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Literature summary extracted from

  • Walton, F.S.; Waters, S.B.; Jolley, S.L.; LeCluyse, E.L.; Thomas, D.J.; Styblo, M.
    Selenium compounds modulate the activity of recombinant rat AsIII-methyltransferase and the methylation of arsenite by rat and human hepatocytes (2003), Chem. Res. Toxicol., 16, 261-265.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.1.137 dimethylselenoxide weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes Homo sapiens
2.1.1.137 dimethylselenoxide weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes Rattus norvegicus
2.1.1.137 trimethyl-selenonium iodide weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes Homo sapiens
2.1.1.137 trimethylselenonium iodide weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.137 dimethylselenoxide weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes Homo sapiens
2.1.1.137 dimethylselenoxide weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes Rattus norvegicus
2.1.1.137 methylselenic acid
-
 Homo sapiens
2.1.1.137 methylselenic acid
-
 Rattus norvegicus
2.1.1.137 Sodium selenite
-
 Homo sapiens
2.1.1.137 Sodium selenite
-
 Rattus norvegicus
2.1.1.137 trimethyl-selenonium iodide weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes Homo sapiens
2.1.1.137 trimethylselenonium iodide weak activator of recombinant As(III)-methyltransferase, weak inhibitor of arsenite methylation in hepatocytes Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.137 Homo sapiens
-
-
-
2.1.1.137 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.137 hepatocyte
-
 Homo sapiens
-
2.1.1.137 hepatocyte
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.137 S-adenosyl-L-methionine + arsenite
-
 Homo sapiens S-adenosyl-L-homocysteine + methylarsonate
-
 ?
2.1.1.137 S-adenosyl-L-methionine + arsenite
-
 Rattus norvegicus S-adenosyl-L-homocysteine + methylarsonate
-
 ?
2.1.1.137 S-adenosyl-L-methionine + methylarsonite
-
 Homo sapiens S-adenosyl-L-homocysteine + dimethylarsinate
-
 ?
2.1.1.137 S-adenosyl-L-methionine + methylarsonite
-
 Rattus norvegicus S-adenosyl-L-homocysteine + dimethylarsinate
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.1.137 0.0014
-
 Sodium selenite
-
 Rattus norvegicus
2.1.1.137 0.0194
-
 methylselenic acid
-
 Rattus norvegicus