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Literature summary extracted from

  • Stiborova, M.; Frei, E.; Sopko, B.; Sopkova, K.; Markova, V.; Lankova, M.; Kumstyrova, T.; Wiessler, M.; Schmeiser, H.H.
    Human cytosolic enzymes involved in the metabolic activation of carcinogenic aristolochic acid: evidence for reductive activation by human NAD(P)H:quinone oxidoreductase (2003), Carcinogenesis, 24, 1695-1703.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.6.5.2 cytosol
-
 Homo sapiens 5829
-
1.6.5.2 cytosol
-
 Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.6.5.2 additional information Homo sapiens the enzyme is involved in the metabolic activation of carcinogenic aristolochic acid ?
-
 ?
1.6.5.2 additional information Rattus norvegicus the enzyme is involved in the metabolic activation of carcinogenic aristolochic acid ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.6.5.2 Homo sapiens
-
-
-
1.6.5.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.5.2 kidney
-
 Homo sapiens
-
1.6.5.2 kidney
-
 Rattus norvegicus
-
1.6.5.2 liver
-
 Homo sapiens
-
1.6.5.2 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.5.2 2-methyl-1,4-naphthoquinone + NADH
-
 Homo sapiens 2-methyl-1,4-naphthoquinol + NAD+
-
 ?
1.6.5.2 2-methyl-1,4-naphthoquinone + NADH
-
 Rattus norvegicus 2-methyl-1,4-naphthoquinol + NAD+
-
 ?
1.6.5.2 2-methyl-1,4-naphthoquinone + NADPH
-
 Homo sapiens 2-methyl-1,4-naphthoquinol + NADp+
-
 ?
1.6.5.2 2-methyl-1,4-naphthoquinone + NADPH
-
 Rattus norvegicus 2-methyl-1,4-naphthoquinol + NADp+
-
 ?
1.6.5.2 additional information the enzyme is involved in the metabolic activation of carcinogenic aristolochic acid Homo sapiens ?
-
 ?
1.6.5.2 additional information the enzyme is involved in the metabolic activation of carcinogenic aristolochic acid Rattus norvegicus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.6.5.2 NAD(P)H:quinone oxidoreductase
-
 Rattus norvegicus
1.6.5.2 NQO1
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.6.5.2 NADH
-
 Homo sapiens
1.6.5.2 NADH
-
 Rattus norvegicus
1.6.5.2 NADPH
-
 Homo sapiens
1.6.5.2 NADPH
-
 Rattus norvegicus