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Literature summary extracted from

  • Tsutsumi, H.; Katagi, M.; Nishikawa, M.; Tsuchihashi, H.; Kasuya, F.; Igarashi, K.
    In vitro confirmation of selegiline N-oxidation by flavin-containing monooxygenase in rat microsome using LC-ESI MS (2004), Biol. Pharm. Bull., 27, 1572-1575.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.13.8 n-octylamine 1 mM, 2fold stimulation Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.13.8 Methimazole
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.14.13.8 0.0713
-
 selegiline pH 8.0 Rattus norvegicus
1.14.13.8 0.1775
-
 selegiline pH 7.4 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.13.8 microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.13.8 selegiline + NADPH + O2 Rattus norvegicus
-
 selegiline N-oxide + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.13.8 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.13.8 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.13.8 selegiline + NADPH + O2
-
 Rattus norvegicus selegiline N-oxide + NADP+
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.14.13.8 8 8.5
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.13.8 NADPH
-
 Rattus norvegicus