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Literature summary extracted from

  • Garcia-Salcedo, J.A.; Gijon, P.; Nolan, D.P.; Tebabi, P.; Pays, E.
    A chromosomal SIR2 homologue with both histone NAD-dependent ADP-ribosyltransferase and deacetylase activities is involved in DNA repair in Trypanosoma brucei (2003), EMBO J., 22, 5851-5862.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.2.30
-
 Trypanosoma brucei

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.2.30 chromatin TbSIR2RP1 is a nuclear protein that colocalizes with telomeric sequences and minichromosomes Trypanosoma brucei 785
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.30 NAD+ + histone H2A Trypanosoma brucei the enzyme catalyses both ADP-ribosylation and deacetylation of histones, particulary H2A and H2B. Histone modification by TbSIR2RP1 is involved in DNA repair nicotinamide + (ADP-D-ribosyl)-histone H2A
-
 ?
2.4.2.30 NAD+ + histone H2B Trypanosoma brucei the enzyme catalyses both ADP-ribosylation and deacetylation of histones, particulary H2A and H2B. Histone modification by TbSIR2RP1 is involved in DNA repair nicotinamide + (ADP-D-ribosyl)-histone H2B
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.30 Trypanosoma brucei
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.30 NAD+ + histone H2A the enzyme catalyses both ADP-ribosylation and deacetylation of histones, particulary H2A and H2B. Histone modification by TbSIR2RP1 is involved in DNA repair Trypanosoma brucei nicotinamide + (ADP-D-ribosyl)-histone H2A
-
 ?
2.4.2.30 NAD+ + histone H2A the enzyme catalyses both ADP-ribosylation and deacetylation of histones, particulary H2A and H2B Trypanosoma brucei nicotinamide + (ADP-D-ribosyl)-histone H2A
-
 ?
2.4.2.30 NAD+ + histone H2B the enzyme catalyses both ADP-ribosylation and deacetylation of histones, particulary H2A and H2B. Histone modification by TbSIR2RP1 is involved in DNA repair Trypanosoma brucei nicotinamide + (ADP-D-ribosyl)-histone H2B
-
 ?
2.4.2.30 NAD+ + histone H2B the enzyme catalyses both ADP-ribosylation and deacetylation of histones, particulary H2A and H2B Trypanosoma brucei nicotinamide + (ADP-D-ribosyl)-histone H2B
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.30 NAD-dependent ADP-ribosyltransferase
-
 Trypanosoma brucei
2.4.2.30 TbSIR2RP1
-
 Trypanosoma brucei