EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.8.98.2 | peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH | Homo sapiens | antioxidant protein with a role in signaling through catalytic reduction of oxidative modifications. Srx also has a role in the reduction of glutathionylation a post-translational, oxidative modification that occurs on numerous proteins and has been implicated in a wide variety of pathologies, including Parkinsons disease. Unlike the reduction of peroxiredoxin overoxidation, Srx-dependent deglutathionylation appears to be nonspecific | peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R | - |
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EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.8.98.2 | Homo sapiens | - |
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EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.8.98.2 | peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH | antioxidant protein with a role in signaling through catalytic reduction of oxidative modifications. Srx also has a role in the reduction of glutathionylation a post-translational, oxidative modification that occurs on numerous proteins and has been implicated in a wide variety of pathologies, including Parkinsons disease. Unlike the reduction of peroxiredoxin overoxidation, Srx-dependent deglutathionylation appears to be nonspecific | Homo sapiens | peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R | - |
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