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Literature summary extracted from
- Protein maintenance in aging and replicative senescence: a role for the peptide methionine sulfoxide reductases (2005), Biochim. Biophys. Acta, 1703, 261-266.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.8.4.11 | mitochondrial and cytosolic isozymes are encoded on a single gene with 2 initiations sites, delivering an N-terminal signal peptide to the mitochondrial enzyme form | Rattus norvegicus |
| 1.8.4.12 | mitochondrial and cytosolic isozymes are encoded on a single gene with 2 initiations sites, delivering an N-terminal signal peptide to the mitochondrial enzyme form | Rattus norvegicus |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 1.8.4.11 | additional information | overexpression of MsrA leads to extended life span of the flies up to 70%, the resistance against paraquat-induced oxidative stress is increased | Drosophila melanogaster |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.8.4.11 | cytosol | - |
Rattus norvegicus | 5829 | - |
| 1.8.4.11 | mitochondrion | matrix | Rattus norvegicus | 5739 | - |
| 1.8.4.12 | cytosol | - |
Rattus norvegicus | 5829 | - |
| 1.8.4.12 | mitochondrion | matrix | Rattus norvegicus | 5739 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | Drosophila melanogaster | MsrA is specific for the S-form | L-methionine + thioredoxin disulfide + H2O | - |
? |  |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | Escherichia coli | MsrA is specific for the S-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | Homo sapiens | MsrA is specific for the S-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | Rattus norvegicus | MsrA is specific for the S-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | Saccharomyces cerevisiae | MsrA is specific for the S-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.11 | additional information | Escherichia coli | cellular system of balancing native proteins and oxidatively damaged proteins by use of protein biosynthesis, protein oxidative modification, protein elimination, and oxidized protein repair involving the enzyme, overview, enzyme protects against oxidative damage of proteins | ? | - |
? | |
| 1.8.4.11 | additional information | Saccharomyces cerevisiae | cellular system of balancing native proteins and oxidatively damaged proteins by use of protein biosynthesis, protein oxidative modification, protein elimination, and oxidized protein repair involving the enzyme, overview, enzyme protects against oxidative damage of proteins, enzyme activity is not age-related | ? | - |
? | |
| 1.8.4.11 | additional information | Drosophila melanogaster | cellular system of balancing native proteins and oxidatively damaged proteins by use of protein biosynthesis, protein oxidative modification, protein elimination, and oxidized protein repair involving the enzyme, overview, enzyme protects against oxidative damage of proteins, loss of enzyme activity is age-related | ? | - |
? | |
| 1.8.4.11 | additional information | Homo sapiens | cellular system of balancing native proteins and oxidatively damaged proteins by use of protein biosynthesis, protein oxidative modification, protein elimination, and oxidized protein repair involving the enzyme, overview, enzyme protects against oxidative damage of proteins, loss of enzyme activity is age-related | ? | - |
? | |
| 1.8.4.11 | additional information | Rattus norvegicus | cellular system of balancing native proteins and oxidatively damaged proteins by use of protein biosynthesis, protein oxidative modification, protein elimination, and oxidized protein repair involving the enzyme, overview, enzyme protects against oxidative damage of proteins, loss of enzyme activity is age-related | ? | - |
? | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin | Drosophila melanogaster | MsrB is specific for the R-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin | Escherichia coli | MsrB is specific for the R-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin | Homo sapiens | MsrB is specific for the R-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin | Rattus norvegicus | MsrB is specific for the R-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin | Saccharomyces cerevisiae | MsrB is specific for the R-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | additional information | Escherichia coli | cellular system of balancing native proteins and oxidatively damaged proteins by use of protein biosynthesis, protein oxidative modification, protein elimination, and oxidized protein repair involving the enzyme, overview, enzyme protects against oxidative damage of proteins | ? | - |
? | |
| 1.8.4.12 | additional information | Saccharomyces cerevisiae | cellular system of balancing native proteins and oxidatively damaged proteins by use of protein biosynthesis, protein oxidative modification, protein elimination, and oxidized protein repair involving the enzyme, overview, enzyme protects against oxidative damage of proteins, enzyme activity is not age-related | ? | - |
? | |
| 1.8.4.12 | additional information | Drosophila melanogaster | cellular system of balancing native proteins and oxidatively damaged proteins by use of protein biosynthesis, protein oxidative modification, protein elimination, and oxidized protein repair involving the enzyme, overview, enzyme protects against oxidative damage of proteins, loss of enzyme activity is age-related | ? | - |
? | |
| 1.8.4.12 | additional information | Homo sapiens | cellular system of balancing native proteins and oxidatively damaged proteins by use of protein biosynthesis, protein oxidative modification, protein elimination, and oxidized protein repair involving the enzyme, overview, enzyme protects against oxidative damage of proteins, loss of enzyme activity is age-related | ? | - |
? | |
| 1.8.4.12 | additional information | Rattus norvegicus | cellular system of balancing native proteins and oxidatively damaged proteins by use of protein biosynthesis, protein oxidative modification, protein elimination, and oxidized protein repair involving the enzyme, overview, enzyme protects against oxidative damage of proteins, loss of enzyme activity is age-related | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.4.11 | Drosophila melanogaster | - |
- |
- |
| 1.8.4.11 | Escherichia coli | - |
- |
- |
| 1.8.4.11 | Homo sapiens | - |
- |
- |
| 1.8.4.11 | Rattus norvegicus | - |
- |
- |
| 1.8.4.11 | Saccharomyces cerevisiae | - |
- |
- |
| 1.8.4.12 | Drosophila melanogaster | - |
- |
- |
| 1.8.4.12 | Escherichia coli | - |
- |
- |
| 1.8.4.12 | Homo sapiens | - |
- |
- |
| 1.8.4.12 | Rattus norvegicus | - |
- |
- |
| 1.8.4.12 | Saccharomyces cerevisiae | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.8.4.11 | brain | MsrA | Rattus norvegicus | - |
| 1.8.4.11 | fibroblast | cell line WI-38, young and old cells, enzyme expression pattern during cell development, senescent cells show decreased enzyme expression and activity | Homo sapiens | - |
| 1.8.4.11 | kidney | MsrA | Rattus norvegicus | - |
| 1.8.4.11 | liver | MsrA | Rattus norvegicus | - |
| 1.8.4.11 | additional information | organ-specific expression patterns | Rattus norvegicus | - |
| 1.8.4.11 | WI-38 cell | fibroblast, young and old cells, enzyme expression pattern during cell development | Homo sapiens | - |
| 1.8.4.12 | fibroblast | cell line WI-38, young and old cells, enzyme expression pattern during cell development, senescent cells show decreased enzyme expression and activity | Homo sapiens | - |
| 1.8.4.12 | WI-38 cell | fibroblast, young and old cells, enzyme expression pattern during cell development | Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | MsrA is specific for the S-form | Drosophila melanogaster | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | MsrA is specific for the S-form | Escherichia coli | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | MsrA is specific for the S-form | Homo sapiens | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | MsrA is specific for the S-form | Rattus norvegicus | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | MsrA is specific for the S-form | Saccharomyces cerevisiae | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.11 | additional information | cellular system of balancing native proteins and oxidatively damaged proteins by use of protein biosynthesis, protein oxidative modification, protein elimination, and oxidized protein repair involving the enzyme, overview, enzyme protects against oxidative damage of proteins | Escherichia coli | ? | - |
? | |
| 1.8.4.11 | additional information | cellular system of balancing native proteins and oxidatively damaged proteins by use of protein biosynthesis, protein oxidative modification, protein elimination, and oxidized protein repair involving the enzyme, overview, enzyme protects against oxidative damage of proteins, enzyme activity is not age-related | Saccharomyces cerevisiae | ? | - |
? | |
| 1.8.4.11 | additional information | cellular system of balancing native proteins and oxidatively damaged proteins by use of protein biosynthesis, protein oxidative modification, protein elimination, and oxidized protein repair involving the enzyme, overview, enzyme protects against oxidative damage of proteins, loss of enzyme activity is age-related | Drosophila melanogaster | ? | - |
? | |
| 1.8.4.11 | additional information | cellular system of balancing native proteins and oxidatively damaged proteins by use of protein biosynthesis, protein oxidative modification, protein elimination, and oxidized protein repair involving the enzyme, overview, enzyme protects against oxidative damage of proteins, loss of enzyme activity is age-related | Homo sapiens | ? | - |
? | |
| 1.8.4.11 | additional information | cellular system of balancing native proteins and oxidatively damaged proteins by use of protein biosynthesis, protein oxidative modification, protein elimination, and oxidized protein repair involving the enzyme, overview, enzyme protects against oxidative damage of proteins, loss of enzyme activity is age-related | Rattus norvegicus | ? | - |
? | |
| 1.8.4.11 | N-acetyl-L-methionine (S)-sulfoxide + thioredoxin | MsrA is specific for the S-form | Saccharomyces cerevisiae | N-acetyl-L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form | Drosophila melanogaster | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form | Escherichia coli | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form | Homo sapiens | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form | Rattus norvegicus | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form | Saccharomyces cerevisiae | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | additional information | cellular system of balancing native proteins and oxidatively damaged proteins by use of protein biosynthesis, protein oxidative modification, protein elimination, and oxidized protein repair involving the enzyme, overview, enzyme protects against oxidative damage of proteins | Escherichia coli | ? | - |
? | |
| 1.8.4.12 | additional information | cellular system of balancing native proteins and oxidatively damaged proteins by use of protein biosynthesis, protein oxidative modification, protein elimination, and oxidized protein repair involving the enzyme, overview, enzyme protects against oxidative damage of proteins, enzyme activity is not age-related | Saccharomyces cerevisiae | ? | - |
? | |
| 1.8.4.12 | additional information | cellular system of balancing native proteins and oxidatively damaged proteins by use of protein biosynthesis, protein oxidative modification, protein elimination, and oxidized protein repair involving the enzyme, overview, enzyme protects against oxidative damage of proteins, loss of enzyme activity is age-related | Drosophila melanogaster | ? | - |
? | |
| 1.8.4.12 | additional information | cellular system of balancing native proteins and oxidatively damaged proteins by use of protein biosynthesis, protein oxidative modification, protein elimination, and oxidized protein repair involving the enzyme, overview, enzyme protects against oxidative damage of proteins, loss of enzyme activity is age-related | Homo sapiens | ? | - |
? | |
| 1.8.4.12 | additional information | cellular system of balancing native proteins and oxidatively damaged proteins by use of protein biosynthesis, protein oxidative modification, protein elimination, and oxidized protein repair involving the enzyme, overview, enzyme protects against oxidative damage of proteins, loss of enzyme activity is age-related | Rattus norvegicus | ? | - |
? | |
| 1.8.4.12 | N-acetyl-L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form | Saccharomyces cerevisiae | N-acetyl-L-methionine + thioredoxin disulfide + H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.8.4.11 | MsrA | - |
Drosophila melanogaster |
| 1.8.4.11 | MsrA | - |
Escherichia coli |
| 1.8.4.11 | MsrA | - |
Homo sapiens |
| 1.8.4.11 | MsrA | - |
Rattus norvegicus |
| 1.8.4.11 | MsrA | - |
Saccharomyces cerevisiae |
| 1.8.4.11 | peptide methionine sulfoxide reductase | - |
Drosophila melanogaster |
| 1.8.4.11 | peptide methionine sulfoxide reductase | - |
Escherichia coli |
| 1.8.4.11 | peptide methionine sulfoxide reductase | - |
Homo sapiens |
| 1.8.4.11 | peptide methionine sulfoxide reductase | - |
Rattus norvegicus |
| 1.8.4.11 | peptide methionine sulfoxide reductase | - |
Saccharomyces cerevisiae |
| 1.8.4.12 | MsrB | - |
Drosophila melanogaster |
| 1.8.4.12 | MsrB | - |
Escherichia coli |
| 1.8.4.12 | MsrB | - |
Homo sapiens |
| 1.8.4.12 | MsrB | - |
Rattus norvegicus |
| 1.8.4.12 | MsrB | - |
Saccharomyces cerevisiae |
| 1.8.4.12 | peptide methionine sulfoxide reductase | - |
Drosophila melanogaster |
| 1.8.4.12 | peptide methionine sulfoxide reductase | - |
Escherichia coli |
| 1.8.4.12 | peptide methionine sulfoxide reductase | - |
Homo sapiens |
| 1.8.4.12 | peptide methionine sulfoxide reductase | - |
Rattus norvegicus |
| 1.8.4.12 | peptide methionine sulfoxide reductase | - |
Saccharomyces cerevisiae |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.4.11 | thioredoxin | - |
Drosophila melanogaster | |
| 1.8.4.11 | thioredoxin | - |
Escherichia coli | |
| 1.8.4.11 | thioredoxin | - |
Homo sapiens | |
| 1.8.4.11 | thioredoxin | - |
Rattus norvegicus | |
| 1.8.4.11 | thioredoxin | - |
Saccharomyces cerevisiae | |
| 1.8.4.12 | thioredoxin | - |
Drosophila melanogaster | |
| 1.8.4.12 | thioredoxin | - |
Escherichia coli | |
| 1.8.4.12 | thioredoxin | - |
Homo sapiens | |
| 1.8.4.12 | thioredoxin | - |
Rattus norvegicus | |
| 1.8.4.12 | thioredoxin | - |
Saccharomyces cerevisiae | |
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