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Literature summary extracted from

  • Sigle, J.P.; Zander, J.; Ehret, A.; Honegger, J.; Jackisch, R.; Feuerstein, T.J.
    High potassium-induced activation of choline-acetyltransferase in human neocortex: implications and species differences (2003), Brain Res. Bull., 60, 255-262.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.6 bromo-acetylcholine
-
 Homo sapiens
2.3.1.6 bromo-acetylcholine
-
 Mus musculus
2.3.1.6 ocadaic acid
-
 Homo sapiens
2.3.1.6 ocadaic acid
-
 Mus musculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.1.6 K+ highest activity at 10-20 mM K+ Homo sapiens
2.3.1.6 additional information addition of K+ does not affect activity Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.6 acetyl-CoA + choline Mus musculus synthesis of the neurotransmitter acetylcholine acetylcholine + CoA
-
 r
2.3.1.6 acetyl-CoA + choline Homo sapiens synthesis of the neurotransmitter acetylcholine acetylcholine + CoA
-
 r

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.6 Homo sapiens
-
-
-
2.3.1.6 Mus musculus
-
 B6 CBA wild type mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.6 neocortex
-
 Mus musculus
-
2.3.1.6 neocortex
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.6 acetyl-CoA + choline
-
 Mus musculus acetylcholine + CoA
-
 r
2.3.1.6 acetyl-CoA + choline
-
 Homo sapiens acetylcholine + CoA
-
 r
2.3.1.6 acetyl-CoA + choline synthesis of the neurotransmitter acetylcholine Mus musculus acetylcholine + CoA
-
 r
2.3.1.6 acetyl-CoA + choline synthesis of the neurotransmitter acetylcholine Homo sapiens acetylcholine + CoA
-
 r