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Literature summary extracted from

  • Zhang, X.; Fujii, H.; Matera, K.M.; Migita, C.T.; Sun, D.; Sato, M.; Ikeda-Saito, M.; Yoshida, T.
    Stereoselectivity of each of the three steps of the heme oxygenase reaction: Hemin to meso-hydroxyhemin, meso-hydroxyhemin to verdoheme, and verdoheme to biliverdin (2003), Biochemistry, 42, 7418-7426.
    View publication on PubMed

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.18 Rattus norvegicus
-
 truncated, soluble form
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.18 alpha-meso-hydroxyhemin IX + reduced acceptor + O2
-
 Rattus norvegicus verdoheme IXalpha + CO + acceptor + H2O
-
 ?
1.14.14.18 beta-meso-hydroxyhemin IX + reduced acceptor + O2
-
 Rattus norvegicus verdoheme IXbeta + CO + acceptor + H2O
-
 ?
1.14.14.18 delta-meso-hydroxyhemin IX + reduced acceptor + O2
-
 Rattus norvegicus verdoheme IXdelta + CO + acceptor + H2O
-
 ?
1.14.14.18 gamma-meso-hydroxyhemin IX + reduced acceptor + O2
-
 Rattus norvegicus verdoheme IXgamma + CO + acceptor + H2O
-
 ?
1.14.14.18 hemin + reduced acceptor + O2
-
 Rattus norvegicus alpha-meso-hydroxyhemin IX + CO + acceptor + H2O
-
 ?
1.14.14.18 additional information reaction proceeds via three steps, first step is alpha-regioselective hydroxylation of hemin, second degradation of meso-hydroxyhemin to verdoheme and third degradation of verdoheme to biliverdin, which again is stereoselective for verdoheme IXalpha. In the second step, enzyme would convert all four isomers of meso-hydroxyhemin Rattus norvegicus ?
-
 ?
1.14.14.18 verdoheme IXalpha + H2O
-
 Rattus norvegicus biliverdin IXalpha + Fe2+
-
 ?