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Literature summary extracted from

  • Court, M.H.; Krishnaswamy, S.; Hao, Q.; Duan, S.X.; Patten, C.J.; Von Moltke, L.L.; Greenblatt, D.J.
    Evaluation of 3'-azido-3'-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: specificity and influence of the UGT2B7*2 polymorphism (2003), Drug Metab. Dispos., 31, 1125-1133.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.17 additional information
-
 additional information kinetics, different isozymes Homo sapiens
2.4.1.17 0.4
-
 codeine isozyme UGT2B7, pH 7.5, 37°C Homo sapiens
2.4.1.17 0.63
-
 morphine morphine 6-glucuronide formation, isozyme UGT2B7, pH 7.5, 37°C Homo sapiens
2.4.1.17 0.67
-
 morphine morphine 3-glucuronide formation, isozyme UGT2B7, pH 7.5, 37°C Homo sapiens
2.4.1.17 0.77
-
 3'-azido-3'-deoxythymidine isozyme UGT2B7, pH 7.5, 37°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 microsome
-
 Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.1.17 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.17 additional information Homo sapiens isozyme UGT2B7 is involved in glucuronidation of a wide array of clinically important drugs and endogenous compounds in humans ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens
-
 several isozymes
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 liver
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.4.1.17 additional information
-
 activities with morphine, codeine, and 3'-azido-3'-deoxythymidine of different isozymes Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 additional information isozyme UGT2B7 is involved in glucuronidation of a wide array of clinically important drugs and endogenous compounds in humans Homo sapiens ?
-
 ?
2.4.1.17 additional information the UGT2B7*2 polymorphism is not a determinant of glucuronodation specificity, substrate specificity by isozyme UGT2B7, overview Homo sapiens ?
-
 ?
2.4.1.17 UDP-glucuronate + 3'-azido-3'-deoxythymidine isozymes UGT2B4, UGT2B7, and UGT2B17 Homo sapiens UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronide
-
 ?
2.4.1.17 UDP-glucuronate + codeine isozymes UGT2B4 and UGT2B7 Homo sapiens UDP + codeine beta-D-glucuronide
-
 ?
2.4.1.17 UDP-glucuronate + morphine isozyme UGT2B7, low activity with isozymes UGT1A3, UGT1A10, UGT2B4 and UGT1A9 Homo sapiens UDP + morphine-3-beta-D-glucuronide
-
 ?
2.4.1.17 UDP-glucuronate + morphine isozymes UGT2B4 and UGT2B7, low activity with isozymes UGT1A1, and UGT1A3 Homo sapiens UDP + morphine-6-beta-D-glucuronide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.17 More enzyme belongs to the 2B subfamily Homo sapiens
2.4.1.17 UDP-glucuronosyltransferase
-
 Homo sapiens
2.4.1.17 UDP-glucuronosyltransferase 2B7
-
 Homo sapiens
2.4.1.17 UGT
-
 Homo sapiens
2.4.1.17 UGT2B7
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.1.17 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.1.17 7.5
-
 assay at Homo sapiens