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Literature summary extracted from

  • Ferry, G.; Ubeaud, C.; Mozo, J.; Pean, C.; Hennig, P.; Rodriguez, M.; Scoul, C.; Bonnaud, A.; Nosjean, O.; Galizzi, J.P.; Delagrange, P.; Renard, P.; Volland, J.P.; Yous, S.; Lesieur, D.; Boutin, J.A.
    New substrate analogues of human serotonin N-acetyltransferase produce in situ specific and potent inhibitors (2004), Eur. J. Biochem., 271, 418-428.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.87 expression in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.87 2-bromo-N-[2-(5-fluoro-1-benzothien-3-yl)ethyl]acetamide IC50: 0.00039 mM Homo sapiens
2.3.1.87 bromoacetyltryptamine IC50: 0.0014 mM Homo sapiens
2.3.1.87 methyl 3-[2-[(bromoacetyl)amino]ethyl]-1-benzothiophene-5-carboxylate IC50: 0.00225 mM Homo sapiens
2.3.1.87 N-[2-(2-benzyl-5-methoxy-benzofuran-3-yl)ethyl]iodoacetamide IC50: 0.0087 mM Homo sapiens
2.3.1.87 N-[2-(2-phenyl-benzo [b]thiophen-3-yl)ethyl]bromoacetamide IC50: 0.001 mM Homo sapiens
2.3.1.87 N-[2-(3-ethyl-7-methoxy-napht-1-yl)ethyl]iodoacetamide IC50: 0.0006 mM Homo sapiens
2.3.1.87 N-[2-(5-bromo-benzo[b]thiophen-3-yl)ethyl]bromoacetamide IC50: 0.00378 mM Homo sapiens
2.3.1.87 N-[2-(5-chloro-benzo[b]thiophen-3-yl)ethyl]bromoacetamide IC50: 0.00018 mM Homo sapiens
2.3.1.87 N-[2-(5-ethyl-1-benzothien-3-yl)ethyl]-2-iodoacetamide IC50: 0.002 mM Homo sapiens
2.3.1.87 N-[2-(5-ethyl-benzo[b]thiophen-3-yl)ethyl]bromoacetamide IC50: 0.00071 mM Homo sapiens
2.3.1.87 N-[2-(5-fluoro-1H-indol-3-yl)ethyl]bromoacetamide IC50: 0.0056 mM Homo sapiens
2.3.1.87 N-[2-(5-hydroxy-benzo[b]thiophen-3-yl)ethyl]bromoacetamide IC50: 0.00018 mM Homo sapiens
2.3.1.87 N-[2-(7-ethyl-1,2,3,4-tetrahydronapht-1-yl)ethyl]iodooacetamide IC50: above 0.1 mM Homo sapiens
2.3.1.87 N-[2-(7-ethyl-napht-1-yl)ethyl]-bromoacetamide IC50: 0.00177 mM Homo sapiens
2.3.1.87 N-[2-(7-hydroxy-naphth-1-yl)ethyl]bromoacetamide IC50: 0.00072 mM Homo sapiens
2.3.1.87 N-[2-(7-methoxy-3-(3-trifluoromethylphenyl)-napht-1-yl)ethyl]iodoacetamide IC50: 0.045 mM Homo sapiens
2.3.1.87 N-[2-(7-methoxy-8-propenyl-napht-1-yl)ethyl]-iodoacetamide IC50: above 0.1 mM Homo sapiens
2.3.1.87 N-[2-(7-methoxy-napht-1-yl)ethyl]bromoacetamide IC50: 0.002 mM Homo sapiens
2.3.1.87 N-[2-(7-propoxy-napht-1-yl)ethyl]iodoacetamide IC50: 0.0042 mM Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.87 additional information Homo sapiens the enzyme catalyzes the rate-limiting step in melatonin synthesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.87 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.87 acetyl-CoA + phenylethylamine
-
 Homo sapiens CoA + N-acetyl-phenylethylamine
-
 ?
2.3.1.87 additional information the enzyme catalyzes the rate-limiting step in melatonin synthesis Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.87 arylalkylamine N-acetyltransferase
-
 Homo sapiens
2.3.1.87 serotonin N-acetyltransferase
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.87 0.00018
-
 IC50: 0.00018 mM Homo sapiens N-[2-(5-hydroxy-benzo[b]thiophen-3-yl)ethyl]bromoacetamide
2.3.1.87 0.00018
-
 IC50: 0.00018 mM Homo sapiens N-[2-(5-chloro-benzo[b]thiophen-3-yl)ethyl]bromoacetamide
2.3.1.87 0.00039
-
 IC50: 0.00039 mM Homo sapiens 2-bromo-N-[2-(5-fluoro-1-benzothien-3-yl)ethyl]acetamide
2.3.1.87 0.0006
-
 IC50: 0.0006 mM Homo sapiens N-[2-(3-ethyl-7-methoxy-napht-1-yl)ethyl]iodoacetamide
2.3.1.87 0.00071
-
 IC50: 0.00071 mM Homo sapiens N-[2-(5-ethyl-benzo[b]thiophen-3-yl)ethyl]bromoacetamide
2.3.1.87 0.00072
-
 IC50: 0.00072 mM Homo sapiens N-[2-(7-hydroxy-naphth-1-yl)ethyl]bromoacetamide
2.3.1.87 0.001
-
 IC50: 0.001 mM Homo sapiens N-[2-(2-phenyl-benzo [b]thiophen-3-yl)ethyl]bromoacetamide
2.3.1.87 0.0014
-
 IC50: 0.0014 mM Homo sapiens bromoacetyltryptamine
2.3.1.87 0.00177
-
 IC50: 0.00177 mM Homo sapiens N-[2-(7-ethyl-napht-1-yl)ethyl]-bromoacetamide
2.3.1.87 0.002
-
 IC50: 0.002 mM Homo sapiens N-[2-(7-methoxy-napht-1-yl)ethyl]bromoacetamide
2.3.1.87 0.002
-
 IC50: 0.002 mM Homo sapiens N-[2-(5-ethyl-1-benzothien-3-yl)ethyl]-2-iodoacetamide
2.3.1.87 0.00225
-
 IC50: 0.00225 mM Homo sapiens methyl 3-[2-[(bromoacetyl)amino]ethyl]-1-benzothiophene-5-carboxylate
2.3.1.87 0.00378
-
 IC50: 0.00378 mM Homo sapiens N-[2-(5-bromo-benzo[b]thiophen-3-yl)ethyl]bromoacetamide
2.3.1.87 0.0042
-
 IC50: 0.0042 mM Homo sapiens N-[2-(7-propoxy-napht-1-yl)ethyl]iodoacetamide
2.3.1.87 0.0056
-
 IC50: 0.0056 mM Homo sapiens N-[2-(5-fluoro-1H-indol-3-yl)ethyl]bromoacetamide
2.3.1.87 0.0087
-
 IC50: 0.0087 mM Homo sapiens N-[2-(2-benzyl-5-methoxy-benzofuran-3-yl)ethyl]iodoacetamide
2.3.1.87 0.045
-
 IC50: 0.045 mM Homo sapiens N-[2-(7-methoxy-3-(3-trifluoromethylphenyl)-napht-1-yl)ethyl]iodoacetamide
2.3.1.87 0.1
-
 IC50: above 0.1 mM Homo sapiens N-[2-(7-ethyl-1,2,3,4-tetrahydronapht-1-yl)ethyl]iodooacetamide
2.3.1.87 0.1
-
 IC50: above 0.1 mM Homo sapiens N-[2-(7-methoxy-8-propenyl-napht-1-yl)ethyl]-iodoacetamide