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Literature summary extracted from

  • Neville, N.T.; Parton, J.; Harwood, J.L.; Jackson, S.K.
    The activities of monocyte lysophosphatidylcholine acyltransferase and coenzyme A-independent transacylase are changed by the inflammatory cytokines tumor necrosis factor alpha and interferon gamma (2005), Biochim. Biophys. Acta, 1733, 232-238.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.147 interferon gamma i.e. IFN-gamma, human, recombinant, increases enzyme activity in microsomes by about 100% Homo sapiens
2.3.1.147 Tumor necrosis factor alpha i.e. TNF-alpha, human, recombinant, 50% increase in enzyme activity within 30 min incubation of microsomes Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.147 microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.23 additional information Homo sapiens priming of Mono-Mac 6 cells by IFNgamma appears to involve LPCAT ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.23 Homo sapiens
-
-
-
2.3.1.147 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.23 Mono-Mac-6 cell priming of Mono-Mac-6 cells by IFNgamma appears to involve LPCAT Homo sapiens
-
2.3.1.23 monocyte
-
 Homo sapiens
-
2.3.1.147 MM6 cell i.e. mono-mac 6, monocytic cell line Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.23 additional information priming of Mono-Mac 6 cells by IFNgamma appears to involve LPCAT Homo sapiens ?
-
 ?
2.3.1.147 1-alkyl-2-lyso-glyceryl phosphorylcholine + oleoyl-CoA
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.23 LPCAT
-
 Homo sapiens
2.3.1.147 CoAIT
-
 Homo sapiens
2.3.1.147 Coenzyme A-independent transacylase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.147 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.147 7.4
-
 assay at Homo sapiens