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Literature summary extracted from

  • Schilling, S.; Manhart, S.; Hoffmann, T.; Ludwig, H.H.; Wasternack, C.; Demuth, H.U.
    Substrate specificity of glutaminyl cyclases from plants and animals (2003), Biol. Chem., 384, 1583-1592.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.2.5 Gln-tert-butyl ester
-
 Carica papaya
2.3.2.5 Gln-tert-butyl ester
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.2.5 0.023
-
 [Gln1]-neurotensin pH 8.0, 30°C Carica papaya
2.3.2.5 0.031
-
 [Gln1]-gastrin pH 8.0, 30°C Homo sapiens
2.3.2.5 0.032
-
 N1-naphthalen-2-yl-L-glutamamide pH 8.0, 30°C, 0.5 M KCl Carica papaya
2.3.2.5 0.033
-
 [Gln1]-gastrin pH 8.0, 30°C Carica papaya
2.3.2.5 0.034
-
 Gln-Lys-Arg-Leu-NH2 pH 8.0, 30°C, 0.5 M KCl Homo sapiens
2.3.2.5 0.037
-
 [Gln1]-neurotensin pH 8.0, 30°C Homo sapiens
2.3.2.5 0.038
-
 Gln-beta-naphthylamine pH 8.0, 30°C Carica papaya
2.3.2.5 0.039
-
 Gln-Glu-Ala-Phe-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 0.041
-
 Gln-Gln-Tyr-Phe-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 0.042
-
 Gln 7-amido-4-methylcoumarin pH 8.0, 30°C Carica papaya
2.3.2.5 0.044
-
 Gln-Gln pH 8.0, 30°C Carica papaya
2.3.2.5 0.045
-
 Gln-Gln-Tyr-Phe-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 0.047
-
 Gln-Glu-Tyr-Phe-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 0.05
-
 Gln-Trp-Ala-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 0.053
-
 [Gln1]-gonadotropin releasing-hormone pH 8.0, 30°C Homo sapiens
2.3.2.5 0.053
-
 Gln-Lys-Arg-Leu-NH2 pH 8.0, 30°C, 0.5 M KCl Carica papaya
2.3.2.5 0.054
-
 Gln-Lys-Arg-Leu-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 0.054
-
 [Gln1]-gonadotropin releasing-hormone pH 8.0, 30°C Carica papaya
2.3.2.5 0.054
-
 Gln-7-amido-4-methylcoumarin pH 8.0, 30°C Homo sapiens
2.3.2.5 0.055
-
 Gln-Glu-Asp-Leu-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 0.055
-
 Gln-Ser-Tyr-Phe-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 0.055
-
 Gln-Arg-Tyr-Phe-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 0.056
-
 Gln-Trp-Ala-NH2 pH 8.0, 30°C, 0.5 M KCl Homo sapiens
2.3.2.5 0.061
-
 Gln-Glu-Asp-Leu-NH2 pH 8.0, 30°C, 0.5 M KCl Homo sapiens
2.3.2.5 0.063
-
 Gln-Tyr-Ala pH 8.0, 30°C Carica papaya
2.3.2.5 0.063
-
 N1-naphthalen-2-yl-L-glutamamide pH 8.0, 30°C, 0.5 M KCl Homo sapiens
2.3.2.5 0.065
-
 Gln-Ala-Ala-Ala-Ala-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 0.065
-
 Gln-Arg-Gly-Ile-NH2 pH 8.0, 30°C, 0.5 M KCl Carica papaya
2.3.2.5 0.068
-
 Gln-His-Tyr-Phe-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 0.069
-
 Gln-Phe-Ala-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 0.069
-
 Gln-Glu-Tyr-Ala-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 0.07
-
 Gln-beta-naphthylamide pH 8.0, 30°C Homo sapiens
2.3.2.5 0.072
-
 Gln-Trp-Ala-NH2 pH 8.0, 30°C, 0.5 M KCl Carica papaya
2.3.2.5 0.077
-
 Gln-Glu-Ala-Ala-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 0.078
-
 Gln-Trp-Ala-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 0.079
-
 Gln-Glu-Tyr-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 0.079
-
 Gln-Ala-Ala-Ser-Ala-Ala-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 0.081
-
 Gln-Glu-Ala-Phe-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 0.087
-
 [Gln1]-fertilization promoting peptide pH 8.0, 30°C Homo sapiens
2.3.2.5 0.087
-
 Gln-Ala-Ala-NH2 pH 8.0, 30°Cl Homo sapiens
2.3.2.5 0.09
-
 [Gln1]-thyrotropin releasing-hormone pH 8.0, 30°C Homo sapiens
2.3.2.5 0.091
-
 Gln-Arg-Gly-Ile-NH2 pH 8.0, 30°C, 0.5 M KCl Homo sapiens
2.3.2.5 0.092
-
 Gln-His-Tyr-Phe-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 0.094
-
 Gln-Glu pH 8.0, 30°C, 0.5 M KCl Carica papaya
2.3.2.5 0.094
-
 Gln-Glu-Asp-Leu-NH2 pH 8.0, 30°C, 0.5 M KCl Carica papaya
2.3.2.5 0.1
-
 Gln-Glu-Tyr-Phe-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 0.101
-
 Gln-Tyr-Ala pH 8.0, 30°C Homo sapiens
2.3.2.5 0.102
-
 Gln-Glu-Ala-Ala-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 0.103
-
 Gln-Glu-Tyr-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 0.106
-
 Gln-Glu pH 8.0, 30°C Carica papaya
2.3.2.5 0.107
-
 Gln-Glu-Asp-Leu-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 0.111
-
 Gln-Phe-Ala-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 0.113
-
 Gln-Glu-Tyr-Ala-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 0.118
-
 Gln-Lys-Arg-Leu-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 0.123
-
 Gln-Arg-Gly-Ile-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 0.124
-
 Gln-Arg-Tyr-Phe-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 0.13
-
 Gln-Gly-Pro pH 8.0, 30°C Homo sapiens
2.3.2.5 0.135
-
 Gln-Ser-Tyr-Phe-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 0.143
-
 Gln-Arg-Gly-Ile-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 0.143
-
 Gln-Ala pH 8.0, 30°C, 0.5 M KCl Carica papaya
2.3.2.5 0.148
-
 Gln-Gln pH 8.0, 30°C Homo sapiens
2.3.2.5 0.149
-
 Gln-Pro-Tyr-Phe-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 0.151
-
 [Gln1]-fertilization promoting peptide pH 8.0, 30°C Carica papaya
2.3.2.5 0.153
-
 Gln-Asn-Gly-Ile-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 0.158
-
 Gln-Ala pH 8.0, 30°C Carica papaya
2.3.2.5 0.164
-
 Gln-Ala-Ala-NH2 pH 8.0, 30°Cl Carica papaya
2.3.2.5 0.172
-
 Gln-Asn-Gly-Ile-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 0.196
-
 Gln-Val pH 8.0, 30°C Homo sapiens
2.3.2.5 0.197
-
 Gln-Ala-Ala-Ala-Ala-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 0.211
-
 Gln-Tyr pH 8.0, 30°C Homo sapiens
2.3.2.5 0.216
-
 Gln-Ala-Ala-Ser-Ala-Ala-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 0.223
-
 Gln-tert-butyl ester pH 8.0, 30°C Carica papaya
2.3.2.5 0.232
-
 Gln-Ala pH 8.0, 30°C Homo sapiens
2.3.2.5 0.247
-
 Gln-Gly pH 8.0, 30°C Homo sapiens
2.3.2.5 0.333
-
 Gln-Gly-Pro pH 8.0, 30°C Carica papaya
2.3.2.5 0.357
-
 Gln-Ala pH 8.0, 30°C, 0.5 M KCl Homo sapiens
2.3.2.5 0.359
-
 Gln-Glu pH 8.0, 30°C Homo sapiens
2.3.2.5 0.401
-
 Gln-NH2 pH 8.0, 30°C, 0.5 M KCl Homo sapiens
2.3.2.5 0.409
-
 Gln-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 0.433
-
 Gln-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 0.446
-
 Gln-NH2 pH 8.0, 30°C, 0.5 M KCl Carica papaya
2.3.2.5 0.607
-
 Gln-Glu pH 8.0, 30°C, 0.5 M KCl Homo sapiens
2.3.2.5 0.641
-
 Gln-Gly pH 8.0, 30°C Carica papaya
2.3.2.5 1.235
-
 Gln-tert-butyl ester pH 8.0, 30°C Homo sapiens
2.3.2.5 18.89
-
 Gln-Pro-Tyr-Phe-NH2 pH 8.0, 30°C Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.2.5 additional information substrate specificity for substrates with uncharged backbone and for Gln-Ala and Gln-Glu, does not change significantly by salt addition. With the positively charged substrates Gln-Arg-Gly-Ile-NH2 and Gln-Lys-Arg-Leu-NH2 addition of salt reveals a positive effect on catalysis Carica papaya
2.3.2.5 additional information substrate specificity for substrates with uncharged backbone does not change significantly by salt addition. For substrates such as Gln-Ala and Gln-Glu, addition of KCl decreases specificity. With the positively charged substrates Gln-Arg-Gly-Ile-NH2 and Gln-Lys-Arg-Leu-NH2 addition of salt reveals a positive effect on catalysis Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.2.5 additional information Homo sapiens the enzyme may play a key role in posttranslational modification ?
-
 ?
2.3.2.5 additional information Carica papaya the enzyme may play a key role in posttranslational modification ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.5 Carica papaya
-
-
-
2.3.2.5 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.5 Gln-7-amido-4-methylcoumarin
-
 Homo sapiens L-pyroglutamyl-4-methylcoumarin-7-amide + NH3
-
 ?
2.3.2.5 Gln-7-amido-4-methylcoumarin
-
 Carica papaya pyroglutamic acid-7-amido-4-methylcoumarin + NH3
-
 ?
2.3.2.5 Gln-Ala
-
 Homo sapiens pyroglutamic acid-Ala + NH3
-
 ?
2.3.2.5 Gln-Ala
-
 Carica papaya pyroglutamic acid-Ala + NH3
-
 ?
2.3.2.5 Gln-Ala-Ala-Ala-Ala-NH2
-
 Homo sapiens pyroglutamic acid-Ala-Ala-Ala-Ala-NH2 + NH3
-
 ?
2.3.2.5 Gln-Ala-Ala-Ala-Ala-NH2
-
 Carica papaya pyroglutamic acid-Ala-Ala-Ala-Ala-NH2 + NH3
-
 ?
2.3.2.5 Gln-Ala-Ala-NH2
-
 Homo sapiens pyroglutamic acid-Ala-Ala-NH2 + NH3
-
 ?
2.3.2.5 Gln-Ala-Ala-NH2
-
 Carica papaya pyroglutamic acid-Ala-Ala-NH2 + NH3
-
 ?
2.3.2.5 Gln-Ala-Ala-Ser-Ala-Ala-NH2
-
 Homo sapiens pyroglutamic acid-Ala-Ala-Ser-Ala-Ala-NH2 + NH3
-
 ?
2.3.2.5 Gln-Ala-Ala-Ser-Ala-Ala-NH2
-
 Carica papaya pyroglutamic acid-Ala-Ala-Ser-Ala-Ala-NH2 + NH3
-
 ?
2.3.2.5 Gln-Arg-Gly-Ile-NH2
-
 Homo sapiens pyroglutamic acid-Arg-Gly-Ile-NH2 + NH3
-
 ?
2.3.2.5 Gln-Arg-Gly-Ile-NH2
-
 Carica papaya pyroglutamic acid-Arg-Gly-Ile-NH2 + NH3
-
 ?
2.3.2.5 Gln-Arg-Tyr-Phe-NH2
-
 Homo sapiens pyroglutamic acid-Arg-Tyr-Phe-NH2 + NH3
-
 ?
2.3.2.5 Gln-Arg-Tyr-Phe-NH2
-
 Carica papaya pyroglutamic acid-Arg-Tyr-Phe-NH2 + NH3
-
 ?
2.3.2.5 Gln-Asn-Gly-Ile-NH2
-
 Homo sapiens pyroglutamic acid-Asn-Gly-Ile-NH2 + NH3
-
 ?
2.3.2.5 Gln-Asn-Gly-Ile-NH2
-
 Carica papaya pyroglutamic acid-Asn-Gly-Ile-NH2 + NH3
-
 ?
2.3.2.5 Gln-beta-naphthylamide
-
 Homo sapiens pyroglutamic acid-beta-naphthylamide + NH3
-
 ?
2.3.2.5 Gln-beta-naphthylamide
-
 Carica papaya pyroglutamic acid-beta-naphthylamine + NH3
-
 ?
2.3.2.5 Gln-Gln
-
 Homo sapiens pyroglutamic acid-Gln + NH3
-
 ?
2.3.2.5 Gln-Gln
-
 Carica papaya pyroglutamic acid-Gln + NH3
-
 ?
2.3.2.5 Gln-Gln-Tyr-Phe-NH2
-
 Homo sapiens pyroglutamic acid-Gln-Tyr-Phe-NH2 + NH3
-
 ?
2.3.2.5 Gln-Gln-Tyr-Phe-NH2
-
 Carica papaya pyroglutamic acid-Gln-Tyr-Phe-NH2 + NH3
-
 ?
2.3.2.5 Gln-Glu
-
 Homo sapiens pyroglutamic acid-Glu + NH3
-
 ?
2.3.2.5 Gln-Glu
-
 Carica papaya pyroglutamic acid-Glu + NH3
-
 ?
2.3.2.5 Gln-Glu-Ala-Ala-NH2
-
 Homo sapiens pyroglutamic acid-Glu-Ala-Ala-NH2 + NH3
-
 ?
2.3.2.5 Gln-Glu-Ala-Ala-NH2
-
 Carica papaya pyroglutamic acid-Glu-Ala-Ala-NH2 + NH3
-
 ?
2.3.2.5 Gln-Glu-Ala-Phe-NH2
-
 Homo sapiens pyroglutamic acid-Glu-Ala-Phe-NH2 + NH3
-
 ?
2.3.2.5 Gln-Glu-Ala-Phe-NH2
-
 Carica papaya pyroglutamic acid-Glu-Ala-Phe-NH2 + NH3
-
 ?
2.3.2.5 Gln-Glu-Asp-Leu-NH2
-
 Homo sapiens pyroglutamic acid-Glu-Asp-Leu-NH2 + NH3
-
 ?
2.3.2.5 Gln-Glu-Asp-Leu-NH2
-
 Carica papaya pyroglutamic acid-Glu-Asp-Leu-NH2 + NH3
-
 ?
2.3.2.5 Gln-Glu-Tyr-Ala-NH2
-
 Homo sapiens pyroglutamic acid-Glu-Tyr-Ala-NH2 + NH3
-
 ?
2.3.2.5 Gln-Glu-Tyr-Ala-NH2
-
 Carica papaya pyroglutamic acid-Glu-Tyr-Ala-NH2 + NH3
-
 ?
2.3.2.5 Gln-Glu-Tyr-NH2
-
 Homo sapiens pyroglutamic acid-Glu-Tyr-NH2 + NH3
-
 ?
2.3.2.5 Gln-Glu-Tyr-NH2
-
 Carica papaya pyroglutamic acid-Glu-Tyr-NH2 + NH3
-
 ?
2.3.2.5 Gln-Glu-Tyr-Phe-NH2
-
 Homo sapiens pyroglutamic acid-Glu-Tyr-Phe-NH2 + NH3
-
 ?
2.3.2.5 Gln-Glu-Tyr-Phe-NH2
-
 Carica papaya pyroglutamic acid-Glu-Tyr-Phe-NH2 + NH3
-
 ?
2.3.2.5 Gln-Gly
-
 Homo sapiens pyroglutamic acid-Gly + NH3
-
 ?
2.3.2.5 Gln-Gly
-
 Carica papaya pyroglutamic acid-Gly + NH3
-
 ?
2.3.2.5 Gln-Gly-Pro
-
 Homo sapiens pyroglutamic acid-Gly-Pro + NH3
-
 ?
2.3.2.5 Gln-Gly-Pro
-
 Carica papaya pyroglutamic acid-Gly-Pro + NH3
-
 ?
2.3.2.5 Gln-His-Tyr-Phe-NH2
-
 Homo sapiens pyroglutamic acid-His-Tyr-Phe-NH2 + NH3
-
 ?
2.3.2.5 Gln-His-Tyr-Phe-NH2
-
 Carica papaya pyroglutamic acid-His-Tyr-Phe-NH2 + NH3
-
 ?
2.3.2.5 Gln-Lys-Arg-Leu-NH2
-
 Homo sapiens pyroglutamic acid-Lys-Arg-Leu-NH2 + NH3
-
 ?
2.3.2.5 Gln-Lys-Arg-Leu-NH2
-
 Carica papaya pyroglutamic acid-Lys-Arg-Leu-NH2 + NH3
-
 ?
2.3.2.5 Gln-Phe-Ala-NH2
-
 Homo sapiens pyroglutamic acid-Phe-Ala-NH2 + NH3
-
 ?
2.3.2.5 Gln-Phe-Ala-NH2
-
 Carica papaya pyroglutamic acid-Phe-Ala-NH2 + NH3
-
 ?
2.3.2.5 Gln-Pro-Tyr-Phe-NH2
-
 Homo sapiens pyroglutamic acid-Pro-Tyr-Phe-NH2 + NH3
-
 ?
2.3.2.5 Gln-Pro-Tyr-Phe-NH2
-
 Carica papaya pyroglutamic acid-Pro-Tyr-Phe-NH2 + NH3
-
 ?
2.3.2.5 Gln-Ser-Tyr-Phe-NH2
-
 Homo sapiens pyroglutamic acid-Ser-Tyr-Phe-NH2 + NH3
-
 ?
2.3.2.5 Gln-Ser-Tyr-Phe-NH2
-
 Carica papaya pyroglutamic acid-Ser-Tyr-Phe-NH2 + NH3
-
 ?
2.3.2.5 Gln-tert-butyl ester
-
 Homo sapiens pyroglutamyl-tert-butyl ester + NH3
-
 ?
2.3.2.5 Gln-tert-butyl ester
-
 Carica papaya pyroglutamyl-tert-butyl ester + NH3
-
 ?
2.3.2.5 Gln-Trp-Ala-NH2
-
 Homo sapiens pyroglutamic acid-Trp-Ala-NH2 + NH3
-
 ?
2.3.2.5 Gln-Trp-Ala-NH2
-
 Carica papaya pyroglutamic acid-Trp-Ala-NH2 + NH3
-
 ?
2.3.2.5 Gln-Tyr
-
 Homo sapiens pyroglutamic acid-Tyr + NH3
-
 ?
2.3.2.5 Gln-Tyr-Ala
-
 Homo sapiens pyroglutamic acid-Tyr-Ala + NH3
-
 ?
2.3.2.5 Gln-Tyr-Ala
-
 Carica papaya pyroglutamic acid-Tyr-Ala + NH3
-
 ?
2.3.2.5 Gln-Val
-
 Homo sapiens pyroglutamic acid-Val + NH3
-
 ?
2.3.2.5 L-Gln-NH2
-
 Homo sapiens L-pyroglutamyl amide + NH3
-
 ?
2.3.2.5 L-Gln-NH2
-
 Carica papaya L-pyroglutamyl amide + NH3
-
 ?
2.3.2.5 additional information the enzyme may play a key role in posttranslational modification Homo sapiens ?
-
 ?
2.3.2.5 additional information the enzyme may play a key role in posttranslational modification Carica papaya ?
-
 ?
2.3.2.5 [Gln1]-fertilization promoting peptide
-
 Homo sapiens [pyroglutamyl]-fertilization promoting peptide + NH3
-
 ?
2.3.2.5 [Gln1]-fertilization promoting peptide
-
 Carica papaya [pyroglutamyl]-fertilization promoting peptide + NH3
-
 ?
2.3.2.5 [Gln1]-gastrin
-
 Homo sapiens [pyroglutamyl]-gastrin + NH3
-
 ?
2.3.2.5 [Gln1]-gastrin
-
 Carica papaya [pyroglutamyl]-gastrin + NH3
-
 ?
2.3.2.5 [Gln1]-gonadotropin releasing-hormone
-
 Homo sapiens [pyroglutamyl]-gonadotropin releasing-hormone + NH3
-
 ?
2.3.2.5 [Gln1]-gonadotropin releasing-hormone
-
 Carica papaya [pyroglutamyl]-gonadotropin releasing-hormone + NH3
-
 ?
2.3.2.5 [Gln1]-neurotensin
-
 Homo sapiens [pyroglutamyl]-neurotensin + NH3
-
 ?
2.3.2.5 [Gln1]-neurotensin
-
 Carica papaya [pyroglutamyl]-neurotensin + NH3
-
 ?
2.3.2.5 [Gln1]-thyrotropin releasing-hormone
-
 Homo sapiens [pyroglutamyl]-thyrotropin releasing-hormone + NH3
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.3.2.5 5.3
-
 Gln-7-amido-4-methylcoumarin pH 8.0, 30°C Homo sapiens
2.3.2.5 6.7
-
 Gln-tert-butyl ester pH 8.0, 30°C Homo sapiens
2.3.2.5 12.2
-
 Gln-NH2 pH 8.0, 30°C, 0.5 M KCl Homo sapiens
2.3.2.5 12.8
-
 Gln-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 13.2
-
 Gln-Gly pH 8.0, 30°C Homo sapiens
2.3.2.5 17.2
-
 Gln-Val pH 8.0, 30°C Homo sapiens
2.3.2.5 18.8
-
 Gln-Pro-Tyr-Phe-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 18.9
-
 Gln-Glu pH 8.0, 30°C, 0.5 M KCl Homo sapiens
2.3.2.5 20
-
 N1-naphthalen-2-yl-L-glutamamide pH 8.0, 30°C, 0.5 M KCl Homo sapiens
2.3.2.5 20.6
-
 Gln-beta-naphthylamide pH 8.0, 30°C Homo sapiens
2.3.2.5 20.7
-
 Gln-Gln pH 8.0, 30°C Homo sapiens
2.3.2.5 24.7
-
 Gln-Glu pH 8.0, 30°C Homo sapiens
2.3.2.5 25.3
-
 Gln-Gly-Pro pH 8.0, 30°C Homo sapiens
2.3.2.5 29.6
-
 Gln-Arg-Tyr-Phe-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 29.8
-
 Gln-Arg-Gly-Ile-NH2 pH 8.0, 30°C, 0.5 M KCl Homo sapiens
2.3.2.5 31.6
-
 [Gln1]-gastrin pH 8.0, 30°C Carica papaya
2.3.2.5 31.6
-
 Gln-Lys-Arg-Leu-NH2 pH 8.0, 30°C, 0.5 M KCl Homo sapiens
2.3.2.5 31.7
-
 Gln-Pro-Tyr-Phe-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 33.4
-
 Gln-Lys-Arg-Leu-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 33.5
-
 Gln-Arg-Gly-Ile-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 37.7
-
 [Gln1]-neurotensin pH 8.0, 30°C Carica papaya
2.3.2.5 37.7
-
 [Gln1]-fertilization promoting peptide pH 8.0, 30°C Carica papaya
2.3.2.5 39
-
 Gln-Glu-Ala-Phe-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 39.4
-
 Gln 7-amido-4-methylcoumarin pH 8.0, 30°C Carica papaya
2.3.2.5 41.4
-
 Gln-Gln-Tyr-Phe-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 41.7
-
 Gln-Gly-Pro pH 8.0, 30°C Carica papaya
2.3.2.5 42.1
-
 Gln-Glu-Tyr-Ala-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 43.2
-
 Gln-Gln pH 8.0, 30°C Carica papaya
2.3.2.5 44.4
-
 Gln-Glu pH 8.0, 30°C, 0.5 M KCl Carica papaya
2.3.2.5 44.7
-
 Gln-Glu-Tyr-Ala-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 44.8
-
 Gln-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 45.1
-
 Gln-Glu-Tyr-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 45.2
-
 Gln-NH2 pH 8.0, 30°C, 0.5 M KCl Carica papaya
2.3.2.5 45.6
-
 Gln-Glu-Asp-Leu-NH2 pH 8.0, 30°C, 0.5 M KCl Homo sapiens
2.3.2.5 45.8
-
 Gln-Gly pH 8.0, 30°C Carica papaya
2.3.2.5 45.8
-
 Gln-Glu-Asp-Leu-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 46
-
 Gln-Glu-Tyr-Phe-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 46
-
 Gln-Glu-Ala-Ala-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 47
-
 Gln-Trp-Ala-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 47.2
-
 N1-naphthalen-2-yl-L-glutamamide pH 8.0, 30°C, 0.5 M KCl Carica papaya
2.3.2.5 47.6
-
 Gln-Ala pH 8.0, 30°C, 0.5 M KCl Homo sapiens
2.3.2.5 48.2
-
 Gln-Lys-Arg-Leu-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 48.4
-
 Gln-Arg-Gly-Ile-NH2 pH 8.0, 30°C, 0.5 M KCl Carica papaya
2.3.2.5 48.5
-
 Gln-Glu-Ala-Phe-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 48.8
-
 [Gln1]-neurotensin pH 8.0, 30°C Homo sapiens
2.3.2.5 48.9
-
 Gln-Arg-Tyr-Phe-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 49.2
-
 Gln-Arg-Gly-Ile-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 49.4
-
 Gln-tert-butyl ester pH 8.0, 30°C Carica papaya
2.3.2.5 50
-
 Gln-Trp-Ala-NH2 pH 8.0, 30°C, 0.5 M KCl Homo sapiens
2.3.2.5 50.3
-
 Gln-Glu pH 8.0, 30°C Carica papaya
2.3.2.5 51.4
-
 Gln-Asn-Gly-Ile-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 51.4
-
 Gln-beta-naphthylamine pH 8.0, 30°C Carica papaya
2.3.2.5 52.8
-
 Gln-Ser-Tyr-Phe-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 52.9
-
 Gln-Gln-Tyr-Phe-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 53.6
-
 Gln-Glu-Tyr-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 53.6
-
 Gln-Glu-Asp-Leu-NH2 pH 8.0, 30°C, 0.5 M KCl Carica papaya
2.3.2.5 53.7
-
 Gln-Glu-Ala-Ala-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 54.1
-
 [Gln1]-gastrin pH 8.0, 30°C Homo sapiens
2.3.2.5 54.6
-
 Gln-Glu-Tyr-Phe-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 55.3
-
 Gln-Ala-Ala-Ser-Ala-Ala-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 55.4
-
 Gln-His-Tyr-Phe-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 56.6
-
 Gln-Asn-Gly-Ile-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 57.2
-
 Gln-Ala pH 8.0, 30°C Homo sapiens
2.3.2.5 58.1
-
 Gln-Lys-Arg-Leu-NH2 pH 8.0, 30°C, 0.5 M KCl Carica papaya
2.3.2.5 58.5
-
 Gln-Glu-Asp-Leu-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 60.5
-
 Gln-Ala-Ala-Ala-Ala-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 64.9
-
 Gln-Ser-Tyr-Phe-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 68.1
-
 Gln-Ala pH 8.0, 30°C, 0.5 M KCl Carica papaya
2.3.2.5 69.2
-
 [Gln1]-gonadotropin releasing-hormone pH 8.0, 30°C Homo sapiens
2.3.2.5 69.6
-
 [Gln1]-fertilization promoting peptide pH 8.0, 30°C Homo sapiens
2.3.2.5 69.8
-
 Gln-Ala pH 8.0, 30°C Carica papaya
2.3.2.5 72.4
-
 [Gln1]-gonadotropin releasing-hormone pH 8.0, 30°C Carica papaya
2.3.2.5 74.6
-
 Gln-Ala-Ala-Ala-Ala-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 75.9
-
 Gln-His-Tyr-Phe-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 76.3
-
 Gln-Ala-Ala-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 78.5
-
 Gln-Ala-Ala-Ser-Ala-Ala-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 82.8
-
 [Gln1]-thyrotropin releasing-hormone pH 8.0, 30°C Homo sapiens
2.3.2.5 83.2
-
 Gln-Ala-Ala-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 94
-
 Gln-Tyr pH 8.0, 30°C Homo sapiens
2.3.2.5 104
-
 Gln-Tyr-Ala pH 8.0, 30°C Carica papaya
2.3.2.5 109
-
 Gln-Phe-Ala-NH2 pH 8.0, 30°C Homo sapiens
2.3.2.5 125
-
 Gln-Tyr-Ala pH 8.0, 30°C Homo sapiens
2.3.2.5 132
-
 Gln-Phe-Ala-NH2 pH 8.0, 30°C Carica papaya
2.3.2.5 133
-
 Gln-Trp-Ala-NH2 pH 8.0, 30°C, 0.5 M KCl Carica papaya
2.3.2.5 151.8
-
 Gln-Trp-Ala-NH2 pH 8.0, 30°C Carica papaya

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.2.5 7.8 8
-
 Homo sapiens
2.3.2.5 7.8 8
-
 Carica papaya

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
2.3.2.5 4
-
 30°C, 30 min, about 10% loss of activity Carica papaya
2.3.2.5 5 6 30°C, 30 min, about 30% loss of activity Carica papaya
2.3.2.5 5.5
-
 30°C, 30 min, about 70% loss of activity Homo sapiens
2.3.2.5 6
-
 30°C, 30 min, about 50% loss of activity Homo sapiens
2.3.2.5 6.5
-
 30°C, 30 min, about 40% loss of activity Homo sapiens
2.3.2.5 6.5 8 30°C, 30 min, about 10% loss of activity Carica papaya
2.3.2.5 7 9 30°C, 30 min, less than 20% loss of activity Homo sapiens
2.3.2.5 8.5
-
 30°C, 30 min, about 20% loss of activity Carica papaya
2.3.2.5 9 10 30°C, 30 min, about 15% loss of activity Carica papaya
2.3.2.5 9.5
-
 30°C, 30 min, about 50% loss of activity Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.3.2.5 0.97
-
 Gln-tert-butyl ester pH 8.0, 30°C, 0.5 M KCl Homo sapiens
2.3.2.5 1.2
-
 Gln-tert-butyl ester pH 8.0, 30°C Carica papaya
2.3.2.5 1.21
-
 Gln-tert-butyl ester pH 8.0, 30°C Homo sapiens
2.3.2.5 1.33
-
 Gln-tert-butyl ester pH 8.0, 30°C, 0.5 M KCl Carica papaya