EC Number | Cloned (Comment) | Organism |
---|---|---|
3.4.17.23 | gene ACE2, DNA sequence determination and analysis, expression in CHO K1 cells, secretion of the active enzyme from transfected cells by cleavage N-terminal to the transmembrane domain | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.17.23 | additional information | no inhibition by captopril | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.4.17.23 | membrane | enzyme possesses a transmembrane domain, posttranslational cleavage for secretion of the protein in vivo and in cell culture | Homo sapiens | 16020 | - |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.4.17.23 | additional information | metalloprotease | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.17.23 | angiotensin I + H2O | Homo sapiens | - |
angiotensin-(1-9) + Leu | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.17.23 | Homo sapiens | Q9BYF1 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.4.17.23 | recombinant from CHO K1 cells | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.17.23 | epithelium | of coronary and intrarenal vessels and renal tubuls | Homo sapiens | - |
3.4.17.23 | heart ventricle | - |
Homo sapiens | - |
3.4.17.23 | testis | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.17.23 | angiotensin I + H2O | - |
Homo sapiens | angiotensin-(1-9) + Leu | - |
? | |
3.4.17.23 | angiotensin I + H2O | no angiotensin-converting activity, i.e. no conversion of the decapeptide angiotensin I to the octapeptide angiotensin II | Homo sapiens | angiotensin-(1-9) + Leu | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.17.23 | ACE-related carboxypeptidase | - |
Homo sapiens |
3.4.17.23 | ACE2 | - |
Homo sapiens |