Literature summary extracted from

Huang, J.K.; Tsai, S.; Huang, G.H.; Sershon, V.C.; Alley, A.M.; Wen, L.
Molecular cloning of bovine eIF5A and deoxyhypusine synthase cDNA (2004), DNA Seq., 15, 26-32.

Cloned(Commentary)

EC Number	Cloned (Comment)	Organism
2.5.1.46	-	Bos taurus

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2.5.1.46	[eIF5A-precursor]-lysine + spermidine	Bos taurus	deoxyhypusine synthase is the first of the two enzymes that catalyze the maturation of eukaryotic initiation factor 5A. Synthesis of hypusine is essential for the function of eIF5A in eukaryotic cell proliferation and survival	[eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.5.1.46	Bos taurus	Q6EWQ6	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.5.1.46	testis	-	Bos taurus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.5.1.46	[eIF5A-precursor]-lysine + spermidine	deoxyhypusine synthase is the first of the two enzymes that catalyze the maturation of eukaryotic initiation factor 5A. Synthesis of hypusine is essential for the function of eIF5A in eukaryotic cell proliferation and survival	Bos taurus	[eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine	-	?

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Release 2023.1 (January 2023)