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Literature summary extracted from

  • Xia, L.; Björnstedt, M.; Nordman, T.; Eriksson, L.C.; Olsson, J.M.
    Reduction of ubiquinone by lipoamide dehydrogenase. An antioxidant regenerating pathway (2001), Eur. J. Biochem., 268, 1486-1490.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.4 NAD(P)+ product inhibition Sus scrofa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.8.1.4 Cd2+ highly, specifically stimulating for ubiquinone reduction, optimal at 0.5 mM Sus scrofa
1.8.1.4 Zn2+ highly, specifically stimulating for ubiquinone reduction, optimal at 0.5 mM, Zn2+ slightly elevates the pH-optimum of the enzyme Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.8.1.4 55000
-
 2 * 55000, about, SDS-PAGE Sus scrofa
1.8.1.4 115000
-
 gel filtration Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.1.4 ubiquinone + NAD(P)H Sus scrofa
-
 ubiquinol + NAD(P)+
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.4 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.4 commercial preparation purified enzyme Sus scrofa
-
1.8.1.4 heart
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.8.1.4 0.002
-
 purified enzyme in absence of Zn2+ Sus scrofa
1.8.1.4 0.05
-
 purified enzyme in presence of Zn2+ Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.4 ubiquinone + NAD(P)H
-
 Sus scrofa ubiquinol + NAD(P)+
-
 ir

Subunits

EC Number Subunits Comment Organism
1.8.1.4 dimer 2 * 55000, about, SDS-PAGE Sus scrofa

Synonyms

EC Number Synonyms Comment Organism
1.8.1.4 lipoamide dehydrogenase
-
 Sus scrofa

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.8.1.4 37
-
 assay at Sus scrofa

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.8.1.4 72
-
 ubiquinone pH 7.5, 37°C, in absence of Zn2+ Sus scrofa
1.8.1.4 300
-
 ubiquinone pH 7.5, 37°C, in presence of Zn2+ Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.8.1.4 5.5
-
 optimum in absence of Zn2+ Sus scrofa
1.8.1.4 6
-
 optimum in presence of Zn2+ Sus scrofa

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.4 FAD
-
 Sus scrofa
1.8.1.4 NAD(P)H NADPH and NADH are equally effective as cofactors Sus scrofa