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Literature summary extracted from

  • Pemberton, A.D.; Zamolodchikova, T.S.; Scudamore, C.L.; Chilvers, E.R.; Miller, H.R.; Walker, T.R.
    Proteolytic action of duodenase is required to induce DNA synthesis in pulmonary artery fibroblasts (2002), Eur. J. Biochem., 269, 1171-1180.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.B3 Trypsin inhibitor from soybean Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.B3 polypeptide + H2O Bos taurus
-
 peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.B3 Bos taurus P80219
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.B3 at least 90% purity Bos taurus

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.21.B3 proteolytic cleavage of polypeptides to large and stable peptides, preferential cleavage sites: Lys-, Arg-, Tyr-, Phe-, Leu-, -Pro serine protease which has a dual specificity, i.e. both trypsin-like and chymotrypsin-like activities Bos taurus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.B3 epithelium
-
 Bos taurus
-
3.4.21.B3 fibroblast from pulmonary artery Bos taurus
-
3.4.21.B3 jejunum intestinal mucosa Bos taurus
-
3.4.21.B3 lamina propria
-
 Bos taurus
-
3.4.21.B3 lung around brochioles and within alveolar septa Bos taurus
-
3.4.21.B3 mast cell spindle or stellate-shaped, located pricipally in the lamina propria and submucosa Bos taurus
-
3.4.21.B3 mucosa
-
 Bos taurus
-
3.4.21.B3 pulmonary artery endothelial cell fibroblast Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.B3 polypeptide + H2O
-
 Bos taurus peptides
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.B3 duodenase I
-
 Bos taurus
3.4.21.B3 duodenase serine protease
-
 Bos taurus