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Literature summary extracted from

  • Couto, A.S.; Caffaro, C.; Uhrig, M.L.; Kimura, E.; Peres, V.J.; Merino, E.F.; Katzin, A.M.; Nishioka, M.; Nonami, H.; Erra-Balsells, R.
    Glycosphingolipids in Plasmodium falciparum. Presence of an active glucosylceramide synthase (2004), Eur. J. Biochem., 271, 2204-2214.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.4.1.80 pharmacology enzyme might be an attractive target for malarial chemotherapy Plasmodium falciparum

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.80 D,L-threo-1-phenyl-2-palmitoylamino-3-morpholino-1-propanol enzyme inhibition in vitro and in vivo, in the latter case the compound also inhibits growth of the parasite Plasmodium falciparum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.80 additional information Plasmodium falciparum lipid profile of the parasite at different developmental stages, overview ?
-
 ?
2.4.1.80 UDP-glucose + N-acylsphingosine Plasmodium falciparum key step in biosynthesis of glycosphingolipids UDP + D-glucosyl-N-acylsphingosine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.80 Plasmodium falciparum
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.80 additional information intraerythrocytic stages of the parasite Plasmodium falciparum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.80 additional information lipid profile of the parasite at different developmental stages, overview Plasmodium falciparum ?
-
 ?
2.4.1.80 UDP-glucose + dihydroceramide mono-, tri-, and tetrahexosylceramides, the parasite enzyme is only active on the saturated substrate Plasmodium falciparum UDP + D-glucosyl-dihydroceramide product analysis ?
2.4.1.80 UDP-glucose + N-acylsphingosine
-
 Plasmodium falciparum UDP + D-glucosyl-N-acylsphingosine
-
 ?
2.4.1.80 UDP-glucose + N-acylsphingosine key step in biosynthesis of glycosphingolipids Plasmodium falciparum UDP + D-glucosyl-N-acylsphingosine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.80 GCS
-
 Plasmodium falciparum
2.4.1.80 glucosylceramide synthase
-
 Plasmodium falciparum

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.80 37
-
 assay at Plasmodium falciparum

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.80 7.4
-
 assay at Plasmodium falciparum