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Literature summary extracted from

  • Lackner, M.R.; Kindt, R.M.; Carroll, P.M.; Brown, K.; Cancilla, M.R.; Chen, C.; de Silva, H.; Franke, Y.; Guan, B.; Heuer, T.; Hung, T.; Keegan, K.; Lee, J.M.; Manne, V.; O'Brien, C.; Parry, D.; Perez-Villar, J.J.; Reddy, R.K.; Xiao, H.; Zhan, H.; Cockett, M.; Plowman, G.; Fitzgerald, K.; Costa, M.; Ross-Macdonald, P.
    Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors (2005), Cancer Cell, 7, 325-336.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.5.1.60 medicine RabGGT is a therapeutically relevant target for modulation of apoptosis Homo sapiens
2.5.1.60 medicine RabGGT is a therapeutically relevant target for modulation of apoptosis Caenorhabditis elegans

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.60 BMS1
-
 Caenorhabditis elegans
2.5.1.60 BMS2
-
 Caenorhabditis elegans
2.5.1.60 BMS3
-
 Caenorhabditis elegans
2.5.1.60 BMS4
-
 Caenorhabditis elegans

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.60 additional information Homo sapiens reduction in RabGGT function can be sufficient to induce cancer cell lines to undergo p53-independent apoptosis ?
-
 ?
2.5.1.60 additional information Caenorhabditis elegans reduction in RabGGT function can be sufficient to induce cancer cell lines to undergo p53-independent apoptosis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.60 Caenorhabditis elegans
-
-
-
2.5.1.60 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.60 breast cancer cell
-
 Homo sapiens
-
2.5.1.60 colonic cancer cell adenocarcinoma of colon, significant overexpression of RabGGT-beta compared to normal tissue Homo sapiens
-
2.5.1.60 kidney tumor cell
-
 Homo sapiens
-
2.5.1.60 lung cancer cell large cell lung carcinomas, significant overexpression of RabGGT-beta compared to normal tissue Homo sapiens
-
2.5.1.60 melanoma cell significant overexpression of RabGGT-beta and Rab-GGT-alpha compared to normal tissue Homo sapiens
-
2.5.1.60 ovary cancer cell significant overexpression of RabGGT-beta and RabGGT-alpha compared to normal tissue Homo sapiens
-
2.5.1.60 prostate cancer cell
-
 Homo sapiens
-
2.5.1.60 uterine cancer cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.60 additional information reduction in RabGGT function can be sufficient to induce cancer cell lines to undergo p53-independent apoptosis Homo sapiens ?
-
 ?
2.5.1.60 additional information reduction in RabGGT function can be sufficient to induce cancer cell lines to undergo p53-independent apoptosis Caenorhabditis elegans ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.60 Rab geranylgeranyl transferase
-
 Homo sapiens
2.5.1.60 Rab geranylgeranyl transferase
-
 Caenorhabditis elegans
2.5.1.60 RabGGT
-
 Homo sapiens
2.5.1.60 RabGGT
-
 Caenorhabditis elegans