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Literature summary extracted from

  • Soars, M.G.; Ring, B.J.; Wrighton, S.A.
    The effect of incubation conditions on the enzyme kinetics of UDP-glucuronosyltransferases (2003), Drug Metab. Dispos., 31, 762-767.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.17 alamethicin
-
 Homo sapiens
2.4.1.17 Brij58
-
 Homo sapiens
2.4.1.17 additional information sonication activates Homo sapiens
2.4.1.17 phosphate activity in phosphate buffer is higher than in Tris/malate buffer containing 5 mM sucrose Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.17 additional information
-
 additional information kinetics, at different conditions with different activators and different substrates, microsomes or recombinant isozymes, overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 microsome
-
 Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.17 Mg2+
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens
-
 isozymes UGT1A1, UGT1A6, UGT1A9, UGT2B7, and UGT2B15
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 liver
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.1.17 additional information
-
 activity at different conditions with different activators and different substrates, microsomes or recombinant isozymes, overview Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 additional information substrate specificities of different isozymes Homo sapiens ?
-
 ?
2.4.1.17 UDP-glucuronate + 3,17-estradiol isozyme UGT1A1 Homo sapiens UDP + 17-estradiol 3-O-glucuronide
-
 ?
2.4.1.17 UDP-glucuronate + 3,17-estradiol isozyme UGT1A1 Homo sapiens UDP + 3-estradiol 17-O-glucuronide
-
 ?
2.4.1.17 UDP-glucuronate + androstane-3,17-diol isozyme UGT2B15 Homo sapiens UDP + androstane-3,17-diol 17-O-beta-D-glucuronide
-
 ?
2.4.1.17 UDP-glucuronate + anthraflavic acid isozyme UGT1A1 Homo sapiens UDP + anthraflavic acid 2-glucuronide
-
 ?
2.4.1.17 UDP-glucuronate + buprenorphine isozyme UGT1A1 Homo sapiens UDP + buprenorphine glucuronide
-
 ?
2.4.1.17 UDP-glucuronate + ethinylestradiol isozyme UGT1A1 Homo sapiens UDP + ethinylestradiol glucuronide
-
 ?
2.4.1.17 UDP-glucuronate + morphine isozyme UGT1A1 Homo sapiens UDP + morphine-3-beta-D-glucuronide
-
 ?
2.4.1.17 UDP-glucuronate + morphine isozyme UGT1A1 Homo sapiens UDP + morphine-6-beta-D-glucuronide
-
 ?
2.4.1.17 UDP-glucuronate + naphthol isozyme UGT1A6 Homo sapiens UDP + naphthol glucuronide
-
 ?
2.4.1.17 UDP-glucuronate + propofol isozyme UGT1A9 Homo sapiens UDP + propofol beta-D-glucuronide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.17 UDP-glucuronosyltransferase
-
 Homo sapiens
2.4.1.17 UGT
-
 Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.17 7.1 7.4 assay at Homo sapiens