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Literature summary extracted from

  • Li, H.; Samouilov, A.; Liu, X.; Zweier, J.L.
    Characterization of the magnitude and kinetics of xanthine oxidase-catalyzed nitrate reduction: evaluation of its role in nitrite and nitric oxide generation in anoxic tissues (2003), Biochemistry, 42, 1150-1159.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.17.3.2 diphenylene iodonium chloride inhibits nitrate reduction only when NADH is used as reducing substrate and does not inhibit nitrite generation when xanthine is used Bos taurus
1.17.3.2 oxypurinol
-
 Bos taurus
1.17.3.2 xanthine at high concentrations Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.17.3.2 0.0253
-
 2,3-Dihydroxybenzaldehyde in presence of 1.0 mM nitrate Bos taurus
1.17.3.2 0.86
-
 NADH in presence of 1.0 mM nitrate Bos taurus
1.17.3.2 6.6
-
 xanthine in presence of 2 mM NADH Bos taurus
1.17.3.2 6.8
-
 xanthine in presence of 0.5 mM 2,3-dihydroxybenzaldehyde Bos taurus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.17.3.2 Molybdenum nitrate reduction to nitrite as well as nitrite reduction to NO occurs at the molybdenum site Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.17.3.2 nitrate + NADH Bos taurus reaction can be an important source of NO production in ischemic tissues nitrite + NAD+ + H2O
-
 ?
1.17.3.2 nitrite + NADH Bos taurus reaction can be an important source of NO production in ischemic tissues NO + NAD+ + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.17.3.2 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.17.3.2 milk
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.17.3.2 nitrate + 2,3-dihydroxybenzaldehyde
-
 Bos taurus nitrite + ?
-
 ?
1.17.3.2 nitrate + NADH
-
 Bos taurus nitrite + NAD+ + H2O
-
 ?
1.17.3.2 nitrate + NADH reaction can be an important source of NO production in ischemic tissues Bos taurus nitrite + NAD+ + H2O
-
 ?
1.17.3.2 nitrate + xanthine
-
 Bos taurus nitrite + urate + ?
-
 ?
1.17.3.2 nitrite + NADH
-
 Bos taurus NO + NAD+ + H2O
-
 ?
1.17.3.2 nitrite + NADH reaction can be an important source of NO production in ischemic tissues Bos taurus NO + NAD+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.17.3.2 XO
-
 Bos taurus
1.17.3.2 XOR
-
 Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.17.3.2 5
-
 generation of nitrite or NO Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
1.17.3.2 NADH
-
 Bos taurus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.17.3.2 0.08
-
 xanthine
-
 Bos taurus