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Literature summary extracted from

  • Kung, P.P.; Zehnder, L.R.; Meng, J.J.; Kupchinsky, S.W.; Skalitzky, D.J.; Johnson, M.C.; Maegley, K.A.; Ekker, A.; Kuhn, L.A.; Rose, P.W.; Bloom, L.A.
    Design, synthesis, and biological evaluation of novel human 5'-deoxy-5'-methylthioadenosine phosphorylase (MTAP) substrates (2005), Bioorg. Med. Chem. Lett., 15, 2829-2833.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.2.28 0.00088
-
 5'-deoxy-5'-pyridin-2-yl-sulfanyladenosine
-
 Homo sapiens
2.4.2.28 0.00102
-
 5'-deoxy-5'-cyclohexyl-thioadenosine
-
 Homo sapiens
2.4.2.28 0.0015
-
 5'-deoxy-5'-(3-methylphenyl)-thioadenosine
-
 Homo sapiens
2.4.2.28 0.0017
-
 5'-deoxy-5'-(4-methylphenyl)-thioadenosine
-
 Homo sapiens
2.4.2.28 0.0018
-
 5'-deoxy-5'-methyl-thioadenosine
-
 Homo sapiens
2.4.2.28 0.0018
-
 5'-deoxy-5'-isobutylthioadenosine
-
 Homo sapiens
2.4.2.28 0.002
-
 5'-deoxy-5'-(2-methylphenyl)-thioadenosine
-
 Homo sapiens
2.4.2.28 0.0028
-
 5'-deoxy-5'-(2-methylbutyl)-thioadenosine
-
 Homo sapiens
2.4.2.28 0.003
-
 5'-deoxy-5'-imidazol-2-yl-sulfanyladenosine
-
 Homo sapiens
2.4.2.28 0.0031
-
 2'-deoxy-5'-deoxy-5'-methylthioadenosine
-
 Homo sapiens
2.4.2.28 0.0031
-
 5'-deoxy-5'-butylthioadenosine
-
 Homo sapiens
2.4.2.28 0.0032
-
 5'-deoxy-5'-(4-methoxyphenyl)-thioadenosine
-
 Homo sapiens
2.4.2.28 0.0034
-
 5'-deoxy-5'-(phenylmethyl)-thioadenosine
-
 Homo sapiens
2.4.2.28 0.0035
-
 5'-deoxy-5'-cyclopentyl-thioadenosine
-
 Homo sapiens
2.4.2.28 0.0039
-
 3'-deoxy-5'-deoxy-5'-methylthioadenosine
-
 Homo sapiens
2.4.2.28 0.004
-
 5'-deoxy-5'-hydroxyethylthioadenosine
-
 Homo sapiens
2.4.2.28 0.0046
-
 5'-deoxy-5'-(phenylethyl)-thioadenosine
-
 Homo sapiens
2.4.2.28 0.005
-
 5'-deoxy-5'-(2-(pyridin-2-yl)ethyl)-thioadenosine
-
 Homo sapiens
2.4.2.28 0.005
-
 5'-deoxy-5'-pyridin-4-yl-sulfanyladenosine
-
 Homo sapiens
2.4.2.28 0.0052
-
 5'-deoxy-5'-(quinolin-2-yl)-sulfanyladenosine
-
 Homo sapiens
2.4.2.28 0.006
-
 5'-deoxy-adenosine
-
 Homo sapiens
2.4.2.28 0.0069
-
 5'-deoxy-5'-phenyl-thioadenosine
-
 Homo sapiens
2.4.2.28 0.007
-
 5'-deoxy-5'-[4-(trifluoromethyl)phenyl]-thioadenosine
-
 Homo sapiens
2.4.2.28 0.009
-
 5'-deoxy-5'-(1,3-thiazol)-2-yl-sulfanyladenosine
-
 Homo sapiens
2.4.2.28 0.017
-
 5'-deoxy-5'-isopentylthioadenosine
-
 Homo sapiens
2.4.2.28 0.025
-
 5'-deoxy-5'-tert-butylthioadenosine
-
 Homo sapiens
2.4.2.28 0.03
-
 5'-deoxy-5'-ethylthioadenosine
-
 Homo sapiens
2.4.2.28 3.6
-
 2'-deoxy-2'-azido-5'-deoxy-5'-methylthioadenosine
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.28 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.28 2'-deoxy-2'-amino-5'-deoxy-5'-methylthioadenosine + phosphate
-
 Homo sapiens adenine + 2-deoxy-2-amino-5-thio-D-ribose 1-phosphate
-
 ?
2.4.2.28 2'-deoxy-2'-azido-5'-deoxy-5'-methylthioadenosine + phosphate
-
 Homo sapiens adenine + 2-deoxy-2-azido-5-thio-D-ribose 1-phosphate
-
 ?
2.4.2.28 2'-deoxy-2-fluoro-5'-deoxy-5'-methylthioadenosine + phosphate
-
 Homo sapiens adenine + 2-deoxy-2-fluoro-5-thio-D-ribose 1-phosphate
-
 ?
2.4.2.28 2'-deoxy-5'-deoxy-5'-methylthioadenosine + phosphate
-
 Homo sapiens adenine + 2-deoxy-5-thio-D-ribose 1-phosphate
-
 ?
2.4.2.28 3'-deoxy-5'-deoxy-5'-methylthioadenosine + phosphate
-
 Homo sapiens adenine + 3-deoxy-5-thio-D-ribose 1-phosphate
-
 ?
2.4.2.28 5'-deoxy-5'-(1,3-thiazol)-2-yl-sulfanyladenosine + phosphate
-
 Homo sapiens adenine + 5-(1,3-thiazol-2-yl)thio-D-ribose 1-phosphate
-
 ?
2.4.2.28 5'-deoxy-5'-(2-(pyridin-2-yl)ethyl)-thioadenosine + phosphate
-
 Homo sapiens adenine + 5-ethylthio-D-ribose 1-phosphate
-
 ?
2.4.2.28 5'-deoxy-5'-(2-methylbutyl)-thioadenosine + phosphate
-
 Homo sapiens adenine + 5-(2-methylbutyl)thio-D-ribose 1-phosphate
-
 ?
2.4.2.28 5'-deoxy-5'-(2-methylphenyl)-thioadenosine + phosphate
-
 Homo sapiens adenine + 5-(2-methylphenyl)thio-D-ribose 1-phosphate
-
 ?
2.4.2.28 5'-deoxy-5'-(3-methylphenyl)-thioadenosine + phosphate
-
 Homo sapiens adenine + 5-(3-methylphenyl)thio-D-ribose 1-phosphate
-
 ?
2.4.2.28 5'-deoxy-5'-(4-methoxyphenyl)-thioadenosine + phosphate
-
 Homo sapiens adenine + 5-(4-methoxyphenyl)thio-D-ribose 1-phosphate
-
 ?
2.4.2.28 5'-deoxy-5'-(4-methylphenyl)-thioadenosine + phosphate
-
 Homo sapiens adenine + 5-(4-methylphenyl)thio-D-ribose 1-phosphate
-
 ?
2.4.2.28 5'-deoxy-5'-(phenylethyl)-thioadenosine + phosphate
-
 Homo sapiens adenine + 5-phenylethylthio-D-ribose 1-phosphate
-
 ?
2.4.2.28 5'-deoxy-5'-(phenylmethyl)-thioadenosine + phosphate
-
 Homo sapiens adenine + 5-phenylmethylthio-D-ribose 1-phosphate
-
 ?
2.4.2.28 5'-deoxy-5'-(quinolin-2-yl)-sulfanyladenosine + phosphate
-
 Homo sapiens adenine + 5-(quinolin-2-yl)thio-D-ribose 1-phosphate
-
 ?
2.4.2.28 5'-deoxy-5'-butylthioadenosine + phosphate
-
 Homo sapiens adenine + 5-butylthio-D-ribose 1-phosphate
-
 ?
2.4.2.28 5'-deoxy-5'-cyclohexyl-thioadenosine + phosphate
-
 Homo sapiens adenine + 5-cyclohexylthio-D-ribose 1-phosphate
-
 ?
2.4.2.28 5'-deoxy-5'-cyclopentyl-thioadenosine + phosphate
-
 Homo sapiens adenine + 5-cyclopentylthio-D-ribose 1-phosphate
-
 ?
2.4.2.28 5'-deoxy-5'-ethylthioadenosine + phosphate
-
 Homo sapiens adenine + 5-ethylthio-D-ribose 1-phosphate
-
 ?
2.4.2.28 5'-deoxy-5'-hydroxyethylthioadenosine + phosphate
-
 Homo sapiens adenine + 5-(2-hydroxyethyl)thio-D-ribose 1-phosphate
-
 ?
2.4.2.28 5'-deoxy-5'-imidazol-2-yl-sulfanyladenosine + phosphate
-
 Homo sapiens adenine + 5-(imidazol-2-yl)thio-D-ribose 1-phosphate
-
 ?
2.4.2.28 5'-deoxy-5'-isobutylthioadenosine + phosphate
-
 Homo sapiens adenine + 5-isobutylthio-D-ribose 1-phosphate
-
 ?
2.4.2.28 5'-deoxy-5'-isopentylthioadenosine + phosphate
-
 Homo sapiens adenine + 5-isopentylthio-D-ribose 1-phosphate
-
 ?
2.4.2.28 5'-deoxy-5'-methyl-thioadenosine + phosphate
-
 Homo sapiens adenine + 5-methylthio-D-ribose 1-phosphate
-
 ?
2.4.2.28 5'-deoxy-5'-phenyl-thioadenosine + phosphate
-
 Homo sapiens adenine + 5-phenylthio-D-ribose 1-phosphate
-
 ?
2.4.2.28 5'-deoxy-5'-phenylmethylene-adenosine + phosphate
-
 Homo sapiens adenine + 5-deoxy-5-phenylmethylene-D-ribose 1-phosphate
-
 ?
2.4.2.28 5'-deoxy-5'-pyridin-2-yl-sulfanyladenosine + phosphate
-
 Homo sapiens adenine + 5-(pyridin-2-yl)thio-D-ribose 1-phosphate
-
 ?
2.4.2.28 5'-deoxy-5'-pyridin-4-yl-sulfanyladenosine + phosphate
-
 Homo sapiens adenine + 5-(pyridin-4-yl)thio-D-ribose 1-phosphate
-
 ?
2.4.2.28 5'-deoxy-5'-tert-butylthioadenosine + phosphate
-
 Homo sapiens adenine + 5-tert-butylthio-D-ribose 1-phosphate
-
 ?
2.4.2.28 5'-deoxy-5'-[4-(trifluoromethyl)phenyl]-thioadenosine + phosphate
-
 Homo sapiens adenine + 5-[4-(trifluoromethyl)phenyl]thio-D-ribose 1-phosphate
-
 ?
2.4.2.28 5'-deoxy-5'phenylaminoadenosine + phosphate
-
 Homo sapiens adenine + 5-deoxy-5-phenylamino-D-ribose 1-phosphate
-
 ?
2.4.2.28 5'-deoxy-adenosine + phosphate
-
 Homo sapiens adenine + 5-thio-D-ribose 1 phosphate
-
 ?
2.4.2.28 5'-phenyladenosine + phosphate
-
 Homo sapiens adenine + 5-phenyl-D-ribose 1-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.28 5'-deoxy-5'-methylthioadenosine phosphorylase
-
 Homo sapiens
2.4.2.28 MTAP
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.4.2.28 0.0004
-
 2'-deoxy-2-fluoro-5'-deoxy-5'-methylthioadenosine
-
 Homo sapiens
2.4.2.28 0.004
-
 3'-deoxy-5'-deoxy-5'-methylthioadenosine
-
 Homo sapiens
2.4.2.28 0.04
-
 2'-deoxy-2'-azido-5'-deoxy-5'-methylthioadenosine
-
 Homo sapiens
2.4.2.28 0.23
-
 5'-deoxy-5'-pyridin-2-yl-sulfanyladenosine
-
 Homo sapiens
2.4.2.28 0.28
-
 2'-deoxy-5'-deoxy-5'-methylthioadenosine
-
 Homo sapiens
2.4.2.28 0.3
-
 5'-deoxy-5'-(4-methylphenyl)-thioadenosine
-
 Homo sapiens
2.4.2.28 0.67
-
 5'-deoxy-5'-ethylthioadenosine
-
 Homo sapiens
2.4.2.28 0.8
-
 5'-deoxy-5'-[4-(trifluoromethyl)phenyl]-thioadenosine
-
 Homo sapiens
2.4.2.28 0.85
-
 5'-deoxy-5'-isopentylthioadenosine
-
 Homo sapiens
2.4.2.28 1.01
-
 5'-deoxy-5'-cyclohexyl-thioadenosine
-
 Homo sapiens
2.4.2.28 1.4
-
 5'-deoxy-5'-(3-methylphenyl)-thioadenosine
-
 Homo sapiens
2.4.2.28 1.46
-
 5'-deoxy-5'-tert-butylthioadenosine
-
 Homo sapiens
2.4.2.28 1.5
-
 5'-deoxy-5'-imidazol-2-yl-sulfanyladenosine
-
 Homo sapiens
2.4.2.28 1.5
-
 5'-deoxy-5'-(4-methoxyphenyl)-thioadenosine
-
 Homo sapiens
2.4.2.28 1.57
-
 5'-deoxy-5'-cyclopentyl-thioadenosine
-
 Homo sapiens
2.4.2.28 2.14
-
 5'-deoxy-5'-(2-(pyridin-2-yl)ethyl)-thioadenosine
-
 Homo sapiens
2.4.2.28 2.3
-
 5'-deoxy-5'-butylthioadenosine
-
 Homo sapiens
2.4.2.28 2.4
-
 5'-deoxy-5'-(2-methylphenyl)-thioadenosine
-
 Homo sapiens
2.4.2.28 2.49
-
 5'-deoxy-5'-(phenylmethyl)-thioadenosine
-
 Homo sapiens
2.4.2.28 2.5
-
 5'-deoxy-5'-(phenylethyl)-thioadenosine
-
 Homo sapiens
2.4.2.28 2.9
-
 5'-deoxy-5'-isobutylthioadenosine
-
 Homo sapiens
2.4.2.28 3.16
-
 5'-deoxy-5'-phenyl-thioadenosine
-
 Homo sapiens
2.4.2.28 3.44
-
 5'-deoxy-5'-(quinolin-2-yl)-sulfanyladenosine
-
 Homo sapiens
2.4.2.28 3.8
-
 5'-deoxy-5'-(1,3-thiazol)-2-yl-sulfanyladenosine
-
 Homo sapiens
2.4.2.28 4.2
-
 5'-deoxy-5'-pyridin-4-yl-sulfanyladenosine
-
 Homo sapiens
2.4.2.28 4.6
-
 5'-deoxy-5'-methyl-thioadenosine
-
 Homo sapiens
2.4.2.28 4.8
-
 5'-deoxy-adenosine
-
 Homo sapiens
2.4.2.28 5.5
-
 5'-deoxy-5'-(2-methylbutyl)-thioadenosine
-
 Homo sapiens
2.4.2.28 5.9
-
 5'-deoxy-5'-hydroxyethylthioadenosine
-
 Homo sapiens