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Literature summary extracted from

  • Lu, Q.; Harrington, E.O.; Hai, C.M.; Newton, J.; Garber, M.; Hirase, T.; Rounds, S.
    Isoprenylcysteine carboxyl methyltransferase modulates endothelial monolayer permeability: involvement of RhoA carboxyl methylation (2004), Circ. Res., 94, 306-315.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.100 adenosine plus homocysteine Bos taurus
2.1.1.100 N-acetyl-S-geranylgeranyl-L-cysteine
-
 Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.100 S-adenosyl-L-methionine + (RhoAA) C-terminal S-farnesyl-L-cysteine Bos taurus the enzyme modulates endothelial monolayer per meability by altering RhoA carboxyl methylation and activation, thus changing the organization of intercellular junctions. Carboxy methylation of RhoA may modulate endothelial barrier function S-adenosyl-L-homocysteine + (RhoA) C-terminal S-farnesyl-L-cysteine methyl ester
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.100 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.100 pulmonary artery endothelial cell stably overexpressing isoprenylcysteine carboxyl methyltransferase/GFP cDNA Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.100 S-adenosyl-L-methionine + (RhoAA) C-terminal S-farnesyl-L-cysteine
-
 Bos taurus S-adenosyl-L-homocysteine + (RhoA) C-terminal S-farnesyl-L-cysteine methyl ester
-
 ?
2.1.1.100 S-adenosyl-L-methionine + (RhoAA) C-terminal S-farnesyl-L-cysteine the enzyme modulates endothelial monolayer per meability by altering RhoA carboxyl methylation and activation, thus changing the organization of intercellular junctions. Carboxy methylation of RhoA may modulate endothelial barrier function Bos taurus S-adenosyl-L-homocysteine + (RhoA) C-terminal S-farnesyl-L-cysteine methyl ester
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.100 Icmt
-
 Bos taurus
2.1.1.100 isoprenylcysteine carboxyl methyltransferase
-
 Bos taurus