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Literature summary extracted from

  • Coxon, F.P.; Ebetino, F.H.; Mules, E.H.; Seabra, M.C.; McKenna, C.E.; Rogers, M.J.
    Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo (2005), Bone, 37, 349-358.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.60 2-(3-pyridinyl)-1-ethylidene-1,1-phosphonocarboxylic acid causes rapid accumulation of unprenylated Rabs within the cytosol of osteoclasts and macrophages due to specific inhibition of Rab GGTase Mus musculus
2.5.1.60 2-(3-pyridinyl)-1-hydroxyethylidene-1,1-bisphosphonic acid causes rapid accumulation of unprenylated Rabs within the cytosol of osteoclasts and macrophages due to specific inhibition of Rab GGTase Mus musculus
2.5.1.60 2-(3-pyridinyl)-1-hydroxyethylidene-1,1-phosphonocarboxylic acid causes rapid accumulation of unprenylated Rabs within the cytosol of osteoclasts and macrophages due to specific inhibition of Rab GGTase Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.60 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.60 J774.2 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.60 geranylgeranyl diphosphate + Rab-protein-cysteine
-
 Mus musculus S-geranylgeranyl-Rab-protein + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.60 Rab geranylgeranyl transferase
-
 Mus musculus
2.5.1.60 Rab GGTase
-
 Mus musculus