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Literature summary extracted from

  • Hillig, I.; Warnecke, D.; Heinz, E.
    An inhibitor of glucosylceramide synthase inhibits the human enzyme, but not enzymes from other organisms (2005), Biosci. Biotechnol. Biochem., 69, 1782-1785.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.80 expression in an enzyme-deficient strain of Pichia pastoris Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.80 (D-threo)-1-(3',4'-ethylenedioxy)phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol the inhibitor is abolutely specific for the recombinant human enzyme and does not affect recombinant non-human enzymes from Gossypium arboreum, Caenorhabditis elegans, Aspergillus nidulans, Candida albicans, Pichia pastoris, Ustilago maydis, or Agrobacterium tumefaciens Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.80 membrane bound Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.80 UDP-glucose + ceramide Homo sapiens
-
 UDP + glucosylceramide glucosylceramide is a precursor for synthesis of a multitude of higher sphingolipids ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.80 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.80 UDP-glucose + ceramide
-
 Homo sapiens UDP + glucosylceramide
-
 ?
2.4.1.80 UDP-glucose + ceramide
-
 Homo sapiens UDP + glucosylceramide glucosylceramide is a precursor for synthesis of a multitude of higher sphingolipids ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.80 GCS
-
 Homo sapiens
2.4.1.80 glucosylceramide synthase
-
 Homo sapiens