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Literature summary extracted from
- Development of a large-scale continuous substrate to feed process for the biotransformation of simvastatin by Nocardia sp. (1991), Biotechnol. Bioeng., 37, 1101-1107.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.14.14.1 | synthesis | production of 6-beta-hydroxy-methyl-simvastatin, simvastatin and derivatives belong to the family of HMG-CoA reductase inhibitors, which are potent cholesterol-lowering therapeutic agents | Pseudonocardia autotrophica |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.1 | Pseudonocardia autotrophica | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.1 | simvastatin + [reduced NADPH-hemoprotein reductase] + O2 | - |
Pseudonocardia autotrophica | 6-beta-hydroxy-methyl-simvastatin + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |  |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.14.14.1 | 27 | - |
- |
Pseudonocardia autotrophica |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.14.1 | 6.8 | - |
- |
Pseudonocardia autotrophica |
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Release 2023.1 (January 2023)
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