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Literature summary extracted from

  • Fang, M.Z.; Wang, Y.; Ai, N.; Hou, Z.; Sun, Y.; Lu, H.; Welsh, W.; Yang, C.S.
    Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines (2003), Cancer Res., 63, 7563-7570.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.37 (-)-epigallocatechin-3-gallate competitive, the inhibitor can form hydrogen bonds with Pro1223, Glu1265, Cys1225, Ser1229 and Arg1309. Hypermethylation of CpG islands in the promoter regions is an important mechanism to silence the expression of many important genes in cancer. (-)-Epigallocatechin-3-gallate can inhibit DNMT activity and reactivate methylation-silenced genes in cancer cells Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.37 S-adenosyl-L-methionine + DNA Homo sapiens hypermethylation of CpG islands in the promoter regions is an important mechanism to silence the expression of many important genes in cancer S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.37 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.37 HT-29 cell colon cancer Homo sapiens
-
2.1.1.37 KYSE-150 cell esophageal cancer Homo sapiens
-
2.1.1.37 PC-3 cell prostate cancer Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.37 S-adenosyl-L-methionine + DNA hypermethylation of CpG islands in the promoter regions is an important mechanism to silence the expression of many important genes in cancer Homo sapiens S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine
-
?
2.1.1.37 S-adenosyl-L-methionine + poly(dI-dC)/poly(dI-dC)
-
Homo sapiens S-adenosyl-L-homocysteine + poly(dI-dC)/poly(dI-dC) containing 5-methylcytosine
-
?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.37 5-cytosine DNA methyltransferase
-
Homo sapiens
2.1.1.37 DNMT
-
Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.1.1.37 0.00689
-
(-)-epigallocatechin-3-gallate substrate: poly(dI-dC)/poly(dI-dC) Homo sapiens