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Literature summary extracted from
- Methionine sulfoxide reductases in prokaryotes (2005), Biochim. Biophys. Acta, 1703, 221-229.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.4.11 | additional information | enzyme is induced under oxidative stress and heat shock | Mycobacterium tuberculosis | |
| 1.8.4.11 | additional information | gene msrA is induced during biofilm formation | Escherichia coli | |
| 1.8.4.11 | additional information | the msrA1-msrB operon is induced by antibiotics, expression of msrA1 is increased in the stationary phase but not affected by H2O2 | Staphylococcus aureus | |
| 1.8.4.12 | additional information | enzyme is induced under oxidative stress and heat shock | Mycobacterium tuberculosis | |
| 1.8.4.12 | additional information | the msrA1-msrB operon is induced by antibiotics | Staphylococcus aureus |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.8.4.11 | 3 genes msrA and 1 gene msrB form an operon, one of the 3 msrA genes is fused to the msrB gene, genetic organization and regulation, overview | Staphylococcus aureus |
| 1.8.4.11 | chromosome 1 contains 1 gene msrA, chromosome 2 contains 1 gene msrA | Vibrio cholerae serotype O1 |
| 1.8.4.11 | gene msrA, located in the chromosome at 95.69 min, respectively, recombinant expression of msrA, regulation mechanism of gene expression, overview | Escherichia coli |
| 1.8.4.11 | genes msrA and msrB are translationally fused | Neisseria gonorrhoeae |
| 1.8.4.11 | genes msrA and msrB, EC 1.8.4.12, form an operon | Bacillus subtilis |
| 1.8.4.11 | genes msrA and msrB, methionine S-oxide reductase (R-form oxidizing), are translationally fused | Neisseria meningitidis |
| 1.8.4.11 | the chromosome contains 2 copies of gene msrA, a plasmid harbors 1 copy of gene msrA | Sinorhizobium meliloti |
| 1.8.4.12 | 3 genes msrA and 1 gene msrB form an operon, one of the 3 msrA genes is fused to the msrB gene, genetic organization and regulation, overview | Staphylococcus aureus |
| 1.8.4.12 | chromosome 1 contains 2 genes msrB, chromosome 2 contains 1 gene msrB | Vibrio cholerae serotype O1 |
| 1.8.4.12 | gene msrB, located in the chromosome at 40.09 min, respectively, regulation mechanism of gene expression, overview | Escherichia coli |
| 1.8.4.12 | genes msrA and msrB are translationally fused | Neisseria gonorrhoeae |
| 1.8.4.12 | genes msrA, EC 1.8.4.11, and msrB form an operon | Bacillus subtilis |
| 1.8.4.12 | genes msrB and msrA, EC 1.8.4.11, are translationally fused | Neisseria meningitidis |
| 1.8.4.12 | the chromosome contains 2 copies of gene msrB, a plasmid harbors 1 copy of gene msrB | Sinorhizobium meliloti |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 1.8.4.11 | additional information | a msrA mutant exhibited reduced adherence to erythrocytes as well as increased sensitivity to H2O2 and tert-butyl hydroperoxide killing, the mutant is not able to survive in hamster lungs | Mycoplasma genitalium |
| 1.8.4.11 | additional information | construction of a msrA mutant which shows drastically reduced ability to survive in macrophages compared to the wild-type strain, the mutant shows increased sensitivity to cumene hydroperoxide and tert-butyl hydroperoxide, but not to H2O2, paraquat, or sodium nitrite | Mycolicibacterium smegmatis |
| 1.8.4.11 | additional information | construction of several mutants with reduced virulence via transposon mutagenesis involving mutation of msrA, mutation of msrA leads o increased sensitivity to oxidative agents, non-motility, and reduced spreading-out and life-span of the pathogen in plants | Dickeya chrysanthemi |
| 1.8.4.11 | additional information | mutant strains produce a truncated version of fused MsrA/MsrB with increased sensitivity to H2O2 and superoxide anions | Neisseria gonorrhoeae |
| 1.8.4.11 | additional information | mutation of gene msrA has no effect on virulence, and on resistance to oxidative agents, and causes no defect in cell envelope, msrA is probably linked to biofilm formation | Aggregatibacter actinomycetemcomitans |
| 1.8.4.11 | additional information | mutation of msrA results in reduced development of mature biofilm | Escherichia coli |
| 1.8.4.11 | additional information | mutation of the msr genes impair virulence, overview, mutation of the msrA1 operon leads to increased susceptibility to H2O2 | Staphylococcus aureus |
| 1.8.4.12 | additional information | mutant strains produce a truncated version of fused MsrA/MsrB with increased sensitivity to H2O2 and superoxide anions | Neisseria gonorrhoeae |
| 1.8.4.12 | additional information | mutation of the msr genes impair virulence, overview, mutation of the msrA1 operon leads to increased susceptibility to H2O2 | Staphylococcus aureus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.8.4.11 | extracellular | secretion of MsrA and MsrB, methionine S-oxide reductase (R-form oxidizing), fused together | Helicobacter pylori | - |
- |
| 1.8.4.11 | membrane | outer cell membrane | Neisseria gonorrhoeae | 16020 | - |
| 1.8.4.12 | extracellular | secretion of MsrA, EC 1.8.4.11, and MsrB fused together | Helicobacter pylori | - |
- |
| 1.8.4.12 | membrane | outer cell membrane | Neisseria gonorrhoeae | 16020 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | Staphylococcus aureus | MsrA is specific for the S-form | L-methionine + thioredoxin disulfide + H2O | - |
? |  |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | Mycoplasma genitalium | MsrA is specific for the S-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | Sinorhizobium meliloti | MsrA is specific for the S-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | Bacillus subtilis | MsrA is specific for the S-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | Escherichia coli | MsrA is specific for the S-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | Mycolicibacterium smegmatis | MsrA is specific for the S-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | Neisseria gonorrhoeae | MsrA is specific for the S-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | Neisseria meningitidis | MsrA is specific for the S-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | Mycobacterium tuberculosis | MsrA is specific for the S-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | Helicobacter pylori | MsrA is specific for the S-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | Dickeya chrysanthemi | MsrA is specific for the S-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | Vibrio cholerae serotype O1 | MsrA is specific for the S-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | Aggregatibacter actinomycetemcomitans | MsrA is specific for the S-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.11 | additional information | Neisseria gonorrhoeae | enzyme acts on free and protein-bound methionine | ? | - |
? | |
| 1.8.4.11 | additional information | Mycoplasma genitalium | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide | ? | - |
? | |
| 1.8.4.11 | additional information | Mycobacterium tuberculosis | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, e.g. the heat shock protein and chaperone Hsp16.3, role of the MsrA/MsrB repair pathway in cellular protein dynamics | ? | - |
? | |
| 1.8.4.11 | additional information | Sinorhizobium meliloti | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, role of the MsrA/MsrB repair pathway in cellular protein dynamics | ? | - |
? | |
| 1.8.4.11 | additional information | Bacillus subtilis | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, role of the MsrA/MsrB repair pathway in cellular protein dynamics | ? | - |
? | |
| 1.8.4.11 | additional information | Mycolicibacterium smegmatis | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, role of the MsrA/MsrB repair pathway in cellular protein dynamics | ? | - |
? | |
| 1.8.4.11 | additional information | Helicobacter pylori | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, role of the MsrA/MsrB repair pathway in cellular protein dynamics | ? | - |
? | |
| 1.8.4.11 | additional information | Dickeya chrysanthemi | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, role of the MsrA/MsrB repair pathway in cellular protein dynamics | ? | - |
? | |
| 1.8.4.11 | additional information | Vibrio cholerae serotype O1 | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, role of the MsrA/MsrB repair pathway in cellular protein dynamics | ? | - |
? | |
| 1.8.4.11 | additional information | Staphylococcus aureus | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, role of the MsrA/MsrB repair pathway in cellular protein dynamics, MsrA is important for virulence in mice | ? | - |
? | |
| 1.8.4.11 | additional information | Escherichia coli | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, role of the MsrA/MsrB repair pathway in cellular protein dynamics, the MsrA/MsrB repair pathway is involved in the signal recognition particle-dependent protein targeting pathway, regulation mechanism of gene expression, overview | ? | - |
? | |
| 1.8.4.11 | additional information | Neisseria meningitidis | enzymes acts on free and protein-bound methionine | ? | - |
? | |
| 1.8.4.11 | additional information | Aggregatibacter actinomycetemcomitans | role of the MsrA/MsrB repair pathway in cellular protein dynamics, mutation of gene msrA has no effect on virulence, and on resistance to oxidative agents, and causes no defect in cell envelope, msrA is probably linked to biofilm formation, enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide | ? | - |
? | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin | Staphylococcus aureus | MsrB is specific for the R-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin | Sinorhizobium meliloti | MsrB is specific for the R-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin | Bacillus subtilis | MsrB is specific for the R-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin | Escherichia coli | MsrB is specific for the R-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin | Mycolicibacterium smegmatis | MsrB is specific for the R-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin | Neisseria gonorrhoeae | MsrB is specific for the R-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin | Neisseria meningitidis | MsrB is specific for the R-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin | Mycobacterium tuberculosis | MsrB is specific for the R-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin | Helicobacter pylori | MsrB is specific for the R-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin | Dickeya chrysanthemi | MsrB is specific for the R-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin | Vibrio cholerae serotype O1 | MsrB is specific for the R-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin | Aggregatibacter actinomycetemcomitans | MsrB is specific for the R-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | additional information | Neisseria gonorrhoeae | enzyme acts on free and protein-bound methionine | ? | - |
? | |
| 1.8.4.12 | additional information | Neisseria meningitidis | enzyme acts on free and protein-bound methionine | ? | - |
? | |
| 1.8.4.12 | additional information | Mycobacterium tuberculosis | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, e.g. the heat shock protein and chaperone Hsp16.3, role of the MsrA/MsrB repair pathway in cellular protein dynamics | ? | - |
? | |
| 1.8.4.12 | additional information | Staphylococcus aureus | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, role of the MsrA/MsrB repair pathway in cellular protein dynamics | ? | - |
? | |
| 1.8.4.12 | additional information | Sinorhizobium meliloti | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, role of the MsrA/MsrB repair pathway in cellular protein dynamics | ? | - |
? | |
| 1.8.4.12 | additional information | Bacillus subtilis | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, role of the MsrA/MsrB repair pathway in cellular protein dynamics | ? | - |
? | |
| 1.8.4.12 | additional information | Mycolicibacterium smegmatis | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, role of the MsrA/MsrB repair pathway in cellular protein dynamics | ? | - |
? | |
| 1.8.4.12 | additional information | Helicobacter pylori | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, role of the MsrA/MsrB repair pathway in cellular protein dynamics | ? | - |
? | |
| 1.8.4.12 | additional information | Dickeya chrysanthemi | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, role of the MsrA/MsrB repair pathway in cellular protein dynamics | ? | - |
? | |
| 1.8.4.12 | additional information | Vibrio cholerae serotype O1 | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, role of the MsrA/MsrB repair pathway in cellular protein dynamics | ? | - |
? | |
| 1.8.4.12 | additional information | Escherichia coli | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, role of the MsrA/MsrB repair pathway in cellular protein dynamics, the MsrA/MsrB repair pathway is involved in the signal recognition particle-dependent protein targeting pathway, regulation mechanism of gene expression, overview | ? | - |
? | |
| 1.8.4.12 | additional information | Aggregatibacter actinomycetemcomitans | role of the MsrA/MsrB repair pathway in cellular protein dynamics, enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.4.11 | Aggregatibacter actinomycetemcomitans | - |
- |
- |
| 1.8.4.11 | Bacillus subtilis | - |
- |
- |
| 1.8.4.11 | Dickeya chrysanthemi | - |
- |
- |
| 1.8.4.11 | Escherichia coli | - |
1 copy gene msrA | - |
| 1.8.4.11 | Helicobacter pylori | - |
- |
- |
| 1.8.4.11 | Mycobacterium tuberculosis | - |
- |
- |
| 1.8.4.11 | Mycolicibacterium smegmatis | - |
- |
- |
| 1.8.4.11 | Mycoplasma genitalium | - |
- |
- |
| 1.8.4.11 | Neisseria gonorrhoeae | - |
- |
- |
| 1.8.4.11 | Neisseria meningitidis | - |
- |
- |
| 1.8.4.11 | no activity in Aquifex aeolicus | - |
- |
- |
| 1.8.4.11 | no activity in Thermotoga maritima | - |
- |
- |
| 1.8.4.11 | Sinorhizobium meliloti | - |
3 copies of gene msrA | - |
| 1.8.4.11 | Staphylococcus aureus | - |
3 copies of gene msrA, encoding MsrA1, MsrA2,and MsrA3 | - |
| 1.8.4.11 | Vibrio cholerae serotype O1 | - |
2 isozymes of MsrA | - |
| 1.8.4.12 | Aggregatibacter actinomycetemcomitans | - |
- |
- |
| 1.8.4.12 | Bacillus subtilis | - |
- |
- |
| 1.8.4.12 | Dickeya chrysanthemi | - |
- |
- |
| 1.8.4.12 | Escherichia coli | - |
1 copy gene msrB | - |
| 1.8.4.12 | Helicobacter pylori | - |
- |
- |
| 1.8.4.12 | Mycobacterium tuberculosis | - |
- |
- |
| 1.8.4.12 | Mycolicibacterium smegmatis | - |
- |
- |
| 1.8.4.12 | Neisseria gonorrhoeae | - |
- |
- |
| 1.8.4.12 | Neisseria meningitidis | - |
- |
- |
| 1.8.4.12 | no activity in Aquifex aeolicus | - |
- |
- |
| 1.8.4.12 | no activity in Thermotoga maritima | - |
- |
- |
| 1.8.4.12 | Sinorhizobium meliloti | - |
3 copies of gene msrB | - |
| 1.8.4.12 | Staphylococcus aureus | - |
1 copy of gene msrB | - |
| 1.8.4.12 | Vibrio cholerae serotype O1 | - |
3 isozymes of MsrB | - |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O | catalytic mechanism involves the formation of a sulfenic acid intermediate | Staphylococcus aureus | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O | catalytic mechanism involves the formation of a sulfenic acid intermediate | Mycoplasma genitalium | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O | catalytic mechanism involves the formation of a sulfenic acid intermediate | Sinorhizobium meliloti | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O | catalytic mechanism involves the formation of a sulfenic acid intermediate | Bacillus subtilis | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O | catalytic mechanism involves the formation of a sulfenic acid intermediate | Escherichia coli | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O | catalytic mechanism involves the formation of a sulfenic acid intermediate | Mycolicibacterium smegmatis | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O | catalytic mechanism involves the formation of a sulfenic acid intermediate | Neisseria gonorrhoeae | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O | catalytic mechanism involves the formation of a sulfenic acid intermediate | Neisseria meningitidis | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O | catalytic mechanism involves the formation of a sulfenic acid intermediate | Mycobacterium tuberculosis | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O | catalytic mechanism involves the formation of a sulfenic acid intermediate | Helicobacter pylori | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O | catalytic mechanism involves the formation of a sulfenic acid intermediate | Dickeya chrysanthemi | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O | catalytic mechanism involves the formation of a sulfenic acid intermediate | Vibrio cholerae serotype O1 | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O | catalytic mechanism involves the formation of a sulfenic acid intermediate | Aggregatibacter actinomycetemcomitans | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O | catalytic mechanism involves the formation of a sulfenic acid intermediate | Staphylococcus aureus | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O | catalytic mechanism involves the formation of a sulfenic acid intermediate | Sinorhizobium meliloti | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O | catalytic mechanism involves the formation of a sulfenic acid intermediate | Bacillus subtilis | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O | catalytic mechanism involves the formation of a sulfenic acid intermediate | Escherichia coli | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O | catalytic mechanism involves the formation of a sulfenic acid intermediate | Mycolicibacterium smegmatis | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O | catalytic mechanism involves the formation of a sulfenic acid intermediate | Neisseria gonorrhoeae | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O | catalytic mechanism involves the formation of a sulfenic acid intermediate | Neisseria meningitidis | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O | catalytic mechanism involves the formation of a sulfenic acid intermediate | Mycobacterium tuberculosis | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O | catalytic mechanism involves the formation of a sulfenic acid intermediate | Helicobacter pylori | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O | catalytic mechanism involves the formation of a sulfenic acid intermediate | Dickeya chrysanthemi | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O | catalytic mechanism involves the formation of a sulfenic acid intermediate | Vibrio cholerae serotype O1 | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin = L-methionine + thioredoxin disulfide + H2O | catalytic mechanism involves the formation of a sulfenic acid intermediate | Aggregatibacter actinomycetemcomitans |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | MsrA is specific for the S-form | Staphylococcus aureus | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | MsrA is specific for the S-form | Mycoplasma genitalium | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | MsrA is specific for the S-form | Sinorhizobium meliloti | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | MsrA is specific for the S-form | Bacillus subtilis | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | MsrA is specific for the S-form | Escherichia coli | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | MsrA is specific for the S-form | Mycolicibacterium smegmatis | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | MsrA is specific for the S-form | Neisseria gonorrhoeae | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | MsrA is specific for the S-form | Neisseria meningitidis | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | MsrA is specific for the S-form | Mycobacterium tuberculosis | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | MsrA is specific for the S-form | Helicobacter pylori | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | MsrA is specific for the S-form | Dickeya chrysanthemi | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | MsrA is specific for the S-form | Vibrio cholerae serotype O1 | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.11 | L-methionine (S)-sulfoxide + thioredoxin | MsrA is specific for the S-form | Aggregatibacter actinomycetemcomitans | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.11 | additional information | enzyme acts on free and protein-bound methionine | Staphylococcus aureus | ? | - |
? | |
| 1.8.4.11 | additional information | enzyme acts on free and protein-bound methionine | Mycoplasma genitalium | ? | - |
? | |
| 1.8.4.11 | additional information | enzyme acts on free and protein-bound methionine | Sinorhizobium meliloti | ? | - |
? | |
| 1.8.4.11 | additional information | enzyme acts on free and protein-bound methionine | Bacillus subtilis | ? | - |
? | |
| 1.8.4.11 | additional information | enzyme acts on free and protein-bound methionine | Escherichia coli | ? | - |
? | |
| 1.8.4.11 | additional information | enzyme acts on free and protein-bound methionine | Mycolicibacterium smegmatis | ? | - |
? | |
| 1.8.4.11 | additional information | enzyme acts on free and protein-bound methionine | Neisseria gonorrhoeae | ? | - |
? | |
| 1.8.4.11 | additional information | enzyme acts on free and protein-bound methionine | Neisseria meningitidis | ? | - |
? | |
| 1.8.4.11 | additional information | enzyme acts on free and protein-bound methionine | Mycobacterium tuberculosis | ? | - |
? | |
| 1.8.4.11 | additional information | enzyme acts on free and protein-bound methionine | Helicobacter pylori | ? | - |
? | |
| 1.8.4.11 | additional information | enzyme acts on free and protein-bound methionine | Dickeya chrysanthemi | ? | - |
? | |
| 1.8.4.11 | additional information | enzyme acts on free and protein-bound methionine | Vibrio cholerae serotype O1 | ? | - |
? | |
| 1.8.4.11 | additional information | enzyme acts on free and protein-bound methionine | Aggregatibacter actinomycetemcomitans | ? | - |
? | |
| 1.8.4.11 | additional information | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide | Mycoplasma genitalium | ? | - |
? | |
| 1.8.4.11 | additional information | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, e.g. the heat shock protein and chaperone Hsp16.3, role of the MsrA/MsrB repair pathway in cellular protein dynamics | Mycobacterium tuberculosis | ? | - |
? | |
| 1.8.4.11 | additional information | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, role of the MsrA/MsrB repair pathway in cellular protein dynamics | Sinorhizobium meliloti | ? | - |
? | |
| 1.8.4.11 | additional information | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, role of the MsrA/MsrB repair pathway in cellular protein dynamics | Bacillus subtilis | ? | - |
? | |
| 1.8.4.11 | additional information | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, role of the MsrA/MsrB repair pathway in cellular protein dynamics | Mycolicibacterium smegmatis | ? | - |
? | |
| 1.8.4.11 | additional information | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, role of the MsrA/MsrB repair pathway in cellular protein dynamics | Helicobacter pylori | ? | - |
? | |
| 1.8.4.11 | additional information | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, role of the MsrA/MsrB repair pathway in cellular protein dynamics | Dickeya chrysanthemi | ? | - |
? | |
| 1.8.4.11 | additional information | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, role of the MsrA/MsrB repair pathway in cellular protein dynamics | Vibrio cholerae serotype O1 | ? | - |
? | |
| 1.8.4.11 | additional information | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, role of the MsrA/MsrB repair pathway in cellular protein dynamics, MsrA is important for virulence in mice | Staphylococcus aureus | ? | - |
? | |
| 1.8.4.11 | additional information | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, role of the MsrA/MsrB repair pathway in cellular protein dynamics, the MsrA/MsrB repair pathway is involved in the signal recognition particle-dependent protein targeting pathway, regulation mechanism of gene expression, overview | Escherichia coli | ? | - |
? | |
| 1.8.4.11 | additional information | enzymes acts on free and protein-bound methionine | Neisseria meningitidis | ? | - |
? | |
| 1.8.4.11 | additional information | role of the MsrA/MsrB repair pathway in cellular protein dynamics, mutation of gene msrA has no effect on virulence, and on resistance to oxidative agents, and causes no defect in cell envelope, msrA is probably linked to biofilm formation, enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide | Aggregatibacter actinomycetemcomitans | ? | - |
? | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form | Staphylococcus aureus | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form | Sinorhizobium meliloti | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form | Bacillus subtilis | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form | Escherichia coli | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form | Mycolicibacterium smegmatis | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form | Neisseria gonorrhoeae | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form | Neisseria meningitidis | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form | Mycobacterium tuberculosis | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form | Helicobacter pylori | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form | Dickeya chrysanthemi | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form | Vibrio cholerae serotype O1 | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form | Aggregatibacter actinomycetemcomitans | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| 1.8.4.12 | additional information | enzyme acts on free and protein-bound methionine | Staphylococcus aureus | ? | - |
? | |
| 1.8.4.12 | additional information | enzyme acts on free and protein-bound methionine | Sinorhizobium meliloti | ? | - |
? | |
| 1.8.4.12 | additional information | enzyme acts on free and protein-bound methionine | Bacillus subtilis | ? | - |
? | |
| 1.8.4.12 | additional information | enzyme acts on free and protein-bound methionine | Escherichia coli | ? | - |
? | |
| 1.8.4.12 | additional information | enzyme acts on free and protein-bound methionine | Mycolicibacterium smegmatis | ? | - |
? | |
| 1.8.4.12 | additional information | enzyme acts on free and protein-bound methionine | Neisseria gonorrhoeae | ? | - |
? | |
| 1.8.4.12 | additional information | enzyme acts on free and protein-bound methionine | Neisseria meningitidis | ? | - |
? | |
| 1.8.4.12 | additional information | enzyme acts on free and protein-bound methionine | Mycobacterium tuberculosis | ? | - |
? | |
| 1.8.4.12 | additional information | enzyme acts on free and protein-bound methionine | Helicobacter pylori | ? | - |
? | |
| 1.8.4.12 | additional information | enzyme acts on free and protein-bound methionine | Dickeya chrysanthemi | ? | - |
? | |
| 1.8.4.12 | additional information | enzyme acts on free and protein-bound methionine | Vibrio cholerae serotype O1 | ? | - |
? | |
| 1.8.4.12 | additional information | enzyme acts on free and protein-bound methionine | Aggregatibacter actinomycetemcomitans | ? | - |
? | |
| 1.8.4.12 | additional information | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, e.g. the heat shock protein and chaperone Hsp16.3, role of the MsrA/MsrB repair pathway in cellular protein dynamics | Mycobacterium tuberculosis | ? | - |
? | |
| 1.8.4.12 | additional information | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, role of the MsrA/MsrB repair pathway in cellular protein dynamics | Staphylococcus aureus | ? | - |
? | |
| 1.8.4.12 | additional information | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, role of the MsrA/MsrB repair pathway in cellular protein dynamics | Sinorhizobium meliloti | ? | - |
? | |
| 1.8.4.12 | additional information | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, role of the MsrA/MsrB repair pathway in cellular protein dynamics | Bacillus subtilis | ? | - |
? | |
| 1.8.4.12 | additional information | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, role of the MsrA/MsrB repair pathway in cellular protein dynamics | Mycolicibacterium smegmatis | ? | - |
? | |
| 1.8.4.12 | additional information | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, role of the MsrA/MsrB repair pathway in cellular protein dynamics | Helicobacter pylori | ? | - |
? | |
| 1.8.4.12 | additional information | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, role of the MsrA/MsrB repair pathway in cellular protein dynamics | Dickeya chrysanthemi | ? | - |
? | |
| 1.8.4.12 | additional information | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, role of the MsrA/MsrB repair pathway in cellular protein dynamics | Vibrio cholerae serotype O1 | ? | - |
? | |
| 1.8.4.12 | additional information | enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide, role of the MsrA/MsrB repair pathway in cellular protein dynamics, the MsrA/MsrB repair pathway is involved in the signal recognition particle-dependent protein targeting pathway, regulation mechanism of gene expression, overview | Escherichia coli | ? | - |
? | |
| 1.8.4.12 | additional information | role of the MsrA/MsrB repair pathway in cellular protein dynamics, enzyme repairs oxidatively damaged free and protein bound methionine and recycles it from methionine sulfoxide | Aggregatibacter actinomycetemcomitans | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.8.4.11 | More | MsrA and enzyme MsrB, methionine S-oxide reductase (R-form oxidizing), form domains of a single polypeptide together with a third thioredoxin-like domain | Neisseria meningitidis |
| 1.8.4.11 | More | MsrA and MsrB, EC 1.8.4.12, are fused together | Helicobacter pylori |
| 1.8.4.11 | More | the 2 enzyme activities, MsrA and MsrB, form domains of a single polypeptide together with a third thioredoxin-like domain | Neisseria gonorrhoeae |
| 1.8.4.12 | More | MsrA, EC 1.8.4.11, and MsrB are fused together | Helicobacter pylori |
| 1.8.4.12 | More | MsrB and enzyme MsrA, EC 1.8.4.11, form domains of a single polypeptide together with a third thioredoxin-like domain | Neisseria meningitidis |
| 1.8.4.12 | More | the 2 enzyme activities, MsrA and MsrB, form domains of a single polypeptide together with a third thioredoxin-like domain | Neisseria gonorrhoeae |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.8.4.11 | methionine sulfoxide reductase | - |
Staphylococcus aureus |
| 1.8.4.11 | methionine sulfoxide reductase | - |
Mycoplasma genitalium |
| 1.8.4.11 | methionine sulfoxide reductase | - |
Sinorhizobium meliloti |
| 1.8.4.11 | methionine sulfoxide reductase | - |
Bacillus subtilis |
| 1.8.4.11 | methionine sulfoxide reductase | - |
Escherichia coli |
| 1.8.4.11 | methionine sulfoxide reductase | - |
Mycolicibacterium smegmatis |
| 1.8.4.11 | methionine sulfoxide reductase | - |
Neisseria gonorrhoeae |
| 1.8.4.11 | methionine sulfoxide reductase | - |
Neisseria meningitidis |
| 1.8.4.11 | methionine sulfoxide reductase | - |
Mycobacterium tuberculosis |
| 1.8.4.11 | methionine sulfoxide reductase | - |
Helicobacter pylori |
| 1.8.4.11 | methionine sulfoxide reductase | - |
Dickeya chrysanthemi |
| 1.8.4.11 | methionine sulfoxide reductase | - |
Vibrio cholerae serotype O1 |
| 1.8.4.11 | methionine sulfoxide reductase | - |
Aggregatibacter actinomycetemcomitans |
| 1.8.4.11 | MsrA | - |
Staphylococcus aureus |
| 1.8.4.11 | MsrA | - |
Mycoplasma genitalium |
| 1.8.4.11 | MsrA | - |
Sinorhizobium meliloti |
| 1.8.4.11 | MsrA | - |
Bacillus subtilis |
| 1.8.4.11 | MsrA | - |
Escherichia coli |
| 1.8.4.11 | MsrA | - |
Mycolicibacterium smegmatis |
| 1.8.4.11 | MsrA | - |
Neisseria gonorrhoeae |
| 1.8.4.11 | MsrA | - |
Neisseria meningitidis |
| 1.8.4.11 | MsrA | - |
Mycobacterium tuberculosis |
| 1.8.4.11 | MsrA | - |
Helicobacter pylori |
| 1.8.4.11 | MsrA | - |
Dickeya chrysanthemi |
| 1.8.4.11 | MsrA | - |
Vibrio cholerae serotype O1 |
| 1.8.4.11 | MsrA | - |
Aggregatibacter actinomycetemcomitans |
| 1.8.4.12 | methionine sulfoxide reductase | - |
Staphylococcus aureus |
| 1.8.4.12 | methionine sulfoxide reductase | - |
Sinorhizobium meliloti |
| 1.8.4.12 | methionine sulfoxide reductase | - |
Bacillus subtilis |
| 1.8.4.12 | methionine sulfoxide reductase | - |
Escherichia coli |
| 1.8.4.12 | methionine sulfoxide reductase | - |
Mycolicibacterium smegmatis |
| 1.8.4.12 | methionine sulfoxide reductase | - |
Neisseria gonorrhoeae |
| 1.8.4.12 | methionine sulfoxide reductase | - |
Neisseria meningitidis |
| 1.8.4.12 | methionine sulfoxide reductase | - |
Mycobacterium tuberculosis |
| 1.8.4.12 | methionine sulfoxide reductase | - |
Helicobacter pylori |
| 1.8.4.12 | methionine sulfoxide reductase | - |
Dickeya chrysanthemi |
| 1.8.4.12 | methionine sulfoxide reductase | - |
Vibrio cholerae serotype O1 |
| 1.8.4.12 | methionine sulfoxide reductase | - |
Aggregatibacter actinomycetemcomitans |
| 1.8.4.12 | MsrB | - |
Staphylococcus aureus |
| 1.8.4.12 | MsrB | - |
Sinorhizobium meliloti |
| 1.8.4.12 | MsrB | - |
Bacillus subtilis |
| 1.8.4.12 | MsrB | - |
Escherichia coli |
| 1.8.4.12 | MsrB | - |
Mycolicibacterium smegmatis |
| 1.8.4.12 | MsrB | - |
Neisseria gonorrhoeae |
| 1.8.4.12 | MsrB | - |
Neisseria meningitidis |
| 1.8.4.12 | MsrB | - |
Mycobacterium tuberculosis |
| 1.8.4.12 | MsrB | - |
Helicobacter pylori |
| 1.8.4.12 | MsrB | - |
Dickeya chrysanthemi |
| 1.8.4.12 | MsrB | - |
Vibrio cholerae serotype O1 |
| 1.8.4.12 | MsrB | - |
Aggregatibacter actinomycetemcomitans |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.4.11 | thioredoxin | - |
Staphylococcus aureus | |
| 1.8.4.11 | thioredoxin | - |
Mycoplasma genitalium | |
| 1.8.4.11 | thioredoxin | - |
Sinorhizobium meliloti | |
| 1.8.4.11 | thioredoxin | - |
Bacillus subtilis | |
| 1.8.4.11 | thioredoxin | - |
Escherichia coli | |
| 1.8.4.11 | thioredoxin | - |
Mycolicibacterium smegmatis | |
| 1.8.4.11 | thioredoxin | - |
Neisseria gonorrhoeae | |
| 1.8.4.11 | thioredoxin | - |
Neisseria meningitidis | |
| 1.8.4.11 | thioredoxin | - |
Mycobacterium tuberculosis | |
| 1.8.4.11 | thioredoxin | - |
Helicobacter pylori | |
| 1.8.4.11 | thioredoxin | - |
Dickeya chrysanthemi | |
| 1.8.4.11 | thioredoxin | - |
Vibrio cholerae serotype O1 | |
| 1.8.4.11 | thioredoxin | - |
Aggregatibacter actinomycetemcomitans | |
| 1.8.4.12 | thioredoxin | - |
Staphylococcus aureus | |
| 1.8.4.12 | thioredoxin | - |
Sinorhizobium meliloti | |
| 1.8.4.12 | thioredoxin | - |
Bacillus subtilis | |
| 1.8.4.12 | thioredoxin | - |
Escherichia coli | |
| 1.8.4.12 | thioredoxin | - |
Mycolicibacterium smegmatis | |
| 1.8.4.12 | thioredoxin | - |
Neisseria gonorrhoeae | |
| 1.8.4.12 | thioredoxin | - |
Neisseria meningitidis | |
| 1.8.4.12 | thioredoxin | - |
Mycobacterium tuberculosis | |
| 1.8.4.12 | thioredoxin | - |
Helicobacter pylori | |
| 1.8.4.12 | thioredoxin | - |
Dickeya chrysanthemi | |
| 1.8.4.12 | thioredoxin | - |
Vibrio cholerae serotype O1 | |
| 1.8.4.12 | thioredoxin | - |
Aggregatibacter actinomycetemcomitans | |
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Release 2023.1 (January 2023)
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