Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Donoghue, M.; Hsieh, F.; Baronas, E.; Godbout, K.; Gosselin, M.; Stagliano, N.; Donovan, M.; Woolf, B.; Robison, K.; Jeyaseelan, R.; Breitbart, R.E.; Acton, S.
    A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9 (2000), Circ. Res., 87, E1-9.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.17.23 gene ACE2, DNA sequence determination and analysis, expression in CHO K1 cells, secretion of the active enzyme from transfected cells by cleavage N-terminal to the transmembrane domain Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.17.23 additional information no inhibition by captopril Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.17.23 membrane enzyme possesses a transmembrane domain, posttranslational cleavage for secretion of the protein in vivo and in cell culture Homo sapiens 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.17.23 additional information metalloprotease Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.17.23 angiotensin I + H2O Homo sapiens
-
 angiotensin-(1-9) + Leu
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.17.23 Homo sapiens Q9BYF1
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.17.23 recombinant from CHO K1 cells Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.17.23 epithelium of coronary and intrarenal vessels and renal tubuls Homo sapiens
-
3.4.17.23 heart ventricle
-
 Homo sapiens
-
3.4.17.23 testis
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.23 angiotensin I + H2O
-
 Homo sapiens angiotensin-(1-9) + Leu
-
 ?
3.4.17.23 angiotensin I + H2O no angiotensin-converting activity, i.e. no conversion of the decapeptide angiotensin I to the octapeptide angiotensin II Homo sapiens angiotensin-(1-9) + Leu
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.17.23 ACE-related carboxypeptidase
-
 Homo sapiens
3.4.17.23 ACE2
-
 Homo sapiens