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Literature summary extracted from

  • Hamilton, C.J.; Saravanamuthu, A.; Fairlamb, A.H.; Eggleston, I.M.
    Benzofuranyl 3,5-bis-polyamine derivatives as time-dependent inhibitors of trypanothione reductase (2003), Bioorg. Med. Chem., 11, 3683-3693.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.12 bis(tetrahydrocinnamoyl)spermine i.e. kukoamine A Trypanosoma cruzi
1.8.1.12 lunarine Lunaria derived alkaloid with a unusual 3-oxohexahydrodibenzofuranyl tricyclic scaffold, competitive, reversible formation of a covalent adduct between Cys53 and one of the alpha,beta-unsaturated amide groups of lunarine, mechanism, enzyme needs to be in reduced state Trypanosoma cruzi
1.8.1.12 N-(3-dimethylamino-propyl)-O-[(E)-3-(3-[(E)-3-[N-(3-dimethylamino-propyl)aminooxy]-propenyl]-benzofuran-5-yl)-allyl]-hydroxylamine benzofuranyl-based acyclic bis-polyamine analogue of lunarine with a planar bicyclic benzofuranyl scaffold, inhibition mechanism Trypanosoma cruzi
1.8.1.12 N-[3-(4-amino-butylamino)-propyl]-O-[(E)-3-[3-((E)-3-[N-[3-(4-amino-butylamino)-propyl]aminooxy]-propenyl)-benzofuran-5-yl]-allyl]-hydroxylamine benzofuranyl-based acyclic bis-polyamine analogue of lunarine with a planar bicyclic benzofuranyl scaffold, inhibition mechanism Trypanosoma cruzi
1.8.1.12 N-[3-(4-methyl-piperazin-1-yl)-propyl]-O-[(E)-3-[3-((E)-3-[N-[3-(4-methyl-piperazin-1-yl)-propyl]aminooxy]-propenyl)-benzofuran-5-yl]-allyl]-hydroxylamine benzofuranyl-based acyclic bis-polyamine analogue of lunarine with a planar bicyclic benzofuranyl scaffold, inhibition mechanism Trypanosoma cruzi

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.1.12 additional information Trypanosoma cruzi enzyme is required for maintaining the reducing intracellular environment ?
-
 ?
1.8.1.12 trypanothione disulfide + NADPH Trypanosoma cruzi
-
 trypanothione + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.12 Trypanosoma cruzi
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.12 additional information enzyme is required for maintaining the reducing intracellular environment Trypanosoma cruzi ?
-
 ?
1.8.1.12 trypanothione disulfide + NADPH
-
 Trypanosoma cruzi trypanothione + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.12 trypanothione reductase
-
 Trypanosoma cruzi
1.8.1.12 TryR
-
 Trypanosoma cruzi

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.12 additional information enzyme is a flavoprotein Trypanosoma cruzi
1.8.1.12 NADPH dependent on Trypanosoma cruzi

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.8.1.12 additional information
-
 additional information inhibition kinetics Trypanosoma cruzi